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IQ consortium perspective: complementary LBA and LC–MS in protein therapeutics bioanalysis and biotransformation assessment

Bioanalysis, 2020-02, Vol.12 (4), p.257-270

2020

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Mapping intact protein isoforms in discovery mode using top―down proteomics

Nature (London), 2011-10, Vol.480 (7376), p.254-258

2011

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Protein LC-MS Tools for the Next Generation of Biotherapeutic Analyses from Preclinical and Clinical Serum

Journal of the American Society for Mass Spectrometry, 2023-09, Vol.34 (9), p.1837-1846

2023

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Quantitative measurement of intact alpha-synuclein proteoforms from post-mortem control and Parkinson's disease brain tissue by intact protein mass spectrometry

Scientific reports, 2014-07, Vol.4 (1), p.5797-5797, Article 5797

2014

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A Robust Two-Dimensional Separation for Top-Down Tandem Mass Spectrometry of the Low-Mass Proteome

Journal of the American Society for Mass Spectrometry, 2009-12, Vol.20 (12), p.2183-2191

2009

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Determination of label efficiency and label degree of critical reagents by LC-MS and native MS

Analytical biochemistry, 2023-03, Vol.664, p.115033-115033, Article 115033

2023

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Intact mass detection, interpretation, and visualization to automate Top-Down proteomics on a large scale

Proteomics (Weinheim), 2010-10, Vol.10 (20), p.3589-3597

2010

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Intact Protein Mass Spectrometry for Therapeutic Protein Quantitation, Pharmacokinetics, and Biotransformation in Preclinical and Clinical Studies: An Industry Perspective

Journal of the American Society for Mass Spectrometry, 2021-08, Vol.32 (8), p.1886-1900

2021

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Top-Down Characterization and Intact Mass Quantitation of a Monoclonal Antibody Drug from Serum by Use of a Quadrupole TOF MS System Equipped with Electron-Activated Dissociation

Journal of the American Society for Mass Spectrometry, 2023-01, Vol.34 (1), p.17-26

2023

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Review of approaches and examples for monitoring biotransformation in protein and peptide therapeutics by MS

Bioanalysis, 2018-11, Vol.10 (22), p.1877-1890

2018

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An antibody-free platform for multiplexed, sensitive quantification of protein biomarkers in complex biomatrices

Journal of Chromatography A, 2022-08, Vol.1676, p.463261, Article 463261

2022

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Separation techniques for intact antibody analysis by mass spectrometry

Journal of liquid chromatography & related technologies, 2022-12, Vol.45 (17-20), p.271-283

2022

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Native high-resolution mass spectrometry analysis of noncovalent protein complexes up to 450 kDa

Bioanalysis, 2020-10, Vol.12 (19), p.1353-1362

2020

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Drug monitoring by volumetric absorptive microsampling: method development considerations to mitigate hematocrit effects

Bioanalysis, 2018-02, Vol.10 (4), p.241-255

2018

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Biotherapeutic Antibody Subunit LC-MS and Peptide Mapping LC-MS Measurements to Study Possible Biotransformation and Critical Quality Attributes In Vivo

Journal of pharmaceutical sciences, 2019-04, Vol.108 (4), p.1415-1422

2019

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Toward best practices in data processing and analysis for intact biotherapeutics by MS in quantitative bioanalysis

Bioanalysis, 2017-12, Vol.9 (23), p.1883-1893

2017

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A whole-molecule immunocapture LC-MS approach for the in vivo quantitation of biotherapeutics

Bioanalysis, 2016-10, Vol.8 (20), p.2103-2114

2016

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Application of high-resolution MS for development of peptide and large-molecule drug candidates

Bioanalysis, 2016-02, Vol.8 (3), p.169-177

2016

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Robust Analysis of the Yeast Proteome under 50 kDa by Molecular-Mass-Based Fractionation and Top-Down Mass Spectrometry

Analytical chemistry (Washington), 2012-01, Vol.84 (1), p.209-215

2012

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Size-Sorting Combined with Improved Nanocapillary Liquid Chromatography−Mass Spectrometry for Identification of Intact Proteins up to 80 kDa

Analytical chemistry (Washington), 2010-02, Vol.82 (4), p.1234-1244

2010

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2021 White Paper on Recent Issues in Bioanalysis: Mass Spec of Proteins, Extracellular Vesicles, CRISPR, Chiral Assays, Oligos; Nanomedicines Bioanalysis; ICH M10 Section 7.1; Non-Liquid & Rare Matrices; Regulatory Inputs

Bioanalysis, 2022-05, Vol.14 (9), p.505-580

2022

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Intact mAb LC–MS for drug concentration from pre-clinical studies: bioanalytical method performance and in-life samples

Bioanalysis, 2020-10, Vol.12 (19), p.1389-1403

2020

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A new era for proteomics

Bioanalysis, 2019-10, Vol.11 (19), p.1731-1735

2019

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The emerging process of Top Down mass spectrometry for protein analysis: biomarkers, protein-therapeutics, and achieving high throughput

Molecular bioSystems, 2010-09, Vol.6 (9), p.1532-1539

2010

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Nano-LC FTICR Tandem Mass Spectrometry for Top-Down Proteomics: Routine Baseline Unit Mass Resolution of Whole Cell Lysate Proteins up to 72 kDa

Analytical chemistry (Washington), 2012-03, Vol.84 (5), p.2111-2117

2012

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IQ consortium perspective: complementary LBA and LC–MS in protein therapeutics bioanalysis and biotransformation assessment

Mapping intact protein isoforms in discovery mode using top―down proteomics

Protein LC-MS Tools for the Next Generation of Biotherapeutic Analyses from Preclinical and Clinical Serum

Quantitative measurement of intact alpha-synuclein proteoforms from post-mortem control and Parkinson's disease brain tissue by intact protein mass spectrometry

A Robust Two-Dimensional Separation for Top-Down Tandem Mass Spectrometry of the Low-Mass Proteome

Determination of label efficiency and label degree of critical reagents by LC-MS and native MS

Intact mass detection, interpretation, and visualization to automate Top-Down proteomics on a large scale

Intact Protein Mass Spectrometry for Therapeutic Protein Quantitation, Pharmacokinetics, and Biotransformation in Preclinical and Clinical Studies: An Industry Perspective

Top-Down Characterization and Intact Mass Quantitation of a Monoclonal Antibody Drug from Serum by Use of a Quadrupole TOF MS System Equipped with Electron-Activated Dissociation

Review of approaches and examples for monitoring biotransformation in protein and peptide therapeutics by MS

An antibody-free platform for multiplexed, sensitive quantification of protein biomarkers in complex biomatrices

Separation techniques for intact antibody analysis by mass spectrometry

Native high-resolution mass spectrometry analysis of noncovalent protein complexes up to 450 kDa

Drug monitoring by volumetric absorptive microsampling: method development considerations to mitigate hematocrit effects

Biotherapeutic Antibody Subunit LC-MS and Peptide Mapping LC-MS Measurements to Study Possible Biotransformation and Critical Quality Attributes In Vivo

Toward best practices in data processing and analysis for intact biotherapeutics by MS in quantitative bioanalysis

A whole-molecule immunocapture LC-MS approach for the in vivo quantitation of biotherapeutics

Application of high-resolution MS for development of peptide and large-molecule drug candidates

Robust Analysis of the Yeast Proteome under 50 kDa by Molecular-Mass-Based Fractionation and Top-Down Mass Spectrometry

Size-Sorting Combined with Improved Nanocapillary Liquid Chromatography−Mass Spectrometry for Identification of Intact Proteins up to 80 kDa

2021 White Paper on Recent Issues in Bioanalysis: Mass Spec of Proteins, Extracellular Vesicles, CRISPR, Chiral Assays, Oligos; Nanomedicines Bioanalysis; ICH M10 Section 7.1; Non-Liquid & Rare Matrices; Regulatory Inputs

Intact mAb LC–MS for drug concentration from pre-clinical studies: bioanalytical method performance and in-life samples

A new era for proteomics

The emerging process of Top Down mass spectrometry for protein analysis: biomarkers, protein-therapeutics, and achieving high throughput

Nano-LC FTICR Tandem Mass Spectrometry for Top-Down Proteomics: Routine Baseline Unit Mass Resolution of Whole Cell Lysate Proteins up to 72 kDa

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