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Discovery of Vilaprisan (BAY 1002670): A Highly Potent and Selective Progesterone Receptor Modulator Optimized for Gynecologic Therapies

ChemMedChem, 2018-11, Vol.13 (21), p.2271-2280

2018

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Unsteady Aerodynamic Loads on a High-Agility Aircraft due to Wake Vortex Encounter

Journal of aircraft, 2014-09, Vol.51 (5), p.1511-1521

2014

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Total Synthesis and Antitumor Activity of ZK-EPO: The First Fully Synthetic Epothilone in Clinical Development

Angewandte Chemie International Edition, 2006-12, Vol.45 (47), p.7942-7948

2006

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Sagopilone crosses the blood-brain barrier in vivo to inhibit brain tumor growth and metastases

Neuro-oncology (Charlottesville, Va.), 2009-04, Vol.11 (2), p.158-166

2009

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Molecular mode of action and role of TP53 in the sensitivity to the novel epothilone sagopilone (ZK-EPO) in A549 non-small cell lung cancer cells

PloS one, 2011-04, Vol.6 (4), p.e19273-e19273

2011

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Sagopilone Inhibits Breast Cancer Bone Metastasis and Bone Destruction Due to Simultaneous Inhibition of Both Tumor Growth and Bone Resorption

Clinical cancer research, 2009-06, Vol.15 (11), p.3751-3759

2009

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Differences and Similarities of Epothilones

Current cancer therapy reviews, 2011-02, Vol.7 (1), p.10-36

2011

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Asymmetric Total Synthesis of the Epothilone Sagopilone - From Research to Development

Synlett, 2012-06, Vol.23 (9), p.1291-1299

2012

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Novel Mps1 Kinase Inhibitors with Potent Antitumor Activity

Molecular cancer therapeutics, 2016-04, Vol.15 (4), p.583-592

2016

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Treating Cancer by Spindle Assembly Checkpoint Abrogation: Discovery of Two Clinical Candidates, BAY 1161909 and BAY 1217389, Targeting MPS1 Kinase

Journal of medicinal chemistry, 2020-08, Vol.63 (15), p.8025-8042

2020

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Integrated Experimental-Numerical Analysis of High-Agility Aircraft Wake Vortex Evolution

Journal of aircraft, 2011-11, Vol.48 (6), p.2050-2058

2011

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Silicon-Based Building Blocks for One-Step ¹⁸F-Radiolabeling of Peptides for PET Imaging

Angewandte Chemie (International ed.), 2008, Vol.47 (26), p.4922-4925

2008

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Biocatalysis at Work: Applications in the Development of Sagopilone

ChemMedChem, 2015-07, Vol.10 (7), p.1240-1248

2015

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Comparative Profiling of the Novel Epothilone, Sagopilone, in Xenografts Derived from Primary Non-Small Cell Lung Cancer

Clinical cancer research, 2010-03, Vol.16 (5), p.1452-1465

2010

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Front Cover: Discovery of Vilaprisan (BAY 1002670): A Highly Potent and Selective Progesterone Receptor Modulator Optimized for Gynecologic Therapies (ChemMedChem 21/2018)

ChemMedChem, 2018-11, Vol.13 (21), p.2250-2250

2018

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Sagopilone (ZK-EPO): from a natural product to a fully synthetic clinical development candidate

Expert opinion on investigational drugs, 2008-11, Vol.17 (11), p.1735-1748

2008

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Improved Cellular Pharmacokinetics and Pharmacodynamics Underlie the Wide Anticancer Activity of Sagopilone

Cancer research (Chicago, Ill.), 2008-07, Vol.68 (13), p.5301-5308

2008

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Abstract 3090: Novel Mps1 kinase inhibitors with potent anti-tumor activity

Cancer research (Chicago, Ill.), 2015-08, Vol.75 (15_Supplement), p.3090-3090

2015

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Signaling-inactive epidermal growth factor receptor/ligand complexes in intact carcinoma cells by quinazoline tyrosine kinase inhibitors

Cancer research (Chicago, Ill.), 2001-08, Vol.61 (15), p.5790-5795

2001

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Amine-Induced Decomposition of Perfluoroalkanesulfonyl Fluorides

Synthesis (Stuttgart), 2008-04, Vol.2008 (8), p.1175-1178

2008

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Efficient Chiral Pool Synthesis of the C1-C6 Fragment of Epothilones

Synthesis (Stuttgart), 2005, Vol.2005 (2), p.301-305

2005

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Organofluorosilanes as Model Compounds for 18 F‐Labeled Silicon‐Based PET Tracers and their Hydrolytic Stability: Experimental Data and Theoretical Calculations (PET=Positron Emission Tomography)

Chemistry : a European journal, 2009-04, Vol.15 (15), p.3736-3743

2009

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SAGOPILONE, A NOVEL EPOTHILONE, INHIBITS TUMOR CELL GROWTH IN PRECLINICAL MODELS OF UROLOGICAL CANCER

The Journal of urology, 2008, Vol.179 (4), p.479-479

2008

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Organofluorosilanes as Model Compounds for 18F-Labeled Silicon-Based PET Tracers and their Hydrolytic Stability: Experimental Data and Theoretical Calculations (PET=Positron Emission Tomography)

Chemistry : a European journal, 2009-04, Vol.15 (15), p.3736-3743

2009

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Sagopilone (ZK-EPO) inhibits bone destruction and tumor burden more efficiently than paclitaxel in a mouse model of established breast cancer bone metastasis

Bone (New York, N.Y.), 2008-03, Vol.42, p.S108-S108

2008

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Discovery of Vilaprisan (BAY 1002670): A Highly Potent and Selective Progesterone Receptor Modulator Optimized for Gynecologic Therapies

Unsteady Aerodynamic Loads on a High-Agility Aircraft due to Wake Vortex Encounter

Total Synthesis and Antitumor Activity of ZK-EPO: The First Fully Synthetic Epothilone in Clinical Development

Sagopilone crosses the blood-brain barrier in vivo to inhibit brain tumor growth and metastases

Molecular mode of action and role of TP53 in the sensitivity to the novel epothilone sagopilone (ZK-EPO) in A549 non-small cell lung cancer cells

Sagopilone Inhibits Breast Cancer Bone Metastasis and Bone Destruction Due to Simultaneous Inhibition of Both Tumor Growth and Bone Resorption

Differences and Similarities of Epothilones

Asymmetric Total Synthesis of the Epothilone Sagopilone - From Research to Development

Novel Mps1 Kinase Inhibitors with Potent Antitumor Activity

Treating Cancer by Spindle Assembly Checkpoint Abrogation: Discovery of Two Clinical Candidates, BAY 1161909 and BAY 1217389, Targeting MPS1 Kinase

Integrated Experimental-Numerical Analysis of High-Agility Aircraft Wake Vortex Evolution

Silicon-Based Building Blocks for One-Step ¹⁸F-Radiolabeling of Peptides for PET Imaging

Biocatalysis at Work: Applications in the Development of Sagopilone

Comparative Profiling of the Novel Epothilone, Sagopilone, in Xenografts Derived from Primary Non-Small Cell Lung Cancer

Front Cover: Discovery of Vilaprisan (BAY 1002670): A Highly Potent and Selective Progesterone Receptor Modulator Optimized for Gynecologic Therapies (ChemMedChem 21/2018)

Sagopilone (ZK-EPO): from a natural product to a fully synthetic clinical development candidate

Improved Cellular Pharmacokinetics and Pharmacodynamics Underlie the Wide Anticancer Activity of Sagopilone

Abstract 3090: Novel Mps1 kinase inhibitors with potent anti-tumor activity

Signaling-inactive epidermal growth factor receptor/ligand complexes in intact carcinoma cells by quinazoline tyrosine kinase inhibitors

Amine-Induced Decomposition of Perfluoroalkanesulfonyl Fluorides

Efficient Chiral Pool Synthesis of the C1-C6 Fragment of Epothilones

Organofluorosilanes as Model Compounds for 18 F‐Labeled Silicon‐Based PET Tracers and their Hydrolytic Stability: Experimental Data and Theoretical Calculations (PET=Positron Emission Tomography)

SAGOPILONE, A NOVEL EPOTHILONE, INHIBITS TUMOR CELL GROWTH IN PRECLINICAL MODELS OF UROLOGICAL CANCER

Organofluorosilanes as Model Compounds for 18F-Labeled Silicon-Based PET Tracers and their Hydrolytic Stability: Experimental Data and Theoretical Calculations (PET=Positron Emission Tomography)

Sagopilone (ZK-EPO) inhibits bone destruction and tumor burden more efficiently than paclitaxel in a mouse model of established breast cancer bone metastasis

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