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NAD+ Kinase as a Therapeutic Target in Cancer

Clinical cancer research, 2016-11, Vol.22 (21), p.5189-5195

2016

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Discovery of a small-molecule inhibitor and cellular probe of Keap1–Nrf2 protein–protein interaction

Bioorganic & medicinal chemistry letters, 2013-05, Vol.23 (10), p.3039-3043

2013

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Tumor stroma interaction is mediated by monocarboxylate metabolism

Experimental cell research, 2017-03, Vol.352 (1), p.20-33

2017

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Identification of a Non-Gatekeeper Hot Spot for Drug-Resistant Mutations in mTOR Kinase

Cell reports (Cambridge), 2015-04, Vol.11 (3), p.446-459

2015

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Modeling and antitumor studies of a modified L-penetratin peptide targeting E2F in lung cancer and prostate cancer

Oncotarget, 2018-09, Vol.9 (70), p.33249-33257

2018

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Enterococcal and streptococcal resistance to PC190723 and related compounds: Molecular insights from a FtsZ mutational analysis

Biochimie, 2013-10, Vol.95 (10), p.1880-1887

2013

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Mitochondrial Methylenetetrahydrofolate Dehydrogenase (MTHFD2) Overexpression Is Associated with Tumor Cell Proliferation and Is a Novel Target for Drug Development

Molecular cancer research, 2015-10, Vol.13 (10), p.1361-1366

2015

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A METHOD FOR CREATING NIH DATA TRAINING TABLES WITH REDCAP AND NIH XTRACT

The journal of research administration, 2024-01, Vol.55 (1), p.36-45

2024

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A G-quadruplex Stabilizer Induces M-phase Cell Cycle Arrest

The Journal of biological chemistry, 2009-08, Vol.284 (34), p.22535-22543

2009

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Topoisomerase IIβ-mediated DNA double-strand breaks : Implications in doxorubicin cardiotoxicity and prevention by dexrazoxane

Cancer research (Chicago, Ill.), 2007-09, Vol.67 (18), p.8839-8846

2007

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A second target of benzamide riboside: Dihydrofolate reductase

Cancer biology & therapy, 2012-11, Vol.13 (13), p.1290-1298

2012

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Model of Glycoprotein Hormone Receptor Ligand Binding and Signaling

The Journal of biological chemistry, 2004-10, Vol.279 (43), p.44442-44459

2004

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A Structural Model for the Ternary Cleavable Complex Formed between Human Topoisomerase I, DNA, and Camptothecin

Biochemistry (Easton), 2001-08, Vol.40 (33), p.9792-9798

2001

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A Bactericidal Guanidinomethyl Biaryl That Alters the Dynamics of Bacterial FtsZ Polymerization

Journal of medicinal chemistry, 2012-11, Vol.55 (22), p.10160-10176

2012

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Suppression of Cytosolic NADPH Pool by Thionicotinamide Increases Oxidative Stress and Synergizes with Chemotherapy

Molecular pharmacology, 2015-10, Vol.88 (4), p.720-727

2015

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Thermodynamics of aminoglycoside-rRNA recognition

Biopolymers, 2003-09, Vol.70 (1), p.58-79

2003

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A METHOD FOR CREATING NIH DATA TRAINING TABLES WITH REDCAP AND NIH XTRACT

The journal of research administration, 2024-04, Vol.55 (1), p.36-45

2024

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Recent Progress in Molecular Dynamics Simulations of Dihydrofolate Reductase

Current enzyme inhibition, 2012-09, Vol.8 (2), p.140-149

2012

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Molecular dynamics simulations in drug design

Methods in molecular biology (Clifton, N.J.), 2013, Vol.993, p.95

Kerrigan, John E

2013

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Enhanced degradation of dihydrofolate reductase through inhibition of NAD kinase by nicotinamide analogs

Molecular pharmacology, 2013-02, Vol.83 (2), p.339-353

2013

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Synthesis and G-quadruplex stabilizing properties of a series of oxazole-containing macrocycles

Bioorganic & medicinal chemistry letters, 2006-08, Vol.16 (15), p.3891-3895

2006

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Coupling of Drug Protonation to the Specific Binding of Aminoglycosides to the A Site of 16 S rRNA: Elucidation of the Number of Drug Amino Groups Involved and their Identities

Journal of molecular biology, 2003-03, Vol.326 (5), p.1373-1387

2003

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Anti-Pneumocystis Activities of Aromatic Diamidoxime Prodrugs

Antimicrobial Agents and Chemotherapy, 1998-03, Vol.42 (3), p.666-674

1998

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A novel peptide that inhibits E2F transcription and regresses prostate tumor xenografts

Oncotarget, 2014-02, Vol.5 (4), p.901-907

2014

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NAD+ Kinase as a Therapeutic Target in Cancer

Discovery of a small-molecule inhibitor and cellular probe of Keap1–Nrf2 protein–protein interaction

Tumor stroma interaction is mediated by monocarboxylate metabolism

Novel bone morphogenetic protein receptor inhibitor JL5 suppresses tumor cell survival signaling and induces regression of human lung cancer

Identification of a Non-Gatekeeper Hot Spot for Drug-Resistant Mutations in mTOR Kinase

Modeling and antitumor studies of a modified L-penetratin peptide targeting E2F in lung cancer and prostate cancer

Enterococcal and streptococcal resistance to PC190723 and related compounds: Molecular insights from a FtsZ mutational analysis

Mitochondrial Methylenetetrahydrofolate Dehydrogenase (MTHFD2) Overexpression Is Associated with Tumor Cell Proliferation and Is a Novel Target for Drug Development

A METHOD FOR CREATING NIH DATA TRAINING TABLES WITH REDCAP AND NIH XTRACT

A G-quadruplex Stabilizer Induces M-phase Cell Cycle Arrest

Topoisomerase IIβ-mediated DNA double-strand breaks : Implications in doxorubicin cardiotoxicity and prevention by dexrazoxane

A second target of benzamide riboside: Dihydrofolate reductase

Model of Glycoprotein Hormone Receptor Ligand Binding and Signaling

A Structural Model for the Ternary Cleavable Complex Formed between Human Topoisomerase I, DNA, and Camptothecin

A Bactericidal Guanidinomethyl Biaryl That Alters the Dynamics of Bacterial FtsZ Polymerization

Suppression of Cytosolic NADPH Pool by Thionicotinamide Increases Oxidative Stress and Synergizes with Chemotherapy

Thermodynamics of aminoglycoside-rRNA recognition

A METHOD FOR CREATING NIH DATA TRAINING TABLES WITH REDCAP AND NIH XTRACT

Recent Progress in Molecular Dynamics Simulations of Dihydrofolate Reductase

Molecular dynamics simulations in drug design

Enhanced degradation of dihydrofolate reductase through inhibition of NAD kinase by nicotinamide analogs

Synthesis and G-quadruplex stabilizing properties of a series of oxazole-containing macrocycles

Coupling of Drug Protonation to the Specific Binding of Aminoglycosides to the A Site of 16 S rRNA: Elucidation of the Number of Drug Amino Groups Involved and their Identities

Anti-Pneumocystis Activities of Aromatic Diamidoxime Prodrugs

A novel peptide that inhibits E2F transcription and regresses prostate tumor xenografts

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