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Nucleic Acid Ligands With Protein-like Side Chains: Modified Aptamers and Their Use as Diagnostic and Therapeutic Agents

Molecular therapy. Nucleic acids, 2014-10, Vol.3 (10), p.e201-e201, Article e201

2014

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Unique motifs and hydrophobic interactions shape the binding of modified DNA ligands to protein targets

Proceedings of the National Academy of Sciences - PNAS, 2012-12, Vol.109 (49), p.19971-19976

2012

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Protein signature of lung cancer tissues

PloS one, 2012-04, Vol.7 (4), p.e35157-e35157

2012

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Optimization and Lead Selection of Benzothiazole Amide Analogs Toward a Novel Antimycobacterial Agent

Frontiers in microbiology, 2018-09, Vol.9, p.2231-2231

2018

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Non-helical DNA Triplex Forms a Unique Aptamer Scaffold for High Affinity Recognition of Nerve Growth Factor

Structure (London), 2015-07, Vol.23 (7), p.1293-1304

2015

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Structure of PolC reveals unique DNA binding and fidelity determinants

Proceedings of the National Academy of Sciences - PNAS, 2008-12, Vol.105 (52), p.20695-20700

2008

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Geographic Equity and Environmental Sustainability of Conference Models: Results of a Comparative Analysis

The American journal of tropical medicine and hygiene, 2024-05, Vol.110 (5), p.1039-1045

2024

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Discovery and Analysis of 4H-Pyridopyrimidines, a Class of Selective Bacterial Protein Synthesis Inhibitors

Antimicrobial Agents and Chemotherapy, 2010-11, Vol.54 (11), p.4648-4657

2010

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Inhibition of Methionyl-tRNA Synthetase by REP8839 and Effects of Resistance Mutations on Enzyme Activity

Antimicrobial Agents and Chemotherapy, 2009-01, Vol.53 (1), p.86-94

2009

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Chemically Modified DNA Aptamers Bind Interleukin-6 with High Affinity and Inhibit Signaling by Blocking Its Interaction with Interleukin-6 Receptor

The Journal of biological chemistry, 2014-03, Vol.289 (12), p.8706-8719

2014

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Reimagining scientific conferences-a Keystone Symposia report

Annals of the New York Academy of Sciences, 2023-09, Vol.1527 (1), p.49-59

2023

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Crystal Structure of Interleukin-6 in Complex with a Modified Nucleic Acid Ligand

The Journal of biological chemistry, 2014-03, Vol.289 (12), p.8720-8734

2014

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Multiple-Ascending-Dose Phase 1 Clinical Study of the Safety, Tolerability, and Pharmacokinetics of CRS3123, a Narrow-Spectrum Agent with Minimal Disruption of Normal Gut Microbiota

Antimicrobial agents and chemotherapy, 2019-12, Vol.64 (1)

2019

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Safety, Tolerability, Systemic Exposure, and Metabolism of CRS3123, a Methionyl-tRNA Synthetase Inhibitor Developed for Treatment of Clostridium difficile, in a Phase 1 Study

Antimicrobial agents and chemotherapy, 2017-08, Vol.61 (8)

2017

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Microbiological profile, preclinical pharmacokinetics and efficacy of CRS0393, a novel antimycobacterial agent targeting MmpL3

Tuberculosis (Edinburgh, Scotland), 2023-01, Vol.138, p.102288-102288, Article 102288

2023

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Highly multiplexed proteomic platform for biomarker discovery, diagnostics, and therapeutics

Advances in experimental medicine and biology, 2013-01, Vol.735, p.283

2013

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Spectrum of activity and mode of action of REP3123, a new antibiotic to treat Clostridium difficile infections

Journal of antimicrobial chemotherapy, 2009-05, Vol.63 (5), p.954-963

2009

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Reconstitution of a Minimal DNA Replicase from Pseudomonas aeruginosa and Stimulation by Non-cognate Auxiliary Factors

The Journal of biological chemistry, 2005-03, Vol.280 (9), p.7890-7900

2005

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Rapid histochemistry using slow off-rate modified aptamers with anionic competition

Applied immunohistochemistry & molecular morphology, 2011-05, Vol.19 (3), p.273-278

2011

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Discovery and Characterization of the Cryptic Ψ Subunit of the Pseudomonad DNA Replicase

The Journal of biological chemistry, 2005-12, Vol.280 (49), p.40465-40473

2005

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The polymerase in its labyrinth: mechanisms and implications of RNA recombination

Trends in Genetics, 1991-06, Vol.7 (6), p.186-191

1991

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Nuclease-Resistant Ribozymes Decrease Stromelysin mRNA Levels in Rabbit Synovium Following Exogenous Delivery to the Knee Joint

Proceedings of the National Academy of Sciences - PNAS, 1996-01, Vol.93 (2), p.754-758

1996

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Ribozymes as Tools for Therapeutic Target Validation in Arthritis

The Journal of immunology (1950), 2000-07, Vol.165 (1), p.493-498

2000

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Discovery and Analysis of 4 H -Pyridopyrimidines, a Class of Selective Bacterial Protein Synthesis Inhibitors

Antimicrobial agents and chemotherapy, 2010-11, Vol.54 (11), p.4648-4657

2010

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Assembly of the Bacteriophage T4 Replication Machine Requires the Acidic Carboxy Terminus of Gene 32 Protein

Journal of molecular biology, 1993-01, Vol.229 (2), p.398-418

1993

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Nucleic Acid Ligands With Protein-like Side Chains: Modified Aptamers and Their Use as Diagnostic and Therapeutic Agents

Unique motifs and hydrophobic interactions shape the binding of modified DNA ligands to protein targets

Protein signature of lung cancer tissues

Optimization and Lead Selection of Benzothiazole Amide Analogs Toward a Novel Antimycobacterial Agent

Non-helical DNA Triplex Forms a Unique Aptamer Scaffold for High Affinity Recognition of Nerve Growth Factor

Structure of PolC reveals unique DNA binding and fidelity determinants

Geographic Equity and Environmental Sustainability of Conference Models: Results of a Comparative Analysis

Discovery and Analysis of 4H-Pyridopyrimidines, a Class of Selective Bacterial Protein Synthesis Inhibitors

Inhibition of Methionyl-tRNA Synthetase by REP8839 and Effects of Resistance Mutations on Enzyme Activity

Chemically Modified DNA Aptamers Bind Interleukin-6 with High Affinity and Inhibit Signaling by Blocking Its Interaction with Interleukin-6 Receptor

Reimagining scientific conferences-a Keystone Symposia report

Crystal Structure of Interleukin-6 in Complex with a Modified Nucleic Acid Ligand

Multiple-Ascending-Dose Phase 1 Clinical Study of the Safety, Tolerability, and Pharmacokinetics of CRS3123, a Narrow-Spectrum Agent with Minimal Disruption of Normal Gut Microbiota

Safety, Tolerability, Systemic Exposure, and Metabolism of CRS3123, a Methionyl-tRNA Synthetase Inhibitor Developed for Treatment of Clostridium difficile, in a Phase 1 Study

Microbiological profile, preclinical pharmacokinetics and efficacy of CRS0393, a novel antimycobacterial agent targeting MmpL3

Highly multiplexed proteomic platform for biomarker discovery, diagnostics, and therapeutics

Spectrum of activity and mode of action of REP3123, a new antibiotic to treat Clostridium difficile infections

Reconstitution of a Minimal DNA Replicase from Pseudomonas aeruginosa and Stimulation by Non-cognate Auxiliary Factors

Rapid histochemistry using slow off-rate modified aptamers with anionic competition

Discovery and Characterization of the Cryptic Ψ Subunit of the Pseudomonad DNA Replicase

The polymerase in its labyrinth: mechanisms and implications of RNA recombination

Nuclease-Resistant Ribozymes Decrease Stromelysin mRNA Levels in Rabbit Synovium Following Exogenous Delivery to the Knee Joint

Ribozymes as Tools for Therapeutic Target Validation in Arthritis

Discovery and Analysis of 4 H -Pyridopyrimidines, a Class of Selective Bacterial Protein Synthesis Inhibitors

Assembly of the Bacteriophage T4 Replication Machine Requires the Acidic Carboxy Terminus of Gene 32 Protein

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