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Nonclinical Safety Evaluation of scAAV8- RLBP1 for Treatment of RLBP1 Retinitis Pigmentosa

Molecular therapy. Methods & clinical development, 2018-03, Vol.8 (C), p.105-120

2018

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Renal abnormalities and an altered inflammatory response in mice lacking cyclooxygenase II

Nature (London), 1995-11, Vol.378 (6555), p.406-409

1995

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Complement factor B is critical for sub-RPE deposit accumulation in a model of Doyne honeycomb retinal dystrophy with features of age-related macular degeneration

Human molecular genetics, 2023-01, Vol.32 (2), p.204-217

2023

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Reliability of the mouse model of choroidal neovascularization induced by laser photocoagulation

Investigative ophthalmology & visual science, 2014-09, Vol.55 (10), p.6525-6534

2014

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AAV-mediated RLBP1 gene therapy improves the rate of dark adaptation in Rlbp1 knockout mice

Molecular therapy. Methods & clinical development, 2015-01, Vol.2, p.15022-15022, Article 15022

2015

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Discovery of 4-((2 S ,4 S )-4-Ethoxy-1-((5-methoxy-7-methyl-1 H -indol-4-yl)methyl)piperidin-2-yl)benzoic Acid (LNP023), a Factor B Inhibitor Specifically Designed To Be Applicable to Treating a Diverse Array of Complement Mediated Diseases

Journal of medicinal chemistry, 2020-06, Vol.63 (11), p.5697-5722

2020

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Induction of Ocular Complement Activation by Inflammatory Stimuli and Intraocular Inhibition of Complement Factor D in Animal Models

Investigative ophthalmology & visual science, 2018-02, Vol.59 (2), p.940-951

2018

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Specific correlation between the major chromosome 10q26 haplotype conferring risk for age-related macular degeneration and the expression of HTRA1

Molecular vision, 2017, Vol.23, p.318-333

2017

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Amount of Mononuclear Phagocyte Infiltrate Does Not Predict Area of Experimental Choroidal Neovascularization (CNV)

Journal of ocular pharmacology and therapeutics, 2018-09, Vol.34 (7), p.489

2018

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Inhibition of Mitogen-Activated Protein Kinase Kinase Blocks T Cell Proliferation But Does Not Induce or Prevent Anergy

The Journal of immunology (1950), 1998-05, Vol.160 (9), p.4175-4181

1998

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Design, Synthesis, and Structure−Activity Relationships of Macrocyclic Hydroxamic Acids That Inhibit Tumor Necrosis Factor α Release in Vitro and in Vivo

Journal of medicinal chemistry, 2001-08, Vol.44 (16), p.2636-2660

2001

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Discovery of Macrocyclic Hydroxamic Acids Containing Biphenylmethyl Derivatives at P1‘, a Series of Selective TNF-α Converting Enzyme Inhibitors with Potent Cellular Activity in the Inhibition of TNF-α Release

Journal of medicinal chemistry, 2001-10, Vol.44 (21), p.3351-3354

2001

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Inhibition of MAP Kinase Kinase (MEK) Results in an Anti-inflammatory Response in Vivo

Biochemical and biophysical research communications, 2000-02, Vol.268 (2), p.647-651

2000

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Design and Synthesis of Cyclic Inhibitors of Matrix Metalloproteinases and TNF-α Production

Journal of medicinal chemistry, 1998-05, Vol.41 (11), p.1745-1748

1998

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The effect of a new immunosuppressive drug, brequinar sodium, on heart, liver, and kidney allograft rejection in the rat

Transplantation, 1992-02, Vol.53 (2), p.303

1992

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Characterizing kidney and eye pathology of complement factor H deficient mice

Molecular immunology, 2010-08, Vol.47 (13), p.2281-2281

2010

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Structure-activity relationships (SAR) of some tetracyclic heterocycles related to the immunosuppressive agent brequinar sodium

Bioorganic & medicinal chemistry letters, 1998-02, Vol.8 (3), p.307-312

1998

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COMPARISON OF SNAKE VENOM REPROLYSIN AND MATRIX METALLOPROTEINASES AS MODELS OF TNF-α CONVERTING ENZYME

Bioorganic & medicinal chemistry letters, 1997-05, Vol.7 (10), p.1219-1224

1997

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A selective small molecule IkappaB Kinase beta inhibitor blocks nuclear factor kappaB-mediated inflammatory responses in human fibroblast-like synoviocytes, chondrocytes, and mast cells

The Journal of pharmacology and experimental therapeutics, 2006-06, Vol.317 (3), p.989

2006

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Macrocyclic hydroxamate inhibitors of matrix metalloproteinases and TNF-α production

Bioorganic & medicinal chemistry letters, 1999-05, Vol.9 (9), p.1279-1284

1999

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Heteroatom- and carbon-linked biphenyl analogs of Brequinar as immunosuppressive agents

Bioorganic & medicinal chemistry letters, 1998-07, Vol.8 (13), p.1745-1750

1998

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Minor antigen graft-versus-host reactions revealed in irradiated spleen and popliteal lymph node assays

Transplantation, 1984-10, Vol.38 (4), p.392

1984

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Chronic graft-versus-host disease (GVHD) as a model for scleroderma

Cellular immunology, 1983-04, Vol.77 (1), p.1-12

1983

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Chronic graft-versus-host disease as a model for scleroderma

Cellular immunology, 1985-08, Vol.94 (1), p.73-84

1985

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The prolongation of concordant hamster-to-rat cardiac xenografts by brequinar sodium

Transplantation, 1992-09, Vol.54 (3), p.403

1992

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Nonclinical Safety Evaluation of scAAV8- RLBP1 for Treatment of RLBP1 Retinitis Pigmentosa

Renal abnormalities and an altered inflammatory response in mice lacking cyclooxygenase II

Complement factor B is critical for sub-RPE deposit accumulation in a model of Doyne honeycomb retinal dystrophy with features of age-related macular degeneration

Reliability of the mouse model of choroidal neovascularization induced by laser photocoagulation

AAV-mediated RLBP1 gene therapy improves the rate of dark adaptation in Rlbp1 knockout mice

Discovery of 4-((2 S ,4 S )-4-Ethoxy-1-((5-methoxy-7-methyl-1 H -indol-4-yl)methyl)piperidin-2-yl)benzoic Acid (LNP023), a Factor B Inhibitor Specifically Designed To Be Applicable to Treating a Diverse Array of Complement Mediated Diseases

Induction of Ocular Complement Activation by Inflammatory Stimuli and Intraocular Inhibition of Complement Factor D in Animal Models

Specific correlation between the major chromosome 10q26 haplotype conferring risk for age-related macular degeneration and the expression of HTRA1

Amount of Mononuclear Phagocyte Infiltrate Does Not Predict Area of Experimental Choroidal Neovascularization (CNV)

Inhibition of Mitogen-Activated Protein Kinase Kinase Blocks T Cell Proliferation But Does Not Induce or Prevent Anergy

Design, Synthesis, and Structure−Activity Relationships of Macrocyclic Hydroxamic Acids That Inhibit Tumor Necrosis Factor α Release in Vitro and in Vivo

Discovery of Macrocyclic Hydroxamic Acids Containing Biphenylmethyl Derivatives at P1‘, a Series of Selective TNF-α Converting Enzyme Inhibitors with Potent Cellular Activity in the Inhibition of TNF-α Release

Inhibition of MAP Kinase Kinase (MEK) Results in an Anti-inflammatory Response in Vivo

Design and Synthesis of Cyclic Inhibitors of Matrix Metalloproteinases and TNF-α Production

The effect of a new immunosuppressive drug, brequinar sodium, on heart, liver, and kidney allograft rejection in the rat

Characterizing kidney and eye pathology of complement factor H deficient mice

Structure-activity relationships (SAR) of some tetracyclic heterocycles related to the immunosuppressive agent brequinar sodium

COMPARISON OF SNAKE VENOM REPROLYSIN AND MATRIX METALLOPROTEINASES AS MODELS OF TNF-α CONVERTING ENZYME

A selective small molecule IkappaB Kinase beta inhibitor blocks nuclear factor kappaB-mediated inflammatory responses in human fibroblast-like synoviocytes, chondrocytes, and mast cells

Macrocyclic hydroxamate inhibitors of matrix metalloproteinases and TNF-α production

Heteroatom- and carbon-linked biphenyl analogs of Brequinar as immunosuppressive agents

Minor antigen graft-versus-host reactions revealed in irradiated spleen and popliteal lymph node assays

Chronic graft-versus-host disease (GVHD) as a model for scleroderma

Chronic graft-versus-host disease as a model for scleroderma

The prolongation of concordant hamster-to-rat cardiac xenografts by brequinar sodium

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