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A Guide to Rational Dosing of Monoclonal Antibodies

Clinical pharmacokinetics, 2012-02, Vol.51 (2), p.119-135

2012

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Characterization of the long-term pharmacokinetics of bevacizumab following last dose in patients with resected stage II and III carcinoma of the colon

Cancer chemotherapy and pharmacology, 2013-03, Vol.71 (3), p.575-580

2013

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Preclinical pharmacokinetics of MEHD7945A, a novel EGFR/HER3 dual-action antibody, and prediction of its human pharmacokinetics and efficacious clinical dose

Cancer chemotherapy and pharmacology, 2012-04, Vol.69 (4), p.1063-1069

2012

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Population pharmacokinetic and pharmacodynamic modeling of MNRP1685A in cynomolgus monkeys using two-target quasi-steady-state (QSS) model

Journal of pharmacokinetics and pharmacodynamics, 2012-04, Vol.39 (2), p.217-226

2012

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Population pharmacokinetic analysis from phase I and phase II studies of the humanized monovalent antibody, onartuzumab (MetMAb), in patients with advanced solid tumors

Journal of clinical pharmacology, 2013-11, Vol.53 (11), p.1103-1111

2013

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Model‐Based Discovery and Development of Biopharmaceuticals: A Case Study of Mavrilimumab

CPT: pharmacometrics and systems pharmacology, 2018-01, Vol.7 (1), p.5-15

2018

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Anti-Neuropilin-1 (MNRP1685A): Unexpected Pharmacokinetic Differences Across Species, from Preclinical Models to Humans

Pharmaceutical research, 2012-09, Vol.29 (9), p.2512-2521

2012

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Preclinical pharmacokinetics of MFGR1877A, a human monoclonal antibody to FGFR3, and prediction of its efficacious clinical dose for the treatment of t(4;14)-positive multiple myeloma

Cancer chemotherapy and pharmacology, 2012-04, Vol.69 (4), p.1071-1078

2012

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Anti-Neuropilin-I (MNRP1685A): Unexpected Pharmacokinetic Differences Across Species, from Preclinical Models to Humans

Pharmaceutical research, 2012, Vol.29 (9), p.2512-2521

2012

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Human pharmacokinetic (PK) characterization of the novel dual-action anti-HER3/EGFR antibody MEHD7945A (MEHD) in patients with refractory/recurrent epithelial tumors

Journal of clinical oncology, 2012-05, Vol.30 (15_suppl), p.2567-2567

2012

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Chapter 30 - Nonclinical drug development

Atkinson's Principles of Clinical Pharmacology, 2022, p.573-588

Fourth Edition, 2022

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Nonclinical drug development

Atkinson's Principles of Clinical Pharmacology, 2021

2021

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Perceived evidence use: Measurement and construct validation of managerial evidence use as perceived by subordinates

PloS one, 2022-04, Vol.17 (4), p.e0266894-e0266894

2022

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Selection-free genome editing of the sickle mutation in human adult hematopoietic stem/progenitor cells

Science translational medicine, 2016-10, Vol.8 (360), p.360ra134

2016

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Superresolution imaging of Drosophila tissues using expansion microscopy

Molecular biology of the cell, 2018-06, Vol.29 (12), p.1413-1421

2018

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Single-cell analysis reveals fibroblast heterogeneity and myeloid-derived adipocyte progenitors in murine skin wounds

Nature communications, 2019-02, Vol.10 (1), p.650-650, Article 650

2019

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Preservation Methods Differ in Fecal Microbiome Stability, Affecting Suitability for Field Studies

mSystems, 2016-05, Vol.1 (3)

2016

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RNF7 Induces Skeletal Muscle Cell Apoptosis and Arrests Cell Autophagy via Upregulation of THBS1 and Inactivation of the PI3K/Akt Signaling Pathway in a Rat Sepsis Model

Infection and immunity, 2023-04, Vol.91 (4), p.e0053522-e0053522

2023

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Unique features in the intracellular transport of typhoid toxin revealed by a genome-wide screen

PLoS pathogens, 2019-04, Vol.15 (4), p.e1007704-e1007704

2019

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Immature dengue virus is infectious in human immature dendritic cells via interaction with the receptor molecule DC-SIGN

PloS one, 2014-06, Vol.9 (6), p.e98785-e98785

2014

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Analysis of Key Factors Affecting the Coke Pushing Stability of Coke Pusher

Shock and vibration, 2022-01, Vol.2022, p.1-7

2022

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Maternal folic acid supplementation modulates DNA methylation and gene expression in the rat offspring in a gestation period-dependent and organ-specific manner

The Journal of nutritional biochemistry, 2016-07, Vol.33, p.103-110

2016

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Microenvironments in tuberculous granulomas are delineated by distinct populations of macrophage subsets and expression of nitric oxide synthase and arginase isoforms

The Journal of immunology (1950), 2013-07, Vol.191 (2), p.773-784

2013

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Live Imaging of Border Cell Migration in Drosophila

Methods in molecular biology (Clifton, N.J.), 2016-01, Vol.1407, p.153

2016

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A Guide to Rational Dosing of Monoclonal Antibodies

Characterization of the long-term pharmacokinetics of bevacizumab following last dose in patients with resected stage II and III carcinoma of the colon

Preclinical pharmacokinetics of MEHD7945A, a novel EGFR/HER3 dual-action antibody, and prediction of its human pharmacokinetics and efficacious clinical dose

Population pharmacokinetic and pharmacodynamic modeling of MNRP1685A in cynomolgus monkeys using two-target quasi-steady-state (QSS) model

Population pharmacokinetic analysis from phase I and phase II studies of the humanized monovalent antibody, onartuzumab (MetMAb), in patients with advanced solid tumors

Model‐Based Discovery and Development of Biopharmaceuticals: A Case Study of Mavrilimumab

Anti-Neuropilin-1 (MNRP1685A): Unexpected Pharmacokinetic Differences Across Species, from Preclinical Models to Humans

Preclinical pharmacokinetics of MFGR1877A, a human monoclonal antibody to FGFR3, and prediction of its efficacious clinical dose for the treatment of t(4;14)-positive multiple myeloma

Anti-Neuropilin-I (MNRP1685A): Unexpected Pharmacokinetic Differences Across Species, from Preclinical Models to Humans

Human pharmacokinetic (PK) characterization of the novel dual-action anti-HER3/EGFR antibody MEHD7945A (MEHD) in patients with refractory/recurrent epithelial tumors

Chapter 30 - Nonclinical drug development

Nonclinical drug development

Perceived evidence use: Measurement and construct validation of managerial evidence use as perceived by subordinates

Selection-free genome editing of the sickle mutation in human adult hematopoietic stem/progenitor cells

Superresolution imaging of Drosophila tissues using expansion microscopy

Single-cell analysis reveals fibroblast heterogeneity and myeloid-derived adipocyte progenitors in murine skin wounds

Preservation Methods Differ in Fecal Microbiome Stability, Affecting Suitability for Field Studies

RNF7 Induces Skeletal Muscle Cell Apoptosis and Arrests Cell Autophagy via Upregulation of THBS1 and Inactivation of the PI3K/Akt Signaling Pathway in a Rat Sepsis Model

From People to Panthera : Natural SARS-CoV-2 Infection in Tigers and Lions at the Bronx Zoo

Unique features in the intracellular transport of typhoid toxin revealed by a genome-wide screen

Immature dengue virus is infectious in human immature dendritic cells via interaction with the receptor molecule DC-SIGN

Analysis of Key Factors Affecting the Coke Pushing Stability of Coke Pusher

Maternal folic acid supplementation modulates DNA methylation and gene expression in the rat offspring in a gestation period-dependent and organ-specific manner

Microenvironments in tuberculous granulomas are delineated by distinct populations of macrophage subsets and expression of nitric oxide synthase and arginase isoforms

Live Imaging of Border Cell Migration in Drosophila

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