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Potent and Selective Inhibitors of MTH1 Probe Its Role in Cancer Cell Survival

Journal of medicinal chemistry, 2016-03, Vol.59 (6), p.2346-2361

2016

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Successful generation of structural information for fragment-based drug discovery

Drug discovery today, 2015-09, Vol.20 (9), p.1104-1111

2015

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Machine learning/molecular dynamic protein structure prediction approach to investigate the protein conformational ensemble

Scientific reports, 2022-06, Vol.12 (1), p.10018-10018, Article 10018

2022

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Discovery of Second Generation Reversible Covalent DPP1 Inhibitors Leading to an Oxazepane Amidoacetonitrile Based Clinical Candidate (AZD7986)

Journal of medicinal chemistry, 2016-10, Vol.59 (20), p.9457-9472

2016

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X‑ray Characterization and Structure-Based Optimization of Striatal-Enriched Protein Tyrosine Phosphatase Inhibitors

Journal of medicinal chemistry, 2017-11, Vol.60 (22), p.9299-9319

2017

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Fragment-Based Discovery of Novel Allosteric MEK1 Binders

ACS medicinal chemistry letters, 2021-02, Vol.12 (2), p.302-308

2021

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Combining structural and coevolution information to unveil allosteric sites

Chemical science (Cambridge), 2023-06, Vol.14 (25), p.757-767

2023

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DPP1 Inhibitors: Exploring the Role of Water in the S2 Pocket of DPP1 with Substituted Pyrrolidines

ACS medicinal chemistry letters, 2019-08, Vol.10 (8), p.1222-1227

2019

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The manifold of vitamin B6 dependent enzymes

Structure (London), 2000, Vol.8 (1), p.R1-R6

2000

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An Angle on MK2 Inhibition—Optimization and Evaluation of Prevention of Activation Inhibitors

ChemMedChem, 2019-10, Vol.14 (19), p.1701-1709

2019

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Discovery and optimization of cyclohexane-1,4-diamines as allosteric MALT1 inhibitors

European journal of medicinal chemistry, 2022-01, Vol.227, p.113925-113925, Article 113925

2022

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A Homogeneous in Vitro Functional Assay for Estrogen Receptors: Coactivator Recruitment

Molecular endocrinology (Baltimore, Md.), 2003-03, Vol.17 (3), p.346-355

2003

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The structures of salt-inducible kinase 3 in complex with inhibitors reveal determinants for binding and selectivity

The Journal of biological chemistry, 2024-05, Vol.300 (5), p.107201-107201, Article 107201

2024

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Crystal structure of diaminopelargonic acid synthase: evolutionary relationships between pyridoxal-5′-phosphate-dependent enzymes

Journal of molecular biology, 1999-08, Vol.291 (4), p.857-876

1999

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The discovery of novel, potent and highly selective inhibitors of inducible nitric oxide synthase (iNOS)

Bioorganic & medicinal chemistry letters, 2011-04, Vol.21 (8), p.2468-2471

2011

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A cell-active cyclic peptide targeting the Nrf2/Keap1 protein-protein interaction

Chemical science (Cambridge), 2023-10, Vol.14 (39), p.18-185

2023

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Design of inhibitors of Helicobacter pylori glutamate racemase as selective antibacterial agents: Incorporation of imidazoles onto a core pyrazolopyrimidinedione scaffold to improve bioavailabilty

Bioorganic & medicinal chemistry letters, 2012-09, Vol.22 (17), p.5600-5607

2012

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Snapshot of a Phosphorylated Substrate Intermediate by Kinetic Crystallography

Proceedings of the National Academy of Sciences - PNAS, 1998-05, Vol.95 (10), p.5495-5500

1998

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Front Cover: An Angle on MK2 Inhibition—Optimization and Evaluation of Prevention of Activation Inhibitors (ChemMedChem 19/2019)

ChemMedChem, 2019-10, Vol.14 (19), p.1692-1692

2019

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Crystal structure of two quaternary complexes of dethiobiotin synthetase, enzyme‐MgADP‐AlF3‐diaminopelargonic acid and enzyme‐MgADP‐dethiobiotin‐phosphate; implications for catalysis

Protein science, 1998-12, Vol.7 (12), p.2560-2566

1998

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Structure of dethiobiotin synthetase at 0.97 Å resolution

Acta crystallographica. Section D, Biological crystallography., 1999-03, Vol.55 (3), p.610-624

1999

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Crystal structure of two quaternary complexes of dethiobiotin synthetase, enzyme‐MgADP‐AlF 3 ‐diaminopelargonic acid and enzyme‐MgADP‐dethiobiotin‐phosphate; implications for catalysis

Protein science, 1998-12, Vol.7 (12), p.2560-2566

1998

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Purification and preliminary X-ray crystallographic studies of recombinant 7,8-diaminopelargonic acid synthase from Escherichia coli

Acta crystallographica. Section D, Biological crystallography., 1998-11, Vol.54 (6-2), p.1397-1398

1998

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Potent and Selective Inhibitors of MTH1 Probe Its Role in Cancer Cell Survival

Successful generation of structural information for fragment-based drug discovery

Machine learning/molecular dynamic protein structure prediction approach to investigate the protein conformational ensemble

Discovery of Second Generation Reversible Covalent DPP1 Inhibitors Leading to an Oxazepane Amidoacetonitrile Based Clinical Candidate (AZD7986)

X‑ray Characterization and Structure-Based Optimization of Striatal-Enriched Protein Tyrosine Phosphatase Inhibitors

Fragment-Based Discovery of Novel Allosteric MEK1 Binders

Combining structural and coevolution information to unveil allosteric sites

DPP1 Inhibitors: Exploring the Role of Water in the S2 Pocket of DPP1 with Substituted Pyrrolidines

The manifold of vitamin B6 dependent enzymes

A novel IgE-neutralizing antibody for the treatment of severe uncontrolled asthma

An Angle on MK2 Inhibition—Optimization and Evaluation of Prevention of Activation Inhibitors

Discovery and optimization of cyclohexane-1,4-diamines as allosteric MALT1 inhibitors

Discovery of the Oral Leukotriene C4 Synthase Inhibitor (1S,2S)‑2-({5-[(5-Chloro-2,4-difluorophenyl)(2-fluoro-2-methylpropyl)amino]-3-methoxypyrazin-2-yl}carbonyl)cyclopropanecarboxylic Acid (AZD9898) as a New Treatment for Asthma

A Homogeneous in Vitro Functional Assay for Estrogen Receptors: Coactivator Recruitment

The structures of salt-inducible kinase 3 in complex with inhibitors reveal determinants for binding and selectivity

Crystal structure of diaminopelargonic acid synthase: evolutionary relationships between pyridoxal-5′-phosphate-dependent enzymes

The discovery of novel, potent and highly selective inhibitors of inducible nitric oxide synthase (iNOS)

A cell-active cyclic peptide targeting the Nrf2/Keap1 protein-protein interaction

Design of inhibitors of Helicobacter pylori glutamate racemase as selective antibacterial agents: Incorporation of imidazoles onto a core pyrazolopyrimidinedione scaffold to improve bioavailabilty

Snapshot of a Phosphorylated Substrate Intermediate by Kinetic Crystallography

Front Cover: An Angle on MK2 Inhibition—Optimization and Evaluation of Prevention of Activation Inhibitors (ChemMedChem 19/2019)

Crystal structure of two quaternary complexes of dethiobiotin synthetase, enzyme‐MgADP‐AlF3‐diaminopelargonic acid and enzyme‐MgADP‐dethiobiotin‐phosphate; implications for catalysis

Structure of dethiobiotin synthetase at 0.97 Å resolution

Crystal structure of two quaternary complexes of dethiobiotin synthetase, enzyme‐MgADP‐AlF 3 ‐diaminopelargonic acid and enzyme‐MgADP‐dethiobiotin‐phosphate; implications for catalysis

Purification and preliminary X-ray crystallographic studies of recombinant 7,8-diaminopelargonic acid synthase from Escherichia coli

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