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Adipose Tissue Selective Insulin Receptor Knockout Protects against Obesity and Obesity-Related Glucose Intolerance

Developmental cell, 2002-07, Vol.3 (1), p.25-38

2002

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Tissue-specific Ablation of the GLUT4 Glucose Transporter or the Insulin Receptor Challenges Assumptions about Insulin Action and Glucose Homeostasis

The Journal of biological chemistry, 2003-09, Vol.278 (36), p.33609-33612

2003

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Loss of Insulin Signaling in Hepatocytes Leads to Severe Insulin Resistance and Progressive Hepatic Dysfunction

Molecular cell, 2000-07, Vol.6 (1), p.87-97

2000

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Regulation of Myocardial Contractility and Cell Size by Distinct PI3K-PTEN Signaling Pathways

Cell, 2002-09, Vol.110 (6), p.737-749

2002

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A Muscle-Specific Insulin Receptor Knockout Exhibits Features of the Metabolic Syndrome of NIDDM without Altering Glucose Tolerance

Molecular cell, 1998-11, Vol.2 (5), p.559-569

1998

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Deficiency of PDK1 in cardiac muscle results in heart failure and increased sensitivity to hypoxia

The EMBO journal, 2003-09, Vol.22 (18), p.4666-4676

2003

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Diabetes primes neutrophils to undergo NETosis, which impairs wound healing

Nature medicine, 2015-07, Vol.21 (7), p.815-819

2015

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Characterization of Multiple Signaling Pathways of Insulin in the Regulation of Vascular Endothelial Growth Factor Expression in Vascular Cells and Angiogenesis

The Journal of biological chemistry, 2003-08, Vol.278 (34), p.31964-31971

2003

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Effect of cholesterol reduction on receptor signaling in neurons

The Journal of biological chemistry, 2016-07, Vol.291 (30), p.15910-15910

2016

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Tissue-Specific Knockout of the Insulin Receptor in Pancreatic β Cells Creates an Insulin Secretory Defect Similar to that in Type 2 Diabetes

Cell, 1999-02, Vol.96 (3), p.329-339

1999

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Magnitude and determinants of coronary artery disease in juvenile-onset, insulin-dependent diabetes mellitus

The American journal of cardiology, 1987-04, Vol.59 (8), p.750-755

1987

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The changing natural history of nephropathy in type I Diabetes

The American journal of medicine, 1985-05, Vol.78 (5), p.785-794

1985

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Characterization of Rad, a New Member of Ras/GTPase Superfamily, and Its Regulation by a Unique GTPase-activating protein (GAP)-like Activity (∗)

The Journal of biological chemistry, 1995-03, Vol.270 (9), p.4805-4812

1995

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Selective Insulin Signaling through A and B Insulin Receptors Regulates Transcription of Insulin and Glucokinase Genes in Pancreatic β Cells

Molecular cell, 2001-03, Vol.7 (3), p.559-570

2001

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Development of a Novel Polygenic Model of NIDDM in Mice Heterozygous for IR and IRS-1 Null Alleles

Cell, 1997-02, Vol.88 (4), p.561-572

1997

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Role of suppressors of cytokine signaling SOCS-1 and SOCS-3 in hepatic steatosis and the metabolic syndrome

Hepatology research, 2005-10, Vol.33 (2), p.185-192

2005

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Roles of Insulin Receptor Substrate-1, Phosphatidylinositol 3-Kinase, and Release of Intracellular Ca2+ Stores in Insulin-stimulated Insulin Secretion in β-Cells

The Journal of biological chemistry, 2000-07, Vol.275 (29), p.22331-22338

2000

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Defining the Early Events in Insulin Action at a Molecular Level

Journal of the Japan Diabetes Society, 1992/04/17, Vol.35(sppl1), pp.88-88

Kahn, C.Ronald

1992

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Bi-directional Regulation of Brown Fat Adipogenesis by the Insulin Receptor

The Journal of biological chemistry, 2003-08, Vol.278 (35), p.33377-33383

2003

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Mice lacking insulin or insulin-like growth factor 1 receptors in vascular endothelial cells maintain normal blood–brain barrier

Biochemical and biophysical research communications, 2004-04, Vol.317 (2), p.315-320

2004

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Gab-1-mediated IGF-1 Signaling in IRS-1-deficient 3T3 Fibroblasts

The Journal of biological chemistry, 2000-04, Vol.275 (14), p.10545-10550

2000

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Insulin Stimulates p70 S6 Kinase in the Nucleus of Cells

Biochemical and biophysical research communications, 1997-05, Vol.234 (3), p.681-685

1997

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The Ras-Related Protein Rad Associates with the Cytoskeleton in a Non-Lipid-Dependent Manner

Experimental cell research, 1998-08, Vol.242 (2), p.391-400

1998

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Lessons from transgenic and knockout animals about noninsulin-dependent diabetes mellitus

Trends in Endocrinology & Metabolism, 1996-11, Vol.7 (9), p.311-319

1996

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Cloning of the mouse insulin receptor substrate-1 (IRS-1) gene and complete sequence of mouse IRS-1

Biochimica et biophysica acta, 1994-04, Vol.1221 (3), p.353-356

1994

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Adipose Tissue Selective Insulin Receptor Knockout Protects against Obesity and Obesity-Related Glucose Intolerance

Tissue-specific Ablation of the GLUT4 Glucose Transporter or the Insulin Receptor Challenges Assumptions about Insulin Action and Glucose Homeostasis

Loss of Insulin Signaling in Hepatocytes Leads to Severe Insulin Resistance and Progressive Hepatic Dysfunction

Regulation of Myocardial Contractility and Cell Size by Distinct PI3K-PTEN Signaling Pathways

A Muscle-Specific Insulin Receptor Knockout Exhibits Features of the Metabolic Syndrome of NIDDM without Altering Glucose Tolerance

Deficiency of PDK1 in cardiac muscle results in heart failure and increased sensitivity to hypoxia

Diabetes primes neutrophils to undergo NETosis, which impairs wound healing

Characterization of Multiple Signaling Pathways of Insulin in the Regulation of Vascular Endothelial Growth Factor Expression in Vascular Cells and Angiogenesis

Effect of cholesterol reduction on receptor signaling in neurons

Tissue-Specific Knockout of the Insulin Receptor in Pancreatic β Cells Creates an Insulin Secretory Defect Similar to that in Type 2 Diabetes

Magnitude and determinants of coronary artery disease in juvenile-onset, insulin-dependent diabetes mellitus

The changing natural history of nephropathy in type I Diabetes

Characterization of Rad, a New Member of Ras/GTPase Superfamily, and Its Regulation by a Unique GTPase-activating protein (GAP)-like Activity (∗)

Selective Insulin Signaling through A and B Insulin Receptors Regulates Transcription of Insulin and Glucokinase Genes in Pancreatic β Cells

Development of a Novel Polygenic Model of NIDDM in Mice Heterozygous for IR and IRS-1 Null Alleles

Role of suppressors of cytokine signaling SOCS-1 and SOCS-3 in hepatic steatosis and the metabolic syndrome

Roles of Insulin Receptor Substrate-1, Phosphatidylinositol 3-Kinase, and Release of Intracellular Ca2+ Stores in Insulin-stimulated Insulin Secretion in β-Cells

Defining the Early Events in Insulin Action at a Molecular Level

Bi-directional Regulation of Brown Fat Adipogenesis by the Insulin Receptor

Mice lacking insulin or insulin-like growth factor 1 receptors in vascular endothelial cells maintain normal blood–brain barrier

Gab-1-mediated IGF-1 Signaling in IRS-1-deficient 3T3 Fibroblasts

Insulin Stimulates p70 S6 Kinase in the Nucleus of Cells

The Ras-Related Protein Rad Associates with the Cytoskeleton in a Non-Lipid-Dependent Manner

Lessons from transgenic and knockout animals about noninsulin-dependent diabetes mellitus

Cloning of the mouse insulin receptor substrate-1 (IRS-1) gene and complete sequence of mouse IRS-1

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