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Synergistic drug combinations for cancer identified in a CRISPR screen for pairwise genetic interactions

Nature biotechnology, 2017-05, Vol.35 (5), p.463-474

2017

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Genome-scale measurement of off-target activity using Cas9 toxicity in high-throughput screens

Nature communications, 2017-05, Vol.8 (1), p.15178-8, Article 15178

2017

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Genome-scale CRISPR screening reveals that C3aR signaling is critical for rapid capture of fungi by macrophages

PLoS pathogens, 2022-09, Vol.18 (9), p.e1010237-e1010237

2022

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Enhancer Activity Requires CBP/P300 Bromodomain-Dependent Histone H3K27 Acetylation

Cell reports (Cambridge), 2018-08, Vol.24 (7), p.1722-1729

2018

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Systematic Identification of Host Cell Regulators of Legionella pneumophila Pathogenesis Using a Genome-wide CRISPR Screen

Cell host & microbe, 2019-10, Vol.26 (4), p.551-563.e6

2019

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Combined Proteomic and Genetic Interaction Mapping Reveals New RAS Effector Pathways and Susceptibilities

Cancer discovery, 2020-12, Vol.10 (12), p.1950-1967

2020

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CBP Modulates Sensitivity to Dasatinib in Pre-BCR + Acute Lymphoblastic Leukemia

Cancer research (Chicago, Ill.), 2018-11, Vol.78 (22), p.6497-6508

2018

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Evaluation of the prevalence of MET and protein tyrosine kinase 7 expression in non-small cell lung cancer to evaluate overlap of ADC antigens

Journal of clinical oncology, 2023-06, Vol.41 (16_suppl), p.e21105-e21105

2023

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Abstract B25: Combined proteomic and genetic interaction mapping reveals new Ras pathway effectors and regulators

Molecular cancer research, 2020-05, Vol.18 (5_Supplement), p.B25-B25

2020

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Abstract PR07: Combinatorial knockout of Rap1GDS1 and RhoA leads to lethality in KRAS-driven non-small cell lung cancer

Molecular cancer research, 2020-05, Vol.18 (5_Supplement), p.PR07-PR07

2020

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Abstract 959: Proteomic and genetic interaction mapping of the Ras pathway reveals new effectors and vulnerabilities

Cancer research (Chicago, Ill.), 2019-07, Vol.79 (13_Supplement), p.959-959

2019

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First-in-human study of ABBV-011, a seizure-related homolog protein 6 (SEZ6)–targeting antibody-drug conjugate, in patients with small cell lung cancer

Journal of clinical oncology, 2023-06, Vol.41 (16_suppl), p.3002-3002

2023

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Abstract PR12: A combined protein-protein interaction and genetic interaction map defines new and critical Kras effectors in non-small cell lung cancer

Clinical cancer research, 2018-09, Vol.24 (17_Supplement), p.PR12-PR12

2018

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Identification of Synergistic Cancer Drug Combinations and Host Modifiers of Legionella Pneumophila Pathogenesis Using CRISPR-Cas9 Screens

Jeng, Edwin

2019

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ProQuest

Abstract PR04: A CRISPR-based genetic interaction map identifies synergistic drug combinations for cancer

Molecular cancer therapeutics, 2017-10, Vol.16 (10_Supplement), p.PR04-PR04

2017

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A phase 1b, open-label, single-arm study of cofetuzumab pelidotin (a PTK7-targeting antibody-drug conjugate) in patients with PTK7-expressing, recurrent non-small cell lung cancer (NSCLC)

Journal of clinical oncology, 2021-05, Vol.39 (15_suppl), p.TPS3142-TPS3142

2021

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Abstract 4362: Identification of novel combinatorial synthetic lethal vulnerabilities in KRAS-driven lung cancer

Cancer research (Chicago, Ill.), 2018-07, Vol.78 (13_Supplement), p.4362-4362

2018

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Abstract PR03: Linking AP/MS-driven protein-protein interaction networks and combination CRISPR/sgRNA screens defines new Kras effectors and target candidates for non-small cell lung cancer

Molecular cancer therapeutics, 2017-10, Vol.16 (10_Supplement), p.PR03-PR03

2017

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Nanonetwork Thermosets from Templated Polymerization for Enhanced Energy Dissipation

Nano letters, 2021-04, Vol.21 (8), p.3355-3363

2021

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American Burn Association consensus conference to define sepsis and infection in burns

Journal of burn care & research, 2007-11, Vol.28 (6), p.776-790

2007

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S2436 Coincidence or Not? A Rare Case of a Mixed Adenoneuroendocrine Rectal Tumor in the Setting of Ulcerative Colitis

The American journal of gastroenterology, 2021-10, Vol.116 (1), p.S1030-S1031

2021

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Mo1511 HOSPITAL TEACHING STATUS ON OUTCOMES IN NONALCOHOLIC FATTY LIVER DISEASE RELATED HOSPITALIZATIONS

Gastroenterology (New York, N.Y. 1943), 2020-05, Vol.158 (6), p.S-1432-S-1433

2020

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Su1706 HOSPITAL TEACHING STATUS ON OUTCOMES IN WILSONS DISEASE

Gastroenterology (New York, N.Y. 1943), 2020-05, Vol.158 (6), p.S-1389-S-1389

2020

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Ticagrelor Added to Aspirin in Acute Nonsevere Ischemic Stroke or Transient Ischemic Attack of Atherosclerotic Origin

Stroke (1970), 2020-12, Vol.51 (12), p.3504-3513

2020

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Synergistic drug combinations for cancer identified in a CRISPR screen for pairwise genetic interactions

Genome-scale measurement of off-target activity using Cas9 toxicity in high-throughput screens

Genome-scale CRISPR screening reveals that C3aR signaling is critical for rapid capture of fungi by macrophages

Enhancer Activity Requires CBP/P300 Bromodomain-Dependent Histone H3K27 Acetylation

Systematic Identification of Host Cell Regulators of Legionella pneumophila Pathogenesis Using a Genome-wide CRISPR Screen

Combined Proteomic and Genetic Interaction Mapping Reveals New RAS Effector Pathways and Susceptibilities

CBP Modulates Sensitivity to Dasatinib in Pre-BCR + Acute Lymphoblastic Leukemia

Evaluation of the prevalence of MET and protein tyrosine kinase 7 expression in non-small cell lung cancer to evaluate overlap of ADC antigens

Abstract B25: Combined proteomic and genetic interaction mapping reveals new Ras pathway effectors and regulators

Abstract PR07: Combinatorial knockout of Rap1GDS1 and RhoA leads to lethality in KRAS-driven non-small cell lung cancer

Abstract 959: Proteomic and genetic interaction mapping of the Ras pathway reveals new effectors and vulnerabilities

First-in-human study of ABBV-011, a seizure-related homolog protein 6 (SEZ6)–targeting antibody-drug conjugate, in patients with small cell lung cancer

Abstract PR12: A combined protein-protein interaction and genetic interaction map defines new and critical Kras effectors in non-small cell lung cancer

Identification of Synergistic Cancer Drug Combinations and Host Modifiers of Legionella Pneumophila Pathogenesis Using CRISPR-Cas9 Screens

Abstract PR04: A CRISPR-based genetic interaction map identifies synergistic drug combinations for cancer

A phase 1b, open-label, single-arm study of cofetuzumab pelidotin (a PTK7-targeting antibody-drug conjugate) in patients with PTK7-expressing, recurrent non-small cell lung cancer (NSCLC)

Abstract 4362: Identification of novel combinatorial synthetic lethal vulnerabilities in KRAS-driven lung cancer

Abstract PR03: Linking AP/MS-driven protein-protein interaction networks and combination CRISPR/sgRNA screens defines new Kras effectors and target candidates for non-small cell lung cancer

The AMBRA1 E3 ligase adaptor regulates the stability of cyclin D

Nanonetwork Thermosets from Templated Polymerization for Enhanced Energy Dissipation

American Burn Association consensus conference to define sepsis and infection in burns

S2436 Coincidence or Not? A Rare Case of a Mixed Adenoneuroendocrine Rectal Tumor in the Setting of Ulcerative Colitis

Mo1511 HOSPITAL TEACHING STATUS ON OUTCOMES IN NONALCOHOLIC FATTY LIVER DISEASE RELATED HOSPITALIZATIONS

Su1706 HOSPITAL TEACHING STATUS ON OUTCOMES IN WILSONS DISEASE

Ticagrelor Added to Aspirin in Acute Nonsevere Ischemic Stroke or Transient Ischemic Attack of Atherosclerotic Origin

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