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Mimicking hypoxia to treat anemia: HIF-stabilizer BAY 85-3934 (Molidustat) stimulates erythropoietin production without hypertensive effects

PloS one, 2014-11, Vol.9 (11), p.e111838-e111838

2014

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COSMOmic: A Mechanistic Approach to the Calculation of Membrane−Water Partition Coefficients and Internal Distributions within Membranes and Micelles

The journal of physical chemistry. B, 2008-09, Vol.112 (38), p.12148-12157

2008

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Discovery of Molidustat (BAY 85‐3934): A Small‐Molecule Oral HIF‐Prolyl Hydroxylase (HIF‐PH) Inhibitor for the Treatment of Renal Anemia

ChemMedChem, 2018-05, Vol.13 (10), p.988-1003

2018

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A Physiological Model for the Estimation of the Fraction Dose Absorbed in Humans

Journal of medicinal chemistry, 2004-07, Vol.47 (16), p.4022-4031

2004

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Functional Characterization and Comparison of the Outer Blood-Retina Barrier and the Blood-Brain Barrier

Investigative ophthalmology & visual science, 2005-03, Vol.46 (3), p.1047-1053

2005

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A physiologic model for simulating gastrointestinal flow and drug absorption in rats

Pharmaceutical research, 2003-11, Vol.20 (11), p.1766-1771

2003

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Effects of different pulmonary vasodilators on arterial saturation in a model of pulmonary hypertension

PloS one, 2013-08, Vol.8 (8), p.e73502-e73502

2013

Volltextzugriff (PDF)

In Silico ADMET Traffic Lights as a Tool for the Prioritization of HTS Hits

ChemMedChem, 2006-11, Vol.1 (11), p.1229-1236

2006

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In Silico Prediction of Buffer Solubility Based on Quantum-Mechanical and HQSAR- and Topology-Based Descriptors

Journal of chemical information and modeling, 2006-03, Vol.46 (2), p.648-658

2006

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Biphenyls as potent vitronectin receptor antagonists. Part 3: Squaric acid amides

Bioorganic & medicinal chemistry letters, 2007-11, Vol.17 (22), p.6151-6154

2007

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Effects of Different Pulmonary Vasodilators on Arterial Saturation in a Model of Pulmonary Hypertension: e73502

PloS one, 2013-08, Vol.8 (8)

2013

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Prediction of human clearance (CL) and volume of distribution (VD)

Drug discovery today. Technologies, 2004-12, Vol.1 (4), p.389-395

Keldenich, Jörg

2004

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Front Cover: Discovery of Molidustat (BAY 85‐3934): A Small‐Molecule Oral HIF‐Prolyl Hydroxylase (HIF‐PH) Inhibitor for the Treatment of Renal Anemia (ChemMedChem 10/2018)

ChemMedChem, 2018-05, Vol.13 (10), p.981-981

2018

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Volume to dissolve applied dose (VDAD) and apparent dissolution rate (ADR): Tools to predict in vivo bioavailability from orally applied drug suspensions

European journal of pharmaceutics and biopharmaceutics, 2011-08, Vol.78 (3), p.522-530

2011

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Multilamellar liposomes and solid-supported lipid membranes (TRANSIL): Screening of lipid-water partitioning toward a high-throughput scale

Pharmaceutical research, 2001-12, Vol.18 (12), p.1782-1788

2001

Volltextzugriff (PDF)

CypScore: Quantitative Prediction of Reactivity toward Cytochromes P450 Based on Semiempirical Molecular Orbital Theory

ChemMedChem, 2009-04, Vol.4 (4), p.657-669

2009

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Leukotriene Synthesis Inhibitors of the Quinoline Type: Parameters for the Optimization of Efficacy

European journal of medicinal chemistry, 1995, Vol.30, p.441s-451s

1995

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Estimation of Physicochemical and ADME Parameters

Handbook of Combinatorial Chemistry, 2002, p.743-760

2002

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Mimicking hypoxia to treat anemia: HIF-stabilizer BAY 85-3934 (Molidustat) stimulates erythropoietin production without hypertensive effects

COSMOmic: A Mechanistic Approach to the Calculation of Membrane−Water Partition Coefficients and Internal Distributions within Membranes and Micelles

Discovery of Molidustat (BAY 85‐3934): A Small‐Molecule Oral HIF‐Prolyl Hydroxylase (HIF‐PH) Inhibitor for the Treatment of Renal Anemia

A Physiological Model for the Estimation of the Fraction Dose Absorbed in Humans

Functional Characterization and Comparison of the Outer Blood-Retina Barrier and the Blood-Brain Barrier

A physiologic model for simulating gastrointestinal flow and drug absorption in rats

Effects of different pulmonary vasodilators on arterial saturation in a model of pulmonary hypertension

In Silico ADMET Traffic Lights as a Tool for the Prioritization of HTS Hits

In Silico Prediction of Buffer Solubility Based on Quantum-Mechanical and HQSAR- and Topology-Based Descriptors

Biphenyls as potent vitronectin receptor antagonists. Part 3: Squaric acid amides

Effects of Different Pulmonary Vasodilators on Arterial Saturation in a Model of Pulmonary Hypertension: e73502

Prediction of human clearance (CL) and volume of distribution (VD)

Front Cover: Discovery of Molidustat (BAY 85‐3934): A Small‐Molecule Oral HIF‐Prolyl Hydroxylase (HIF‐PH) Inhibitor for the Treatment of Renal Anemia (ChemMedChem 10/2018)

Volume to dissolve applied dose (VDAD) and apparent dissolution rate (ADR): Tools to predict in vivo bioavailability from orally applied drug suspensions

Multilamellar liposomes and solid-supported lipid membranes (TRANSIL): Screening of lipid-water partitioning toward a high-throughput scale

CypScore: Quantitative Prediction of Reactivity toward Cytochromes P450 Based on Semiempirical Molecular Orbital Theory

Leukotriene Synthesis Inhibitors of the Quinoline Type: Parameters for the Optimization of Efficacy

Estimation of Physicochemical and ADME Parameters

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