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Whole Exome Sequencing Identifies TSC1/TSC2 Biallelic Loss as the Primary and Sufficient Driver Event for Renal Angiomyolipoma Development

PLoS genetics, 2016-08, Vol.12 (8), p.e1006242

2016

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TBC1D7 Is a Third Subunit of the TSC1-TSC2 Complex Upstream of mTORC1

Molecular cell, 2012-08, Vol.47 (4), p.535-546

2012

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Genetic Etiologies, Diagnosis, and Treatment of Tuberous Sclerosis Complex

Annual review of genomics and human genetics, 2019-08, Vol.20 (1), p.217-240

2019

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Midkine expression by stem-like tumor cells drives persistence to mTOR inhibition and an immune-suppressive microenvironment

Nature communications, 2022-08, Vol.13 (1), p.5018-5018, Article 5018

2022

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A Pan-Cancer Proteogenomic Atlas of PI3K/AKT/mTOR Pathway Alterations

Cancer cell, 2017-06, Vol.31 (6), p.820-832.e3

2017

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Akt Stimulates Hepatic SREBP1c and Lipogenesis through Parallel mTORC1-Dependent and Independent Pathways

Cell metabolism, 2011-07, Vol.14 (1), p.21-32

2011

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An APOBEC3A hypermutation signature is distinguishable from the signature of background mutagenesis by APOBEC3B in human cancers

Nature genetics, 2015-09, Vol.47 (9), p.1067-1072

2015

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Perivascular epithelioid cell neoplasms: pathology and pathogenesis

Human pathology, 2010, Vol.41 (1), p.1-15

2010

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Mosaic and Intronic Mutations in TSC1/TSC2 Explain the Majority of TSC Patients with No Mutation Identified by Conventional Testing

PLoS genetics, 2015-11, Vol.11 (11), p.e1005637-e1005637

2015

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Molecular Testing Guideline for Selection of Lung Cancer Patients for EGFR and ALK Tyrosine Kinase Inhibitors: Guideline from the College of American Pathologists, International Association for the Study of Lung Cancer, and Association for Molecular Pathology

Journal of thoracic oncology, 2013-07, Vol.8 (7), p.823-859

2013

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MET IHC Is a Poor Screen for MET Amplification or MET Exon 14 Mutations in Lung Adenocarcinomas: Data from a Tri-Institutional Cohort of the Lung Cancer Mutation Consortium

Journal of thoracic oncology, 2019-09, Vol.14 (9), p.1666-1671

2019

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Using multiplexed assays of oncogenic drivers in lung cancers to select targeted drugs

JAMA : the journal of the American Medical Association, 2014-05, Vol.311 (19), p.1998

2014

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Coordinated regulation of protein synthesis and degradation by mTORC1

Nature (London), 2014-09, Vol.513 (7518), p.440-443

2014

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Mutational Analysis of 472 Urothelial Carcinoma Across Grades and Anatomic Sites

Clinical cancer research, 2019-04, Vol.25 (8), p.2458-2470

2019

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Response and Acquired Resistance to Everolimus in Anaplastic Thyroid Cancer

The New England journal of medicine, 2014-10, Vol.371 (15), p.1426-1433

2014

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mTORC1 upregulates B7-H3/CD276 to inhibit antitumor T cells and drive tumor immune evasion

Nature communications, 2023-03, Vol.14 (1), p.1214-1214, Article 1214

2023

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Molecular testing guideline for selection of lung cancer patients for EGFR and ALK tyrosine kinase inhibitors: guideline from the College of American Pathologists, International Association for the Study of Lung Cancer, and Association for Molecular Pathology

Archives of pathology & laboratory medicine (1976), 2013-06, Vol.137 (6), p.828-860

2013

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Invasive Bladder Cancer: Genomic Insights and Therapeutic Promise

Clinical cancer research, 2015-10, Vol.21 (20), p.4514-4524

2015

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Somatic Mutations Activating the mTOR Pathway in Dorsal Telencephalic Progenitors Cause a Continuum of Cortical Dysplasias

Cell reports (Cambridge), 2017-12, Vol.21 (13), p.3754-3766

2017

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Reversal of learning deficits in a Tsc2 +/− mouse model of tuberous sclerosis

Nature medicine, 2008-08, Vol.14 (8), p.843-848

2008

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Response of a Neuronal Model of Tuberous Sclerosis to Mammalian Target of Rapamycin (mTOR) Inhibitors: Effects on mTORC1 and Akt Signaling Lead to Improved Survival and Function

The Journal of neuroscience, 2008-05, Vol.28 (21), p.5422-5432

2008

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Pan-Cancer Molecular Classes Transcending Tumor Lineage Across 32 Cancer Types, Multiple Data Platforms, and over 10,000 Cases

Clinical cancer research, 2018-05, Vol.24 (9), p.2182-2193

2018

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Mammalian target of rapamycin pathway mutations cause hemimegalencephaly and focal cortical dysplasia

Annals of neurology, 2015-04, Vol.77 (4), p.720-725

2015

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Multi-institutional Oncogenic Driver Mutation Analysis in Lung Adenocarcinoma: The Lung Cancer Mutation Consortium Experience

Journal of thoracic oncology, 2015-05, Vol.10 (5), p.768-777

2015

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Whole Exome Sequencing Identifies TSC1/TSC2 Biallelic Loss as the Primary and Sufficient Driver Event for Renal Angiomyolipoma Development

TBC1D7 Is a Third Subunit of the TSC1-TSC2 Complex Upstream of mTORC1

Genetic Etiologies, Diagnosis, and Treatment of Tuberous Sclerosis Complex

Midkine expression by stem-like tumor cells drives persistence to mTOR inhibition and an immune-suppressive microenvironment

A Pan-Cancer Proteogenomic Atlas of PI3K/AKT/mTOR Pathway Alterations

Distinct patterns of somatic genome alterations in lung adenocarcinomas and squamous cell carcinomas

Akt Stimulates Hepatic SREBP1c and Lipogenesis through Parallel mTORC1-Dependent and Independent Pathways

An APOBEC3A hypermutation signature is distinguishable from the signature of background mutagenesis by APOBEC3B in human cancers

Perivascular epithelioid cell neoplasms: pathology and pathogenesis

Mosaic and Intronic Mutations in TSC1/TSC2 Explain the Majority of TSC Patients with No Mutation Identified by Conventional Testing

Molecular Testing Guideline for Selection of Lung Cancer Patients for EGFR and ALK Tyrosine Kinase Inhibitors: Guideline from the College of American Pathologists, International Association for the Study of Lung Cancer, and Association for Molecular Pathology

MET IHC Is a Poor Screen for MET Amplification or MET Exon 14 Mutations in Lung Adenocarcinomas: Data from a Tri-Institutional Cohort of the Lung Cancer Mutation Consortium

Using multiplexed assays of oncogenic drivers in lung cancers to select targeted drugs

Coordinated regulation of protein synthesis and degradation by mTORC1

Mutational Analysis of 472 Urothelial Carcinoma Across Grades and Anatomic Sites

Response and Acquired Resistance to Everolimus in Anaplastic Thyroid Cancer

mTORC1 upregulates B7-H3/CD276 to inhibit antitumor T cells and drive tumor immune evasion

Molecular testing guideline for selection of lung cancer patients for EGFR and ALK tyrosine kinase inhibitors: guideline from the College of American Pathologists, International Association for the Study of Lung Cancer, and Association for Molecular Pathology

Invasive Bladder Cancer: Genomic Insights and Therapeutic Promise

Somatic Mutations Activating the mTOR Pathway in Dorsal Telencephalic Progenitors Cause a Continuum of Cortical Dysplasias

Reversal of learning deficits in a Tsc2 +/− mouse model of tuberous sclerosis

Response of a Neuronal Model of Tuberous Sclerosis to Mammalian Target of Rapamycin (mTOR) Inhibitors: Effects on mTORC1 and Akt Signaling Lead to Improved Survival and Function

Pan-Cancer Molecular Classes Transcending Tumor Lineage Across 32 Cancer Types, Multiple Data Platforms, and over 10,000 Cases

Mammalian target of rapamycin pathway mutations cause hemimegalencephaly and focal cortical dysplasia

Multi-institutional Oncogenic Driver Mutation Analysis in Lung Adenocarcinoma: The Lung Cancer Mutation Consortium Experience

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