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Development of a potent and selective chemical probe for the pleiotropic kinase CK2

Cell chemical biology, 2021-04, Vol.28 (4), p.546-558.e10

2021

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Quantifying CDK inhibitor selectivity in live cells

Nature communications, 2020-06, Vol.11 (1), p.2743-2743, Article 2743

2020

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Towards the Development of an In vivo Chemical Probe for Cyclin G Associated Kinase (GAK)

Molecules (Basel, Switzerland), 2019-11, Vol.24 (22), p.4016

2019

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Noninvasive optical and nuclear imaging of Staphylococcus-specific infection with a human monoclonal antibody-based probe

Virulence, 2018-01, Vol.9 (1), p.262-272

2018

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Predilection for developing a hematogenous orthopaedic implant-associated infection in older versus younger mice

Journal of orthopaedic surgery and research, 2021-09, Vol.16 (1), p.556-556, Article 556

2021

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Mild, Pd-catalyzed stannylation of radioiodination targets

Bioorganic & medicinal chemistry letters, 2015-04, Vol.25 (8), p.1761-1764

2015

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Illuminating the understudied GPCR-ome

Drug discovery today, 2024-03, Vol.29 (3), p.103848-103848, Article 103848

2024

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Identification of Pyrimidine-Based Lead Compounds for Understudied Kinases Implicated in Driving Neurodegeneration

Journal of medicinal chemistry, 2022-01, Vol.65 (2), p.1313-1328

2022

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Non-canonical role of Hippo tumor suppressor serine/threonine kinase 3 STK3 in prostate cancer

Molecular therapy, 2022-01, Vol.30 (1), p.485-500

2022

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A Chemical Probe for Dark Kinase STK17B Derives Its Potency and High Selectivity through a Unique P‑Loop Conformation

Journal of medicinal chemistry, 2020-12, Vol.63 (23), p.14626-14646

2020

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Design, Synthesis, and Characterization of [18F]mG2P026 as a High-Contrast PET Imaging Ligand for Metabotropic Glutamate Receptor 2

Journal of medicinal chemistry, 2022-07, Vol.65 (14), p.9939-9954

2022

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Synthesis and Characterization of 5‑(2-Fluoro-4‑[11C]methoxyphenyl)-2,2-dimethyl-3,4-dihydro‑2H‑pyrano[2,3‑b]pyridine-7-carboxamide as a PET Imaging Ligand for Metabotropic Glutamate Receptor 2

Journal of medicinal chemistry, 2022-02, Vol.65 (3), p.2593-2609

2022

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Virtual Screening of a Chemically Diverse “Superscaffold” Library Enables Ligand Discovery for a Key GPCR Target

ACS chemical biology, 2024-04, Vol.19 (4), p.866-874

2024

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Synthesis and Characterization of 5-(2-Fluoro-4-[ 11 C]methoxyphenyl)-2,2-dimethyl-3,4-dihydro-2 H -pyrano[2,3- b ]pyridine-7-carboxamide as a PET Imaging Ligand for Metabotropic Glutamate Receptor 2

Journal of medicinal chemistry, 2022-02, Vol.65 (3), p.2593-2609

2022

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Fatty acid oxidation by the osteoblast is required for normal bone acquisition in a sex- and diet-dependent manner

JCI insight, 2017-08, Vol.2 (16)

2017

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SGC-AAK1-1: A Chemical Probe Targeting AAK1 and BMP2K

ACS medicinal chemistry letters, 2020-03, Vol.11 (3), p.340-345

2020

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Towards a RIOK2 chemical probe: cellular potency improvement of a selective 2-(acylamino)pyridine series

RSC medicinal chemistry, 2021-01, Vol.12 (1), p.129-136

2021

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Molecularly specific detection of bacterial lipoteichoic acid for diagnosis of prosthetic joint infection of the bone

Bone Research, 2018-04, Vol.6 (1), p.13-8, Article 13

2018

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Temozolomide-induced guanine mutations create exploitable vulnerabilities of guanine-rich DNA and RNA regions in drug-resistant gliomas

Science advances, 2022-06, Vol.8 (25), p.eabn3471

2022

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Mouse model of Gram-negative prosthetic joint infection reveals therapeutic targets

JCI insight, 2018-09, Vol.3 (17)

2018

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Sandmeyer reaction repurposed for the site-selective, non-oxidizing radioiodination of fully-deprotected peptides: Studies on the endogenous opioid peptide α-neoendorphin

Bioorganic & medicinal chemistry letters, 2013-08, Vol.23 (15), p.4347-4350

2013

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Abstract 5808: Examination of clinically relevant inhibitor selectivity in live cells across the CDK family

Cancer research (Chicago, Ill.), 2020-08, Vol.80 (16_Supplement), p.5808-5808

2020

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Synthesis and Characterization of 5-(2-Fluoro-4-11Cmethoxyphenyl)-2,2-dimethyl-3,4-dihydro-2H-pyrano2,3-bpyridine-7-carboxamide as a PET Imaging Ligand for Metabotropic Glutamate Receptor 2

Journal of medicinal chemistry, 2022-02, Vol.65 (3), p.2593

2022

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Towards a RIOK2 chemical probe: cellular potency improvement of a selective 2-(acylamino)pyridine seriesElectronic supplementary information (ESI) available: Figures that summarize previously reported data, biological assay methods and curves, and spectral characterization data. See DOI: 10.1039/d0md00292e

2021-02

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Exploration of novel radioiodine‐labeling techniques for opioid peptides

The FASEB journal, 2010-04, Vol.24 (S1), p.581.1-581.1

2010

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Development of a potent and selective chemical probe for the pleiotropic kinase CK2

Quantifying CDK inhibitor selectivity in live cells

Towards the Development of an In vivo Chemical Probe for Cyclin G Associated Kinase (GAK)

Noninvasive optical and nuclear imaging of Staphylococcus-specific infection with a human monoclonal antibody-based probe

Predilection for developing a hematogenous orthopaedic implant-associated infection in older versus younger mice

Mild, Pd-catalyzed stannylation of radioiodination targets

Illuminating the understudied GPCR-ome

Identification of Pyrimidine-Based Lead Compounds for Understudied Kinases Implicated in Driving Neurodegeneration

Non-canonical role of Hippo tumor suppressor serine/threonine kinase 3 STK3 in prostate cancer

A Chemical Probe for Dark Kinase STK17B Derives Its Potency and High Selectivity through a Unique P‑Loop Conformation

Design, Synthesis, and Characterization of [18F]mG2P026 as a High-Contrast PET Imaging Ligand for Metabotropic Glutamate Receptor 2

Synthesis and Characterization of 5‑(2-Fluoro-4‑[11C]methoxyphenyl)-2,2-dimethyl-3,4-dihydro‑2H‑pyrano[2,3‑b]pyridine-7-carboxamide as a PET Imaging Ligand for Metabotropic Glutamate Receptor 2

Virtual Screening of a Chemically Diverse “Superscaffold” Library Enables Ligand Discovery for a Key GPCR Target

Synthesis and Characterization of 5-(2-Fluoro-4-[ 11 C]methoxyphenyl)-2,2-dimethyl-3,4-dihydro-2 H -pyrano[2,3- b ]pyridine-7-carboxamide as a PET Imaging Ligand for Metabotropic Glutamate Receptor 2

Fatty acid oxidation by the osteoblast is required for normal bone acquisition in a sex- and diet-dependent manner

SGC-AAK1-1: A Chemical Probe Targeting AAK1 and BMP2K

Towards a RIOK2 chemical probe: cellular potency improvement of a selective 2-(acylamino)pyridine series

Molecularly specific detection of bacterial lipoteichoic acid for diagnosis of prosthetic joint infection of the bone

Temozolomide-induced guanine mutations create exploitable vulnerabilities of guanine-rich DNA and RNA regions in drug-resistant gliomas

Mouse model of Gram-negative prosthetic joint infection reveals therapeutic targets

Sandmeyer reaction repurposed for the site-selective, non-oxidizing radioiodination of fully-deprotected peptides: Studies on the endogenous opioid peptide α-neoendorphin

Abstract 5808: Examination of clinically relevant inhibitor selectivity in live cells across the CDK family

Synthesis and Characterization of 5-(2-Fluoro-4-11Cmethoxyphenyl)-2,2-dimethyl-3,4-dihydro-2H-pyrano2,3-bpyridine-7-carboxamide as a PET Imaging Ligand for Metabotropic Glutamate Receptor 2

Exploration of novel radioiodine‐labeling techniques for opioid peptides

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