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Molecular tweezers for lysine and arginine - powerful inhibitors of pathologic protein aggregation

Chemical communications (Cambridge, England), 2016-01, Vol.52 (76), p.11318-11334

2016

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Aromatic Interactions by Molecular Tweezers and Clips in Chemical and Biological Systems

Accounts of chemical research, 2013-04, Vol.46 (4), p.967-978

2013

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Molecular Tweezers with Additional Recognition Sites

Chemistry : a European journal, 2018-08, Vol.24 (44), p.11332-11343

2018

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Lysine-Specific Molecular Tweezers Are Broad-Spectrum Inhibitors of Assembly and Toxicity of Amyloid Proteins

Journal of the American Chemical Society, 2011-10, Vol.133 (42), p.16958-16969

2011

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Amyloid β‑Protein Assembly: The Effect of Molecular Tweezers CLR01 and CLR03

The journal of physical chemistry. B, 2015-04, Vol.119 (14), p.4831-4841

2015

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Molecular tweezers modulate 14-3-3 protein-protein interactions

Nature chemistry, 2013-03, Vol.5 (3), p.234-239

2013

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Molecular Clip and Tweezer Introduce New Mechanisms of Enzyme Inhibition

Journal of the American Chemical Society, 2008-07, Vol.130 (30), p.9824-9828

2008

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Supramolecular Mechanism of Viral Envelope Disruption by Molecular Tweezers

Journal of the American Chemical Society, 2020-10, Vol.142 (40), p.17024-17038

2020

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CLR01 protects dopaminergic neurons in vitro and in mouse models of Parkinson's disease

Nature communications, 2020-09, Vol.11 (1), p.4885-4885, Article 4885

2020

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Native Top-Down Mass Spectrometry and Ion Mobility Spectrometry of the Interaction of Tau Protein with a Molecular Tweezer Assembly Modulator

Journal of the American Society for Mass Spectrometry, 2019-01, Vol.30 (1), p.16-23

2019

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Fritz Vögtle (1939–2017)

Angewandte Chemie International Edition, 2017-03, Vol.56 (14), p.3751-3752

Klarner, Frank-Gerrit

International ed. in English, 2017

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Inhibition of Huntingtin Exon‑1 Aggregation by the Molecular Tweezer CLR01

Journal of the American Chemical Society, 2017-04, Vol.139 (16), p.5640-5643

2017

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Inhibition of Staphylococcus aureus biofilm-forming functional amyloid by molecular tweezers

Cell chemical biology, 2021-09, Vol.28 (9), p.1310-1320.e5

2021

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Molecular Tweezers and Clips as Synthetic Receptors. Molecular Recognition and Dynamics in Receptor−Substrate Complexes

Accounts of chemical research, 2003-12, Vol.36 (12), p.919-932

2003

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Comparison of Three Amyloid Assembly Inhibitors: The Sugar scyllo-Inositol, the Polyphenol Epigallocatechin Gallate, and the Molecular Tweezer CLR01

ACS chemical neuroscience, 2012-06, Vol.3 (6), p.451-458

2012

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A Molecular Tweezer Ameliorates Motor Deficits in Mice Overexpressing α-Synuclein

Neurotherapeutics, 2017-10, Vol.14 (4), p.1107-1119

2017

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The molecular tweezer CLR01 inhibits aberrant superoxide dismutase 1 (SOD1) self-assembly in vitro and in the G93A-SOD1 mouse model of ALS

The Journal of biological chemistry, 2019-03, Vol.294 (10), p.3501-3513

2019

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Major Differences between the Self-Assembly and Seeding Behavior of Heparin-Induced and in Vitro Phosphorylated Tau and Their Modulation by Potential Inhibitors

ACS chemical biology, 2019-06, Vol.14 (6), p.1363-1379

2019

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Molecular Tweezers with Varying Anions: A Comparative Study

Journal of organic chemistry, 2013-07, Vol.78 (13), p.6721-6734

2013

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Molecular Tweezers Inhibit PARP‐1 by a New Mechanism

European journal of organic chemistry, 2017-04, Vol.2017 (16), p.2223-2229

2017

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Molecular Tweezers Inhibit Islet Amyloid Polypeptide Assembly and Toxicity by a New Mechanism

ACS chemical biology, 2015-06, Vol.10 (6), p.1555-1569

2015

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A Light-Harvesting Antenna Resulting from the Self-Assembly of Five Luminescent Components: A Dendrimer, Two Clips, and Two Lanthanide Ions

Chemistry : a European journal, 2010-05, Vol.16 (20), p.6048-6055

2010

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The Lys-Specific Molecular Tweezer, CLR01, Modulates Aggregation of the Mutant p53 DNA Binding Domain and Inhibits Its Toxicity

Biochemistry (Easton), 2015-06, Vol.54 (24), p.3729-3738

2015

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Inhibition of Mutant αB Crystallin‐Induced Protein Aggregation by a Molecular Tweezer

Journal of the American Heart Association, 2017-08, Vol.6 (8), p.n/a

2017

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Molecular Lysine Tweezers Counteract Aberrant Protein Aggregation

Frontiers in chemistry, 2019-10, Vol.7, p.657

2019

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Molecular tweezers for lysine and arginine - powerful inhibitors of pathologic protein aggregation

Aromatic Interactions by Molecular Tweezers and Clips in Chemical and Biological Systems

Molecular Tweezers with Additional Recognition Sites

Lysine-Specific Molecular Tweezers Are Broad-Spectrum Inhibitors of Assembly and Toxicity of Amyloid Proteins

Amyloid β‑Protein Assembly: The Effect of Molecular Tweezers CLR01 and CLR03

Molecular tweezers modulate 14-3-3 protein-protein interactions

Molecular Clip and Tweezer Introduce New Mechanisms of Enzyme Inhibition

Supramolecular Mechanism of Viral Envelope Disruption by Molecular Tweezers

CLR01 protects dopaminergic neurons in vitro and in mouse models of Parkinson's disease

Native Top-Down Mass Spectrometry and Ion Mobility Spectrometry of the Interaction of Tau Protein with a Molecular Tweezer Assembly Modulator

Fritz Vögtle (1939–2017)

Inhibition of Huntingtin Exon‑1 Aggregation by the Molecular Tweezer CLR01

Inhibition of Staphylococcus aureus biofilm-forming functional amyloid by molecular tweezers

Molecular Tweezers and Clips as Synthetic Receptors. Molecular Recognition and Dynamics in Receptor−Substrate Complexes

Comparison of Three Amyloid Assembly Inhibitors: The Sugar scyllo-Inositol, the Polyphenol Epigallocatechin Gallate, and the Molecular Tweezer CLR01

A Molecular Tweezer Ameliorates Motor Deficits in Mice Overexpressing α-Synuclein

The molecular tweezer CLR01 inhibits aberrant superoxide dismutase 1 (SOD1) self-assembly in vitro and in the G93A-SOD1 mouse model of ALS

Major Differences between the Self-Assembly and Seeding Behavior of Heparin-Induced and in Vitro Phosphorylated Tau and Their Modulation by Potential Inhibitors

Molecular Tweezers with Varying Anions: A Comparative Study

Molecular Tweezers Inhibit PARP‐1 by a New Mechanism

Molecular Tweezers Inhibit Islet Amyloid Polypeptide Assembly and Toxicity by a New Mechanism

A Light-Harvesting Antenna Resulting from the Self-Assembly of Five Luminescent Components: A Dendrimer, Two Clips, and Two Lanthanide Ions

The Lys-Specific Molecular Tweezer, CLR01, Modulates Aggregation of the Mutant p53 DNA Binding Domain and Inhibits Its Toxicity

Inhibition of Mutant αB Crystallin‐Induced Protein Aggregation by a Molecular Tweezer

Molecular Lysine Tweezers Counteract Aberrant Protein Aggregation

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