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Drug repositioning targeting glutaminase reveals drug candidates for the treatment of Alzheimer's disease patients

Journal of translational medicine, 2023-05, Vol.21 (1), p.332-332, Article 332

2023

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Novel drug targets and molecular mechanisms for sarcopenia based on systems biology

Biomedicine & pharmacotherapy, 2024-07, Vol.176, p.116920, Article 116920

2024

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Discovery of drug targets and therapeutic agents based on drug repositioning to treat lung adenocarcinoma

Biomedicine & pharmacotherapy, 2023-05, Vol.161, p.114486-114486, Article 114486

2023

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Coexistence of open-angle glaucoma and sarcoidosis-associated optic neuropathy

BMC ophthalmology, 2023-09, Vol.23 (1), p.1-6, Article 375

2023

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Combined metabolic activators therapy ameliorates liver fat in nonalcoholic fatty liver disease patients

Molecular systems biology, 2021-10, Vol.17 (10), p.e10459-n/a

2021

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Discovery of Cell-Permeable Allosteric Inhibitors of Liver Pyruvate Kinase: Design and Synthesis of Sulfone-Based Urolithins

International journal of molecular sciences, 2024, Vol.25 (14), p.7986

2024

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The acute effect of metabolic cofactor supplementation: a potential therapeutic strategy against non-alcoholic fatty liver disease

Molecular systems biology, 2020-04, Vol.16 (4), p.e9495-n/a

2020

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Combined Metabolic Activators Accelerates Recovery in Mild‐to‐Moderate COVID‐19

Advanced science, 2021-09, Vol.8 (17), p.e2101222-n/a

2021

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A Gene Co-Expression Network-Based Drug Repositioning Approach Identifies Candidates for Treatment of Hepatocellular Carcinoma

Cancers, 2022-03, Vol.14 (6), p.1573

2022

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Characterization of an in vitro steatosis model simulating activated de novo lipogenesis in MAFLD patients

iScience, 2023-10, Vol.26 (10), p.107727-107727, Article 107727

2023

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Ellagic Acid and Its Metabolites as Potent and Selective Allosteric Inhibitors of Liver Pyruvate Kinase

Nutrients, 2023, Vol.15 (3), p.577

2023

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Exploration of Novel Urolithin C Derivatives as Non-Competitive Inhibitors of Liver Pyruvate Kinase

Pharmaceuticals (Basel, Switzerland), 2023-04, Vol.16 (5), p.668

2023

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Discovery of therapeutic agents targeting PKLR for NAFLD using drug repositioning

EBioMedicine, 2022-09, Vol.83, p.104214, Article 104214

2022

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Prediction of drug candidates for clear cell renal cell carcinoma using a systems biology-based drug repositioning approach

EBioMedicine, 2022-04, Vol.78, p.103963-103963, Article 103963

2022

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Discovery of Functional Alternatively Spliced PKM Transcripts in Human Cancers

Cancers, 2021-01, Vol.13 (2), p.348

2021

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Stratification of patients with clear cell renal cell carcinoma to facilitate drug repositioning

iScience, 2021-07, Vol.24 (7), p.102722-102722, Article 102722

2021

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Classification of clear cell renal cell carcinoma based on PKM alternative splicing

Heliyon, 2020-02, Vol.6 (2), p.e03440, Article e03440

2020

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Isolated Unilateral Ptosis Caused by Orbital Myositis Involving the Superior Rectus-Levator Muscle

Annals of Optometry and Contact Lens, 2022-06, Vol.21 (2), p.75-78

2022

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Design and evaluation of novel inhibitors for the treatment of clear cell renal cell carcinoma

Bioorganic chemistry, 2024-10, Vol.151, p.107597, Article 107597

2024

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Discovery of therapeutic agents for prostate cancer using genome-scale metabolic modeling and drug repositioning

EBioMedicine, 2019-04, Vol.42, p.386-396

2019

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Synthesis, spectroscopic characterization, DFT and molecular docking of N-(3-cyano-4,5,6,7-tetrahydrobenzo[b]thiophen-2-yl) naphthalene-1-sulfonamide derivatives

Journal of molecular structure, 2024-09, Vol.1312, p.138470, Article 138470

2024

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Open MoA: revealing the mechanism of action (MoA) based on network topology and hierarchy

Bioinformatics (Oxford, England), 2023-11, Vol.39 (11)

2023

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Binding Models of Flavonols to Human Vascular Endothelial Growth Factor Receptor 2

Bulletin of the Korean Chemical Society, 2009, 30(9), , pp.2083-2086

2009

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Cover Feature: Serendipitous Identification of a Covalent Activator of Liver Pyruvate Kinase (ChemBioChem 1/2023)

Chembiochem : a European journal of chemical biology, 2023-01, Vol.24 (1), p.n/a

2023

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Sulfone-based human liver pyruvate kinase inhibitors – Design, synthesis and in vitro bioactivity

European journal of medicinal chemistry, 2024-04, Vol.269, p.116306-116306, Article 116306

2024

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Drug repositioning targeting glutaminase reveals drug candidates for the treatment of Alzheimer's disease patients

Novel drug targets and molecular mechanisms for sarcopenia based on systems biology

Discovery of drug targets and therapeutic agents based on drug repositioning to treat lung adenocarcinoma

Coexistence of open-angle glaucoma and sarcoidosis-associated optic neuropathy

Combined metabolic activators therapy ameliorates liver fat in nonalcoholic fatty liver disease patients

Discovery of Cell-Permeable Allosteric Inhibitors of Liver Pyruvate Kinase: Design and Synthesis of Sulfone-Based Urolithins

The acute effect of metabolic cofactor supplementation: a potential therapeutic strategy against non-alcoholic fatty liver disease

Combined Metabolic Activators Accelerates Recovery in Mild‐to‐Moderate COVID‐19

A Gene Co-Expression Network-Based Drug Repositioning Approach Identifies Candidates for Treatment of Hepatocellular Carcinoma

Characterization of an in vitro steatosis model simulating activated de novo lipogenesis in MAFLD patients

Ellagic Acid and Its Metabolites as Potent and Selective Allosteric Inhibitors of Liver Pyruvate Kinase

Exploration of Novel Urolithin C Derivatives as Non-Competitive Inhibitors of Liver Pyruvate Kinase

Discovery of therapeutic agents targeting PKLR for NAFLD using drug repositioning

Prediction of drug candidates for clear cell renal cell carcinoma using a systems biology-based drug repositioning approach

Discovery of Functional Alternatively Spliced PKM Transcripts in Human Cancers

Stratification of patients with clear cell renal cell carcinoma to facilitate drug repositioning

Classification of clear cell renal cell carcinoma based on PKM alternative splicing

Isolated Unilateral Ptosis Caused by Orbital Myositis Involving the Superior Rectus-Levator Muscle

Design and evaluation of novel inhibitors for the treatment of clear cell renal cell carcinoma

Discovery of therapeutic agents for prostate cancer using genome-scale metabolic modeling and drug repositioning

Synthesis, spectroscopic characterization, DFT and molecular docking of N-(3-cyano-4,5,6,7-tetrahydrobenzo[b]thiophen-2-yl) naphthalene-1-sulfonamide derivatives

Open MoA: revealing the mechanism of action (MoA) based on network topology and hierarchy

Binding Models of Flavonols to Human Vascular Endothelial Growth Factor Receptor 2

Cover Feature: Serendipitous Identification of a Covalent Activator of Liver Pyruvate Kinase (ChemBioChem 1/2023)

Sulfone-based human liver pyruvate kinase inhibitors – Design, synthesis and in vitro bioactivity

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