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Molecular basis for inhibition of AcrB multidrug efflux pump by novel and powerful pyranopyridine derivatives

Proceedings of the National Academy of Sciences - PNAS, 2016-03, Vol.113 (13), p.3509-3514

2016

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Characterization of a Novel Pyranopyridine Inhibitor of the AcrAB Efflux Pump of Escherichia coli

Antimicrobial Agents and Chemotherapy, 2014-02, Vol.58 (2), p.722-733

2014

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trans-Translation inhibitors bind to a novel site on the ribosome and clear Neisseria gonorrhoeae in vivo

Nature communications, 2021-03, Vol.12 (1), p.1799-12, Article 1799

2021

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Structure–activity relationships of a novel pyranopyridine series of Gram-negative bacterial efflux pump inhibitors

Bioorganic & medicinal chemistry, 2015-05, Vol.23 (9), p.2024-2034

2015

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Unsaturated fatty acid perturbation combats emerging triazole antifungal resistance in the human fungal pathogen Aspergillus fumigatus

mBio, 2024-06, Vol.15 (7), p.e0116624

2024

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Towards Development of Small Molecule Lipid II Inhibitors as Novel Antibiotics

PloS one, 2016-10, Vol.11 (10), p.e0164515-e0164515

2016

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Aryl Rhodanines Specifically Inhibit Staphylococcal and Enterococcal Biofilm Formation

Antimicrobial Agents and Chemotherapy, 2009-10, Vol.53 (10), p.4357-4367

2009

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Luciferase-Based High-Throughput Screen with Aspergillus fumigatus to Identify Antifungal Small Molecules

Methods in molecular biology (Clifton, N.J.), 2023, Vol.2658, p.17

2023

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Optimized pyridazinone nutrient channel inhibitors are potent and specific antimalarial leads

Molecular pharmacology, 2022-09, Vol.102 (3), p.MOLPHARM-AR-2022-000549-182

2022

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Investigating N-arylpyrimidinamine (NAPA) compounds as early-stage inhibitors against human cytomegalovirus

Antiviral research, 2023-01, Vol.209, p.105474-105474, Article 105474

2023

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Static Biofilm Cultures of Gram‐Positive Pathogens Grown in a Microtiter Format Used for Anti‐Biofilm Drug Discovery

Current Protocols in Pharmacology, 2010-09, Vol.50 (1), p.13A.8.1-13A.8.23

2010

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Optimization of a small-molecule Lipid II binder

Bioorganic & medicinal chemistry letters, 2019-07, Vol.29 (14), p.1849-1853

2019

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DNA Targeting as a Likely Mechanism Underlying the Antibacterial Activity of Synthetic Bis-Indole Antibiotics

Antimicrobial agents and chemotherapy, 2016-12, Vol.60 (12), p.7067-7076

2016

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Synthesis and antifungal evaluation of head-to-head and head-to-tail bisamidine compounds

Bioorganic & medicinal chemistry, 2015-09, Vol.23 (17), p.5789-5798

2015

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Discovery of bacterial fatty acid synthase type II inhibitors using a novel cellular bioluminescent reporter assay

Antimicrobial agents and chemotherapy, 2015-09, Vol.59 (9), p.5775-5787

2015

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Detour of prenostodione synthesis towards pyrazolones for antibacterial activity

Bioorganic & medicinal chemistry letters, 2013-06, Vol.23 (11), p.3235-3238

2013

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Structure-activity exploration of a small-molecule Lipid II inhibitor

Drug design, development and therapy, 2015-01, Vol.9 (default), p.2383-2394

2015

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Molecular Insights into Compound-Transporter Interactions: The Case of Inhibitors of Gram-Negative Bacteria Efflux Pumps

Biophysical journal, 2017-02, Vol.112 (3), p.274a-274a

2017

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Design, synthesis and activities of 4/5-acyl-2-aminoimidazolyl analogues of oroidin for biofilm inhibition

MedChemComm, 2013-11, Vol.4 (11), p.1467

2013

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Design, synthesis and activities of 4/5-acyl-2-aminoimidazolyl analogues of oroidin for biofilm inhibitionElectronic supplementary information (ESI) available: Complete experimental procedures are provided, including copies of 1H and 13C NMR spectra of all new compounds and HRMS analysis. X-ray data (CIF) for 2A are also provided. See DOI: 10.1039/c3md00143a

2013-10

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Association of arginine vasopressin levels with outcomes and the effect of V2 blockade in patients hospitalized for heart failure with reduced ejection fraction: insights from the EVEREST trial

Circulation. Heart failure, 2013-01, Vol.6 (1), p.47-52

2013

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Are back supports plus education more effective than education alone in promoting recovery from low back pain? : Results from a randomized clinical trial

Spine (Philadelphia, Pa. 1976), 2007-09, Vol.32 (19), p.2050-2057

2007

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Participation in Occupational Health Longitudinal Studies: Predictors of Missed Visits and Dropouts

Annals of epidemiology, 2007-01, Vol.17 (1), p.9-18

2007

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Molecular basis for inhibition of AcrB multidrug efflux pump by novel and powerful pyranopyridine derivatives

Characterization of a Novel Pyranopyridine Inhibitor of the AcrAB Efflux Pump of Escherichia coli

trans-Translation inhibitors bind to a novel site on the ribosome and clear Neisseria gonorrhoeae in vivo

Structure–activity relationships of a novel pyranopyridine series of Gram-negative bacterial efflux pump inhibitors

Unsaturated fatty acid perturbation combats emerging triazole antifungal resistance in the human fungal pathogen Aspergillus fumigatus

Towards Development of Small Molecule Lipid II Inhibitors as Novel Antibiotics

Aryl Rhodanines Specifically Inhibit Staphylococcal and Enterococcal Biofilm Formation

Luciferase-Based High-Throughput Screen with Aspergillus fumigatus to Identify Antifungal Small Molecules

Optimized pyridazinone nutrient channel inhibitors are potent and specific antimalarial leads

Investigating N-arylpyrimidinamine (NAPA) compounds as early-stage inhibitors against human cytomegalovirus

Static Biofilm Cultures of Gram‐Positive Pathogens Grown in a Microtiter Format Used for Anti‐Biofilm Drug Discovery

Optimization of a small-molecule Lipid II binder

DNA Targeting as a Likely Mechanism Underlying the Antibacterial Activity of Synthetic Bis-Indole Antibiotics

Synthesis and antifungal evaluation of head-to-head and head-to-tail bisamidine compounds

Discovery of bacterial fatty acid synthase type II inhibitors using a novel cellular bioluminescent reporter assay

Detour of prenostodione synthesis towards pyrazolones for antibacterial activity

Structure-activity exploration of a small-molecule Lipid II inhibitor

Molecular Insights into Compound-Transporter Interactions: The Case of Inhibitors of Gram-Negative Bacteria Efflux Pumps

Design, synthesis and activities of 4/5-acyl-2-aminoimidazolyl analogues of oroidin for biofilm inhibition

Association of arginine vasopressin levels with outcomes and the effect of V2 blockade in patients hospitalized for heart failure with reduced ejection fraction: insights from the EVEREST trial

Are back supports plus education more effective than education alone in promoting recovery from low back pain? : Results from a randomized clinical trial

Participation in Occupational Health Longitudinal Studies: Predictors of Missed Visits and Dropouts

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