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Beyond classical benzodiazepines: novel therapeutic potential of GABA A receptor subtypes

Nature reviews. Drug discovery, 2011-09, Vol.10 (9), p.685-697

2011

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Selective degeneration of septal and hippocampal GABAergic neurons in a mouse model of amyloidosis and tauopathy

Neurobiology of disease, 2012-07, Vol.47 (1), p.1-12

2012

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Reducing GABAA α5 receptor-mediated inhibition rescues functional and neuromorphological deficits in a mouse model of down syndrome

The Journal of neuroscience, 2013-02, Vol.33 (9), p.3953-3966

2013

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Parvalbumin expression and gamma oscillation occurrence increase over time in a neurodevelopmental model of NMDA receptor dysfunction

PeerJ (San Francisco, CA), 2018-09, Vol.6, p.e5543-e5543, Article e5543

2018

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RO4938581, a novel cognitive enhancer acting at GABAA α5 subunit-containing receptors

Psychopharmacology, 2009-01, Vol.202 (1-3), p.207-223

2009

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Pharmacological modulation of GABAA receptors

Current opinion in pharmacology, 2021-08, Vol.59, p.3-10

2021

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Beyond classical benzodiazepines: novel therapeutic potential of GABAA receptor subtypes

Nature reviews. Drug discovery, 2011-07, Vol.10 (9), p.685-697

2011

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Fluorinated 9H-xanthene-9-carboxylic acid oxazol-2-yl-amides as potent, orally available mGlu1 receptor enhancers

Bioorganic & medicinal chemistry letters, 2009-03, Vol.19 (6), p.1666-1669

2009

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Effect of bitopertin, a glycine reuptake inhibitor, on negative symptoms of schizophrenia: a randomized, double-blind, proof-of-concept study

JAMA psychiatry (Chicago, Ill.), 2014-06, Vol.71 (6), p.637

2014

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Positive Allosteric Modulators of Metabotropic Glutamate 1 Receptor: Characterization, Mechanism of Action, and Binding Site

Proceedings of the National Academy of Sciences - PNAS, 2001-11, Vol.98 (23), p.13402-13407

2001

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Dendrite-targeting interneurons control synaptic NMDA-receptor activation via nonlinear α5-GABAA receptors

Nature communications, 2018-09, Vol.9 (1), p.1-16, Article 3576

2018

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Enhanced dentate gyrus synaptic plasticity but reduced neurogenesis in a mouse model of amyloidosis

Neurobiology of disease, 2010-11, Vol.40 (2), p.386-393

2010

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The discovery and unique pharmacological profile of RO4938581 and RO4882224 as potent and selective GABAA α5 inverse agonists for the treatment of cognitive dysfunction

Bioorganic & medicinal chemistry letters, 2009-10, Vol.19 (20), p.5940-5944

2009

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Identification of a Corticohabenular Circuit Regulating Socially Directed Behavior

Biological psychiatry (1969), 2018-04, Vol.83 (7), p.607-617

2018

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mTORC1 Inhibition Corrects Neurodevelopmental and Synaptic Alterations in a Human Stem Cell Model of Tuberous Sclerosis

Cell reports (Cambridge), 2016-04, Vol.15 (1), p.86-95

2016

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Mutational Analysis and Molecular Modeling of the Allosteric Binding Site of a Novel, Selective, Noncompetitive Antagonist of the Metabotropic Glutamate 1 Receptor

The Journal of biological chemistry, 2003-03, Vol.278 (10), p.8340-8347

2003

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Gantenerumab: a novel human anti-Aβ antibody demonstrates sustained cerebral amyloid-β binding and elicits cell-mediated removal of human amyloid-β

Journal of Alzheimer's disease, 2012-01, Vol.28 (1), p.49-69

2012

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Basmisanil, a highly selective GABAA-α5 negative allosteric modulator: preclinical pharmacology and demonstration of functional target engagement in man

Scientific reports, 2021-04, Vol.11 (1), p.7700-7700, Article 7700

2021

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Cognitive impairment in major depression and the mGlu2 receptor as a therapeutic target

Neuropharmacology, 2013-01, Vol.64, p.337-346

2013

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Methods for the Discovery of Novel Compounds Modulating a Gamma-Aminobutyric Acid Receptor Type A Neurotransmission

Journal of visualized experiments, 2018-08 (138)

2018

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Glycine reuptake inhibitor RG1678: A pharmacologic characterization of an investigational agent for the treatment of schizophrenia

Neuropharmacology, 2012-02, Vol.62 (2), p.1152-1161

2012

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GABAA receptor-mediated neurotransmission: Not so simple after all

Biochemical pharmacology, 2016-09, Vol.115, p.10-17

2016

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Selective oxytocin receptor activation prevents prefrontal circuit dysfunction and social behavioral alterations in response to chronic prefrontal cortex activation in male rats

Frontiers in cellular neuroscience, 2023-12, Vol.17, p.1286552-1286552

2023

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Discovery of the imidazo[1,5-α][1,2,4].triazolo[1,5-d][1,4]benzodiazepine scaffold as a novel, potent and selective GABAA α5 inverse agonist series

Bioorganic & medicinal chemistry letters, 2009-10, Vol.19 (19), p.5746-5752

2009

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Identification of Essential Residues Involved in the Glutamate Binding Pocket of the Group II Metabotropic Glutamate Receptor

Molecular pharmacology, 2001-11, Vol.60 (5), p.944-954

2001

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Beyond classical benzodiazepines: novel therapeutic potential of GABA A receptor subtypes

Selective degeneration of septal and hippocampal GABAergic neurons in a mouse model of amyloidosis and tauopathy

Reducing GABAA α5 receptor-mediated inhibition rescues functional and neuromorphological deficits in a mouse model of down syndrome

Parvalbumin expression and gamma oscillation occurrence increase over time in a neurodevelopmental model of NMDA receptor dysfunction

RO4938581, a novel cognitive enhancer acting at GABAA α5 subunit-containing receptors

Pharmacological modulation of GABAA receptors

Beyond classical benzodiazepines: novel therapeutic potential of GABAA receptor subtypes

Fluorinated 9H-xanthene-9-carboxylic acid oxazol-2-yl-amides as potent, orally available mGlu1 receptor enhancers

Effect of bitopertin, a glycine reuptake inhibitor, on negative symptoms of schizophrenia: a randomized, double-blind, proof-of-concept study

Positive Allosteric Modulators of Metabotropic Glutamate 1 Receptor: Characterization, Mechanism of Action, and Binding Site

Dendrite-targeting interneurons control synaptic NMDA-receptor activation via nonlinear α5-GABAA receptors

Enhanced dentate gyrus synaptic plasticity but reduced neurogenesis in a mouse model of amyloidosis

The discovery and unique pharmacological profile of RO4938581 and RO4882224 as potent and selective GABAA α5 inverse agonists for the treatment of cognitive dysfunction

Identification of a Corticohabenular Circuit Regulating Socially Directed Behavior

mTORC1 Inhibition Corrects Neurodevelopmental and Synaptic Alterations in a Human Stem Cell Model of Tuberous Sclerosis

Mutational Analysis and Molecular Modeling of the Allosteric Binding Site of a Novel, Selective, Noncompetitive Antagonist of the Metabotropic Glutamate 1 Receptor

Gantenerumab: a novel human anti-Aβ antibody demonstrates sustained cerebral amyloid-β binding and elicits cell-mediated removal of human amyloid-β

Basmisanil, a highly selective GABAA-α5 negative allosteric modulator: preclinical pharmacology and demonstration of functional target engagement in man

Cognitive impairment in major depression and the mGlu2 receptor as a therapeutic target

Methods for the Discovery of Novel Compounds Modulating a Gamma-Aminobutyric Acid Receptor Type A Neurotransmission

Glycine reuptake inhibitor RG1678: A pharmacologic characterization of an investigational agent for the treatment of schizophrenia

GABAA receptor-mediated neurotransmission: Not so simple after all

Selective oxytocin receptor activation prevents prefrontal circuit dysfunction and social behavioral alterations in response to chronic prefrontal cortex activation in male rats

Discovery of the imidazo[1,5-α][1,2,4].triazolo[1,5-d][1,4]benzodiazepine scaffold as a novel, potent and selective GABAA α5 inverse agonist series

Identification of Essential Residues Involved in the Glutamate Binding Pocket of the Group II Metabotropic Glutamate Receptor

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