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Conditional Deletion Of Brain-Derived Neurotrophic Factor in the Postnatal Brain Leads to Obesity and Hyperactivity

Molecular endocrinology (Baltimore, Md.), 2001-10, Vol.15 (10), p.1748-1757

2001

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Genome engineering in rodents – status quo and perspectives

Laboratory animals (London), 2022-02, Vol.56 (1), p.83-87

Kühn, Ralf

2022

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Increasing the efficiency of homology-directed repair for CRISPR-Cas9-induced precise gene editing in mammalian cells

Nature biotechnology, 2015-05, Vol.33 (5), p.543-548

2015

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Development of an intein-mediated split-Cas9 system for gene therapy

Nucleic acids research, 2015-07, Vol.43 (13), p.6450

2015

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Cell-type-specific profiling of brain mitochondria reveals functional and molecular diversity

Nature neuroscience, 2019-10, Vol.22 (10), p.1731-1742

2019

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Control of gene editing by manipulation of DNA repair mechanisms

Mammalian genome, 2017-08, Vol.28 (7-8), p.262-274

2017

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Efficient generation of Rosa26 knock-in mice using CRISPR/Cas9 in C57BL/6 zygotes

BMC biotechnology, 2016-01, Vol.16 (4), p.4, Article 4

2016

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Gene editing in mouse zygotes using the CRISPR/Cas9 system

Methods (San Diego, Calif.), 2017-05, Vol.121-122, p.55-67

2017

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Gene targeting by homologous recombination in mouse zygotes mediated by zinc-finger nucleases

Proceedings of the National Academy of Sciences - PNAS, 2010-08, Vol.107 (34), p.15022-15026

2010

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In vivo dissection of a clustered-CTCF domain boundary reveals developmental principles of regulatory insulation

Nature genetics, 2022-07, Vol.54 (7), p.1026-1036

2022

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Microglia sense neuronal activity via GABA in the early postnatal hippocampus

Cell reports (Cambridge), 2021-12, Vol.37 (13), p.110128-110128, Article 110128

2021

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Pop in, pop out: a novel gene-targeting strategy for use with CRISPR-Cas9

Genome Biology, 2015-11, Vol.16 (1), p.244-244, Article 244

2015

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In vivo CRISPR/Cas9-mediated screen reveals a critical function of TFDP1 and E2F4 transcription factors in hematopoiesis

Leukemia, 2024-09, Vol.38 (9), p.2003-2015

2024

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Efficient CRISPR-mediated mutagenesis in primary immune cells using CrispRGold and a C57BL/6 Cas9 transgenic mouse line

Proceedings of the National Academy of Sciences - PNAS, 2016-11, Vol.113 (44), p.12514-12519

2016

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A deletion containing a CTCF-element in intron 8 of the Bbs7 gene is partially responsible for juvenile obesity in the Berlin Fat Mouse

Mammalian genome, 2022-09, Vol.33 (3), p.465-470

2022

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Mutations in Disordered Regions Can Cause Disease by Creating Dileucine Motifs

Cell, 2018-09, Vol.175 (1), p.239-253.e17

2018

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Lipoprotein Apheresis for Lipoprotein(a)-Associated Cardiovascular Disease: Prospective 5 Years of Follow-Up and Apolipoprotein(a) Characterization

Arteriosclerosis, thrombosis, and vascular biology, 2016-09, Vol.36 (9), p.2019-2027

2016

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IFNγ binding to extracellular matrix prevents fatal systemic toxicity

Nature immunology, 2023-03, Vol.24 (3), p.414-422

2023

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Oscillations of MyoD and Hes1 proteins regulate the maintenance of activated muscle stem cells

Genes & development, 2019-05, Vol.33 (9-10), p.524-535

2019

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Fusion of SpCas9 to E. coli Rec A protein enhances CRISPR-Cas9 mediated gene knockout in mammalian cells

Journal of biotechnology, 2017-04, Vol.247, p.42-49

2017

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CRISPR-Cas9-Mediated ELANE Mutation Correction in Hematopoietic Stem and Progenitor Cells to Treat Severe Congenital Neutropenia

Molecular therapy, 2020-12, Vol.28 (12), p.2621-2634

2020

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Gene editing and clonal isolation of human induced pluripotent stem cells using CRISPR/Cas9

Methods (San Diego, Calif.), 2017-05, Vol.121-122, p.29-44

2017

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Novel human neurodevelopmental and neurodegenerative disease associated with IRF2BPL gene variants-mechanisms and therapeutic avenues

Frontiers in neuroscience, 2024-06, Vol.18, p.1426177

2024

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Direct production of mouse disease models by embryo microinjection of TALENs and oligodeoxynucleotides

Proceedings of the National Academy of Sciences - PNAS, 2013-03, Vol.110 (10), p.3782-3787

2013

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Enhancement of Precise Gene Editing by the Association of Cas9 With Homologous Recombination Factors

Frontiers in genetics, 2019-04, Vol.10, p.365-365

2019

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Conditional Deletion Of Brain-Derived Neurotrophic Factor in the Postnatal Brain Leads to Obesity and Hyperactivity

Genome engineering in rodents – status quo and perspectives

Increasing the efficiency of homology-directed repair for CRISPR-Cas9-induced precise gene editing in mammalian cells

Development of an intein-mediated split-Cas9 system for gene therapy

Cell-type-specific profiling of brain mitochondria reveals functional and molecular diversity

Control of gene editing by manipulation of DNA repair mechanisms

Efficient generation of Rosa26 knock-in mice using CRISPR/Cas9 in C57BL/6 zygotes

Gene editing in mouse zygotes using the CRISPR/Cas9 system

Gene targeting by homologous recombination in mouse zygotes mediated by zinc-finger nucleases

In vivo dissection of a clustered-CTCF domain boundary reveals developmental principles of regulatory insulation

Microglia sense neuronal activity via GABA in the early postnatal hippocampus

Pop in, pop out: a novel gene-targeting strategy for use with CRISPR-Cas9

In vivo CRISPR/Cas9-mediated screen reveals a critical function of TFDP1 and E2F4 transcription factors in hematopoiesis

Efficient CRISPR-mediated mutagenesis in primary immune cells using CrispRGold and a C57BL/6 Cas9 transgenic mouse line

A deletion containing a CTCF-element in intron 8 of the Bbs7 gene is partially responsible for juvenile obesity in the Berlin Fat Mouse

Mutations in Disordered Regions Can Cause Disease by Creating Dileucine Motifs

Lipoprotein Apheresis for Lipoprotein(a)-Associated Cardiovascular Disease: Prospective 5 Years of Follow-Up and Apolipoprotein(a) Characterization

IFNγ binding to extracellular matrix prevents fatal systemic toxicity

Oscillations of MyoD and Hes1 proteins regulate the maintenance of activated muscle stem cells

Fusion of SpCas9 to E. coli Rec A protein enhances CRISPR-Cas9 mediated gene knockout in mammalian cells

CRISPR-Cas9-Mediated ELANE Mutation Correction in Hematopoietic Stem and Progenitor Cells to Treat Severe Congenital Neutropenia

Gene editing and clonal isolation of human induced pluripotent stem cells using CRISPR/Cas9

Novel human neurodevelopmental and neurodegenerative disease associated with IRF2BPL gene variants-mechanisms and therapeutic avenues

Direct production of mouse disease models by embryo microinjection of TALENs and oligodeoxynucleotides

Enhancement of Precise Gene Editing by the Association of Cas9 With Homologous Recombination Factors

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