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Structural principles of insulin formulation and analog design: A century of innovation

Molecular metabolism (Germany), 2021-10, Vol.52, p.101325, Article 101325

2021

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Peptide Model of the Mutant Proinsulin Syndrome. I. Design and Clinical Correlation

Frontiers in endocrinology (Lausanne), 2022-03, Vol.13, p.821069

2022

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‘Smart’ insulin-delivery technologies and intrinsic glucose-responsive insulin analogues

Diabetologia, 2021-05, Vol.64 (5), p.1016-1029

2021

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New Horizons: Next-Generation Insulin Analogues: Structural Principles and Clinical Goals

The journal of clinical endocrinology and metabolism, 2022-03, Vol.107 (4), p.909-928

2022

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Insertion of a synthetic switch into insulin provides metabolite-dependent regulation of hormone-receptor activation

Proceedings of the National Academy of Sciences - PNAS, 2021-07, Vol.118 (30)

2021

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β-Secretase Cleavage of Alzheimer's Amyloid Precursor Protein by the Transmembrane Aspartic Protease BACE

Science (American Association for the Advancement of Science), 1999-10, Vol.286 (5440), p.735-741

1999

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Proteinase-activated receptor-2 mediates hyperresponsiveness in isolated guinea pig bronchi

Biochemical pharmacology, 2003-08, Vol.66 (3), p.519-525

2003

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Design of a new peptidomimetic agonist for the melanocortin receptors based on the solution structure of the peptide ligand, Ac-Nle-cyclo[Asp-Pro-DPhe-Arg-Trp-Lys]-NH2

Bioorganic & medicinal chemistry letters, 2003-07, Vol.13 (14), p.2337-2340

2003

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Structure of a human DNA repair protein UBA domain that interacts with HIV-1 Vpr

Nature structural biology, 1998-12, Vol.5 (12), p.1042-1047

1998

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Solid-Phase Synthesis via 5-Oxazolidinones. Ring-Opening Reactions with Amines and Reaction Monitoring by Single-Bead FT-IR Microspectroscopy

Journal of organic chemistry, 1997-08, Vol.62 (16), p.5615-5618

1997

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Parkinson's Disease-associated α-Synuclein Is More Fibrillogenic than β- and γ-Synuclein and Cannot Cross-seed Its Homologs

The Journal of biological chemistry, 2000-11, Vol.275 (44), p.34574-34579

2000

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Synthesis, chemical reactivity, and antitumor evaluation of congeners of carmethizole hydrochloride, an experimental acylated vinylogous carbinolamine tumor inhibitor

Journal of medicinal chemistry, 1993-11, Vol.36 (23), p.3618-3627

1993

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Lanthionine macrocyclization by in situ activation of serine

The journal of peptide research, 1998-06, Vol.51 (6), p.432-436

1998

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Preparation of noncondensed 2-substituted 1-methylimidazoles via ipso substitution reaction on 2-sulfinyl or 2-sulfonyl derivatives of 4,5-disubstituted 1-methylimidazoles

Journal of organic chemistry, 1991-06, Vol.56 (12), p.4058-4062

1991

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Synthesis of 3-pyrrolines by an intramolecular Wittig reaction

Journal of organic chemistry, 1991-10, Vol.56 (22), p.6475-6477

1991

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Enhanced resolution in MAS NMR for combinatorial chemistry

Tetrahedron letters, 1997-02, Vol.38 (8), p.1333-1336

1997

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Diastereospecific tandem Michael-like addition / electrophilic bromination: A one-pot tandem asymmetric synthesis of precursors of unusual amino acids

Tetrahedron letters, 1993-04, Vol.34 (16), p.2561-2564

1993

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Design of a new peptidomimetic agonist for the melanocortin receptors based on the solution structure of the peptide ligand, Ac-Nle-cyclo[Asp-Pro-DPhe-Arg-Trp-Lys]-NH(2)

Bioorganic & medicinal chemistry letters, 2003-07, Vol.13 (14), p.2337-2340

2003

Volltextzugriff (PDF)

Design of a new peptidomimetic agonist for the melanocortin receptors based on the solution structure of the peptide ligand, Ac-Nle-cyclo[Asp-Pro- dPhe-Arg-Trp-Lys]-NH 2

Bioorganic & medicinal chemistry letters, 2003, Vol.13 (14), p.2337-2340

2003

Volltextzugriff (PDF)

Asymmetric synthesis of unusual amino acids : An enantioselective synthesis of the four isomers of D- and L- O-Methyl-2′, β-Dimethyltyrosine

Tetrahedron letters, 1993-04, Vol.34 (16), p.2565-2568

1993

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Parkinson's Disease-associated Î±-Synuclein Is More Fibrillogenic than Î²- and Î³-Synuclein and Cannot Cross-seed Its Homologs

The Journal of biological chemistry, 2000-11, Vol.275 (44), p.34574

2000

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[Beta]-Secretase Cleavage of Alzheimer's Amyloid Precursor Protein by the Transmembrane Aspartic Protease BACE

Science (American Association for the Advancement of Science), 1999-10, Vol.286 (5440), p.735-735

1999

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Structure, synthesis, and antitumor activity of the hydrolysis product of the antitumor agent carmethizole

Drug development research, 1993-11, Vol.30 (3), p.143-146

1993

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Longitudinal Analysis Reveals Early Development of Three MPER-Directed Neutralizing Antibody Lineages from an HIV-1-Infected Individual

Immunity (Cambridge, Mass.), 2019-03, Vol.50 (3), p.677-691.e13

2019

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Structural principles of insulin formulation and analog design: A century of innovation

Peptide Model of the Mutant Proinsulin Syndrome. I. Design and Clinical Correlation

‘Smart’ insulin-delivery technologies and intrinsic glucose-responsive insulin analogues

New Horizons: Next-Generation Insulin Analogues: Structural Principles and Clinical Goals

Insertion of a synthetic switch into insulin provides metabolite-dependent regulation of hormone-receptor activation

β-Secretase Cleavage of Alzheimer's Amyloid Precursor Protein by the Transmembrane Aspartic Protease BACE

Proteinase-activated receptor-2 mediates hyperresponsiveness in isolated guinea pig bronchi

Design of a new peptidomimetic agonist for the melanocortin receptors based on the solution structure of the peptide ligand, Ac-Nle-cyclo[Asp-Pro-DPhe-Arg-Trp-Lys]-NH2

Structure of a human DNA repair protein UBA domain that interacts with HIV-1 Vpr

Solid-Phase Synthesis via 5-Oxazolidinones. Ring-Opening Reactions with Amines and Reaction Monitoring by Single-Bead FT-IR Microspectroscopy

Parkinson's Disease-associated α-Synuclein Is More Fibrillogenic than β- and γ-Synuclein and Cannot Cross-seed Its Homologs

Synthesis, chemical reactivity, and antitumor evaluation of congeners of carmethizole hydrochloride, an experimental acylated vinylogous carbinolamine tumor inhibitor

Lanthionine macrocyclization by in situ activation of serine

Preparation of noncondensed 2-substituted 1-methylimidazoles via ipso substitution reaction on 2-sulfinyl or 2-sulfonyl derivatives of 4,5-disubstituted 1-methylimidazoles

Synthesis of 3-pyrrolines by an intramolecular Wittig reaction

Enhanced resolution in MAS NMR for combinatorial chemistry

Diastereospecific tandem Michael-like addition / electrophilic bromination: A one-pot tandem asymmetric synthesis of precursors of unusual amino acids

Design of a new peptidomimetic agonist for the melanocortin receptors based on the solution structure of the peptide ligand, Ac-Nle-cyclo[Asp-Pro-DPhe-Arg-Trp-Lys]-NH(2)

Design of a new peptidomimetic agonist for the melanocortin receptors based on the solution structure of the peptide ligand, Ac-Nle-cyclo[Asp-Pro- dPhe-Arg-Trp-Lys]-NH 2

Asymmetric synthesis of unusual amino acids : An enantioselective synthesis of the four isomers of D- and L- O-Methyl-2′, β-Dimethyltyrosine

Parkinson's Disease-associated Î±-Synuclein Is More Fibrillogenic than Î²- and Î³-Synuclein and Cannot Cross-seed Its Homologs

[Beta]-Secretase Cleavage of Alzheimer's Amyloid Precursor Protein by the Transmembrane Aspartic Protease BACE

Structure, synthesis, and antitumor activity of the hydrolysis product of the antitumor agent carmethizole

Structures of HIV-1 Env V1V2 with broadly neutralizing antibodies reveal commonalities that enable vaccine design

Longitudinal Analysis Reveals Early Development of Three MPER-Directed Neutralizing Antibody Lineages from an HIV-1-Infected Individual

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