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Phosphorylation of Ser-129 Is the Dominant Pathological Modification of α-Synuclein in Familial and Sporadic Lewy Body Disease

The Journal of biological chemistry, 2006-10, Vol.281 (40), p.29739-29752

2006

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Design, synthesis, and structure–activity relationship of novel orally efficacious pyrazole/sulfonamide based dihydroquinoline γ-secretase inhibitors

Bioorganic & medicinal chemistry letters, 2009-09, Vol.19 (17), p.4920-4923

2009

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Discovery of sulfonamide–pyrazole γ-secretase inhibitors

Bioorganic & medicinal chemistry letters, 2010-04, Vol.20 (7), p.2148-2150

2010

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Discovery of ( R )-4-Cyclopropyl-7,8-difluoro-5-(4-(trifluoromethyl)phenylsulfonyl)-4,5-dihydro-1 H -pyrazolo[4,3- c ]quinoline (ELND006) and ( R )-4-Cyclopropyl-8-fluoro-5-(6-(trifluoromethyl)pyridin-3-ylsulfonyl)-4,5-dihydro-2 H -pyrazolo[4,3- c ]quinoline (ELND007): Metabolically Stable γ-Secretase Inhibitors that Selectively Inhibit the Production of Amyloid-β over Notch

Journal of medicinal chemistry, 2013-07, Vol.56 (13), p.5261-5274

2013

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Discovery of (R)‑4-Cyclopropyl-7,8-difluoro-5-(4-(trifluoromethyl)phenylsulfonyl)-4,5-dihydro‑1H‑pyrazolo[4,3‑c]quinoline (ELND006) and (R)‑4-Cyclopropyl-8-fluoro-5-(6-(trifluoromethyl)pyridin-3-ylsulfonyl)-4,5-dihydro‑2H‑pyrazolo[4,3‑c]quinoline (ELND007): Metabolically Stable γ‑Secretase Inhibitors that Selectively Inhibit the Production of Amyloid‑β over Notch

Journal of medicinal chemistry, 2013-07, Vol.56 (13), p.5261-5274

2013

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Amyloid precursor protein selective gamma-secretase inhibitors for treatment of Alzheimer's disease

Alzheimer's research & therapy, 2010-12, Vol.2 (6), p.36-36

2010

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Cleavage of Amyloid β Peptide During Constitutive Processing of Its Precursor

Science (American Association for the Advancement of Science), 1990-06, Vol.248 (4959), p.1122-1124

1990

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Corrigendum to “Design, synthesis, and structure–activity relationship of novel orally efficacious pyrazole/sulfonamide based dihydroquinoline γ-secretase inhibitors” [Bioorg. Med. Chem. Lett. 19 (2009) 4920]

Bioorganic & medicinal chemistry letters, 2010-12, Vol.20 (24), p.7553-7553

2010

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Design, synthesis, and structure-activity relationship of novel orally efficacious pyrazole/sulfonamide based dihydroquinoline g-secretase inhibitors

Bioorganic & medicinal chemistry letters, 2009-09, Vol.19 (17), p.4920-4923

2009

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Design, synthesis, and structure-activity relationship of novel orally efficacious pyrazole/sulfonamide based dihydroquinoline y-secretase inhibitors

Bioorganic & medicinal chemistry letters, 2009, Vol.19 (17), p.4920-4923

2009

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Exact cleavage site of Alzheimer amyloid precursor in neuronal PC-12 cells

Neuroscience letters, 1991-07, Vol.128 (1), p.126-128

1991

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Phosphorylation of Ser-129 Is the Dominant Pathological Modification of Î±-Synuclein in Familial and Sporadic Lewy Body Disease

The Journal of biological chemistry, 2006-10, Vol.281 (40), p.29739

2006

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P4-183 Molecular determinants of substrate recognition by the Alzheimer amyloid peptide generating protease, β-secretase (BACE)

Neurobiology of aging, 2004-07, Vol.25, p.S527-S527

2004

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Amino Acid Sequence of Human Platelet Factor 4

Proceedings of the National Academy of Sciences - PNAS, 1977-06, Vol.74 (6), p.2256-2258

1977

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Cleavage of Amyloid (beta) Peptide During Constitutive Processing of Its Precursor

Science (American Association for the Advancement of Science), 1990-06, Vol.248 (4959), p.1122-1122

1990

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Cleavage of amyloid B peptide during constitutive processing of its precursor

Science (American Association for the Advancement of Science), 1990-06, Vol.248 (4959), p.1122

1990

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Detection and Kinetic Behavior of Preproinsulin in Pancreatic Islets

Proceedings of the National Academy of Sciences - PNAS, 1978-03, Vol.75 (3), p.1260-1264

1978

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The covalent structure of pig kidney fructose 1,6-bisphosphatase: sequence of the 60-residue NH2-terminal peptide produced by digestion with subtilisin

Archives of biochemistry and biophysics, 1981-07, Vol.209 (2), p.687-696

1981

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Crotalus adamanteus phospholipase A 2-α: Subunit structure, NH 2-terminal sequence, and homology with other phospholipases

Archives of biochemistry and biophysics, 1975, Vol.167 (2), p.706-717

1975

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The covalent structure of pig kidney fructose 1,6-bisphosphatase: sequence of the 60-residue NH 2-terminal peptide produced by digestion with subtilisin

Archives of biochemistry and biophysics, 1981, Vol.209 (2), p.687-696

1981

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Crotalus adamanteus phospholipase A2-alpha: subunit structure. NH2-terminal sequence, and homology with other phospholipases

Archives of biochemistry and biophysics, 1975-04, Vol.167 (2), p.706-717

1975

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Arylphorin, a new protein from Hyalophora cecropia: Comparisons with calliphorin and manducin

Insect biochemistry, 1983, Vol.13 (6), p.601-613

1983

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Partial structural analysis of the basic chromosomal protein of rat spermatozoa

Biochimica et biophysica acta. Protein structure, 1976-04, Vol.427 (2), p.752-757

1976

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Juvenile hormone carrier protein of Manduca sexta haemolymph. Improved purification procedure; protein modification studies and sequence of the amino terminus of the protein

Insect biochemistry, 1982, Vol.12 (6), p.643-650

1982

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Statewide Analysis Reveals Period of Well-Child Visit Attendance for Earlier Diagnosis of Autism Spectrum Disorder

The Journal of pediatrics, 2022-02, Vol.241, p.181-187.e1

2022

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Phosphorylation of Ser-129 Is the Dominant Pathological Modification of α-Synuclein in Familial and Sporadic Lewy Body Disease

Design, synthesis, and structure–activity relationship of novel orally efficacious pyrazole/sulfonamide based dihydroquinoline γ-secretase inhibitors

Discovery of sulfonamide–pyrazole γ-secretase inhibitors

Amyloid precursor protein selective gamma-secretase inhibitors for treatment of Alzheimer's disease

Cleavage of Amyloid β Peptide During Constitutive Processing of Its Precursor

Corrigendum to “Design, synthesis, and structure–activity relationship of novel orally efficacious pyrazole/sulfonamide based dihydroquinoline γ-secretase inhibitors” [Bioorg. Med. Chem. Lett. 19 (2009) 4920]

Design, synthesis, and structure-activity relationship of novel orally efficacious pyrazole/sulfonamide based dihydroquinoline g-secretase inhibitors

Design, synthesis, and structure-activity relationship of novel orally efficacious pyrazole/sulfonamide based dihydroquinoline y-secretase inhibitors

Exact cleavage site of Alzheimer amyloid precursor in neuronal PC-12 cells

Phosphorylation of Ser-129 Is the Dominant Pathological Modification of Î±-Synuclein in Familial and Sporadic Lewy Body Disease

P4-183 Molecular determinants of substrate recognition by the Alzheimer amyloid peptide generating protease, β-secretase (BACE)

Amino Acid Sequence of Human Platelet Factor 4

Cleavage of Amyloid (beta) Peptide During Constitutive Processing of Its Precursor

Cleavage of amyloid B peptide during constitutive processing of its precursor

Detection and Kinetic Behavior of Preproinsulin in Pancreatic Islets

The covalent structure of pig kidney fructose 1,6-bisphosphatase: sequence of the 60-residue NH2-terminal peptide produced by digestion with subtilisin

Crotalus adamanteus phospholipase A 2-α: Subunit structure, NH 2-terminal sequence, and homology with other phospholipases

The covalent structure of pig kidney fructose 1,6-bisphosphatase: sequence of the 60-residue NH 2-terminal peptide produced by digestion with subtilisin

Crotalus adamanteus phospholipase A2-alpha: subunit structure. NH2-terminal sequence, and homology with other phospholipases

Arylphorin, a new protein from Hyalophora cecropia: Comparisons with calliphorin and manducin

Partial structural analysis of the basic chromosomal protein of rat spermatozoa

Juvenile hormone carrier protein of Manduca sexta haemolymph. Improved purification procedure; protein modification studies and sequence of the amino terminus of the protein

Statewide Analysis Reveals Period of Well-Child Visit Attendance for Earlier Diagnosis of Autism Spectrum Disorder

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