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Excess Provisional Extracellular Matrix: A Common Factor in Bicuspid Aortic Valve Formation

Journal of cardiovascular development and disease, 2021-08, Vol.8 (8), p.92

Kern, Christine B.

2021

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Origin and fate of cardiac mesenchyme

Developmental dynamics, 2008-10, Vol.237 (10), p.2804-2819

2008

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Periostin regulates collagen fibrillogenesis and the biomechanical properties of connective tissues

Journal of cellular biochemistry, 2007-06, Vol.101 (3), p.695-711

2007

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Altered versican cleavage in ADAMTS5 deficient mice; A novel etiology of myxomatous valve disease

Developmental biology, 2011-09, Vol.357 (1), p.152-164

2011

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Small leucine‐rich proteoglycans exhibit unique spatiotemporal expression profiles during cardiac valve development

Developmental dynamics, 2014-04, Vol.243 (4), p.601-611

2014

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Insufficient versican cleavage and Smad2 phosphorylation results in bicuspid aortic and pulmonary valves

Journal of molecular and cellular cardiology, 2013-07, Vol.60, p.50-59

2013

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Inhibition of class I histone deacetylase activity represses matrix metalloproteinase-2 and -9 expression and preserves LV function postmyocardial infarction

American journal of physiology. Heart and circulatory physiology, 2015-06, Vol.308 (11), p.H1391-H1401

2015

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Fibulin-1 Binds to Fibroblast Growth Factor 8 with High Affinity: EFFECTS ON EMBRYO SURVIVAL

The Journal of biological chemistry, 2016-09, Vol.291 (36), p.18730-18739

2016

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Imbalanced expression of Vcan mRNA splice form proteins alters heart morphology and cellular protein profiles

PloS one, 2014-02, Vol.9 (2), p.e89133-e89133

2014

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Increased Proteoglycanases in Pulmonary Valves after Birth Correlate with Extracellular Matrix Maturation and Valve Sculpting

Journal of cardiovascular development and disease, 2023-01, Vol.10 (1), p.27

2023

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Fibulin-1 is required for morphogenesis of neural crest-derived structures

Developmental biology, 2008-07, Vol.319 (2), p.336-345

2008

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Proteolytic cleavage of versican during cardiac cushion morphogenesis

Developmental dynamics, 2006-08, Vol.235 (8), p.2238-2247

2006

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Fibulin-1 is required during cardiac ventricular morphogenesis for versican cleavage, suppression of ErbB2 and Erk1/2 activation, and to attenuate trabecular cardiomyocyte proliferation

Developmental dynamics, 2012-02, Vol.241 (2), p.303-314

2012

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Adamts5 -/- Mice Exhibit Altered Aggrecan Proteolytic Profiles That Correlate With Ascending Aortic Anomalies

Arteriosclerosis, thrombosis, and vascular biology, 2019-10, Vol.39 (10), p.2067-2081

2019

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Cartilage link protein 1 (Crtl1), an extracellular matrix component playing an important role in heart development

Developmental biology, 2007-10, Vol.310 (2), p.291-303

2007

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Versican proteolysis mediates myocardial regression during outflow tract development

Developmental dynamics, 2007-03, Vol.236 (3), p.671-683

2007

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The adaptive response of the mandibular condyle to increased load is disrupted by ADAMTS5 deficiency

Connective tissue research, 2023-01, Vol.64 (1), p.93-104

2023

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Intercalated cushion cells within the cardiac outflow tract are derived from the myocardial troponin T type 2 (Tnnt2) Cre lineage

Developmental dynamics, 2018-08, Vol.247 (8), p.1005-1017

2018

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Development of Aortic Valves With 2 and 3 Leaflets

Journal of the American College of Cardiology, 2009-12, Vol.54 (24), p.2319-2320, Article 2319

2009

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Versican accumulation drives Nos2 induction and aortic disease in Marfan syndrome via Akt activation

EMBO molecular medicine, 2024-01, Vol.16 (1), p.132-157

2024

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Lumican deficiency results in cardiomyocyte hypertrophy with altered collagen assembly

Journal of molecular and cellular cardiology, 2015-07, Vol.84, p.70-80

2015

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Reduced versican cleavage due to Adamts9 haploinsufficiency is associated with cardiac and aortic anomalies

Matrix biology, 2010-05, Vol.29 (4), p.304-316

2010

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Development of myotendinous‐like junctions that anchor cardiac valves requires fibromodulin and lumican

Developmental dynamics, 2016-10, Vol.245 (10), p.1029-1042

2016

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Histone deacetylases facilitate sodium/calcium exchanger up‐regulation in adult cardiomyocytes

The FASEB journal, 2009-11, Vol.23 (11), p.3851-3864

2009

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Maladaptive matrix remodeling and regional biomechanical dysfunction in a mouse model of aortic valve disease

Matrix biology, 2012-04, Vol.31 (3), p.197-205

2012

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Excess Provisional Extracellular Matrix: A Common Factor in Bicuspid Aortic Valve Formation

Origin and fate of cardiac mesenchyme

Periostin regulates collagen fibrillogenesis and the biomechanical properties of connective tissues

Altered versican cleavage in ADAMTS5 deficient mice; A novel etiology of myxomatous valve disease

Small leucine‐rich proteoglycans exhibit unique spatiotemporal expression profiles during cardiac valve development

Insufficient versican cleavage and Smad2 phosphorylation results in bicuspid aortic and pulmonary valves

Inhibition of class I histone deacetylase activity represses matrix metalloproteinase-2 and -9 expression and preserves LV function postmyocardial infarction

Fibulin-1 Binds to Fibroblast Growth Factor 8 with High Affinity: EFFECTS ON EMBRYO SURVIVAL

Imbalanced expression of Vcan mRNA splice form proteins alters heart morphology and cellular protein profiles

Increased Proteoglycanases in Pulmonary Valves after Birth Correlate with Extracellular Matrix Maturation and Valve Sculpting

Fibulin-1 is required for morphogenesis of neural crest-derived structures

Proteolytic cleavage of versican during cardiac cushion morphogenesis

Fibulin-1 is required during cardiac ventricular morphogenesis for versican cleavage, suppression of ErbB2 and Erk1/2 activation, and to attenuate trabecular cardiomyocyte proliferation

Adamts5 -/- Mice Exhibit Altered Aggrecan Proteolytic Profiles That Correlate With Ascending Aortic Anomalies

Cartilage link protein 1 (Crtl1), an extracellular matrix component playing an important role in heart development

Versican proteolysis mediates myocardial regression during outflow tract development

The adaptive response of the mandibular condyle to increased load is disrupted by ADAMTS5 deficiency

Intercalated cushion cells within the cardiac outflow tract are derived from the myocardial troponin T type 2 (Tnnt2) Cre lineage

Development of Aortic Valves With 2 and 3 Leaflets

Versican accumulation drives Nos2 induction and aortic disease in Marfan syndrome via Akt activation

Lumican deficiency results in cardiomyocyte hypertrophy with altered collagen assembly

Reduced versican cleavage due to Adamts9 haploinsufficiency is associated with cardiac and aortic anomalies

Development of myotendinous‐like junctions that anchor cardiac valves requires fibromodulin and lumican

Histone deacetylases facilitate sodium/calcium exchanger up‐regulation in adult cardiomyocytes

Maladaptive matrix remodeling and regional biomechanical dysfunction in a mouse model of aortic valve disease

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