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Alzheimer's Disease: From Pathology to Therapeutic Approaches

Angewandte Chemie (International ed.), 2009-04, Vol.48 (17), p.3030-3059

2009

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BACE1 inhibitors: A head group scan on a series of amides

Bioorganic & medicinal chemistry letters, 2013-07, Vol.23 (14), p.4239-4243

2013

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ProNGF inhibits NGF-mediated TrkA activation in PC12 cells

Journal of neurochemistry, 2008-12, Vol.107 (5), p.1294-1303

2008

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Altered metabolic profile in the frontal cortex of PS2APP transgenic mice, monitored throughout their life span

Neurobiology of disease, 2005-02, Vol.18 (1), p.32-39

2005

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In vitro pharmacological selectivity profile of oseltamivir prodrug (Tamiflu ®) and active metabolite

European journal of pharmacology, 2010-02, Vol.628 (1), p.6-10

2010

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Combined treatment with a BACE inhibitor and anti-Aβ antibody gantenerumab enhances amyloid reduction in APPLondon mice

The Journal of neuroscience, 2014-08, Vol.34 (35), p.11621-11630

2014

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Amyloidogenic Function of the Alzheimer's Disease-Associated Presenilin 1 in the Absence of Endoproteolysis

Biochemistry (Easton), 1999-11, Vol.38 (44), p.14600-14605

1999

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Presenilins Are Processed by Caspase-type Proteases

The Journal of biological chemistry, 1997-08, Vol.272 (33), p.20655-20659

1997

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Hepatitis C Virus Core Protein: Carboxy-Terminal Boundaries of Two Processed Species Suggest Cleavage by a Signal Peptide Peptidase

Virology (New York, N.Y.), 1996-10, Vol.224 (1), p.93-104

1996

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Characterization of human immunodeficiency virus type 1 mutantswith decreased sensitivity to proteinase inhibitor Ro 31-8959

Virology (New York, N.Y.), 1995, Vol.206 (1), p.527-534

1995

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Morphologic and Functional Effects of Gamma Secretase Inhibition on Splenic Marginal Zone B Cells

International journal of alzheimer's disease, 2012, Vol.2012, p.289412-7

2012

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A subcutaneous cellular implant for passive immunization against amyloid-β reduces brain amyloid and tau pathologies

Brain (London, England : 1878), 2016-05, Vol.139 (Pt 5), p.1587-1604

2016

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β‑Secretase (BACE1) Inhibitors with High in Vivo Efficacy Suitable for Clinical Evaluation in Alzheimer’s Disease

Journal of medicinal chemistry, 2013-05, Vol.56 (10), p.3980-3995

2013

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Preclinical Profile of a Potent γ-Secretase Inhibitor Targeting Notch Signaling with In vivo Efficacy and Pharmacodynamic Properties

Cancer research (Chicago, Ill.), 2009-10, Vol.69 (19), p.7672-7680

2009

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Generation of Aβ38 and Aβ42 Is Independently and Differentially Affected by Familial Alzheimer Disease-associated Presenilin Mutations and γ-Secretase Modulation

The Journal of biological chemistry, 2008-01, Vol.283 (2), p.677-683

2008

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RO6807936 as a novel positron emission tomography (PET) radiotracer for in vitro and in vivo visualization and quantification of beta‐site amyloid precursor protein cleaving enzyme (BACE1) in the rodent and baboon brain

Journal of labelled compounds & radiopharmaceuticals, 2023-07, Vol.66 (9), p.222-236

2023

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Cargo Delivery into the Brain by in vivo identified Transport Peptides

Scientific reports, 2015-09, Vol.5 (1), p.14104-14104, Article 14104

2015

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Expression of Transgenic APP mRNA Is the Key Determinant for Beta-Amyloid Deposition in PS2APP Transgenic Mice

Neuro-degenerative diseases, 2009-01, Vol.6 (1-2), p.29-36

2009

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Combined Treatment with a BACE Inhibitor and Anti-Aβ Antibody Gantenerumab Enhances Amyloid Reduction in APP London Mice

The Journal of neuroscience, 2014-08, Vol.34 (35), p.11621-11630

2014

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Combined Treatment with a BACE Inhibitor and Anti-A beta Antibody Gantenerumab Enhances Amyloid Reduction in APP sub(London) Mice

The Journal of neuroscience, 2014-08, Vol.34 (35), p.11621-11630

2014

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Subcellular Localization of Wild-Type and Parkinson's Disease-Associated Mutant alpha -Synuclein in Human and Transgenic Mouse Brain

The Journal of neuroscience, 2000-09, Vol.20 (17), p.6365-6373

2000

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Genetic engineering of cell lines using lentiviral vectors to achieve antibody secretion following encapsulated implantation

Biomaterials, 2014-01, Vol.35 (2), p.792-802

2014

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Aminothiazoles as γ-secretase modulators

Bioorganic & medicinal chemistry letters, 2011-11, Vol.21 (21), p.6554-6558

2011

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Hyperphosphorylation and insolubility of α-synuclein in transgenic mouse oligodendrocytes

EMBO reports, 2002-06, Vol.3 (6), p.583-588

2002

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PS2APP Transgenic Mice, Coexpressing hPS2mut and hAPPswe, Show Age-Related Cognitive Deficits Associated with Discrete Brain Amyloid Deposition and Inflammation

The Journal of neuroscience, 2003-10, Vol.23 (26), p.8989-9003

2003

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Alzheimer's Disease: From Pathology to Therapeutic Approaches

BACE1 inhibitors: A head group scan on a series of amides

ProNGF inhibits NGF-mediated TrkA activation in PC12 cells

Altered metabolic profile in the frontal cortex of PS2APP transgenic mice, monitored throughout their life span

In vitro pharmacological selectivity profile of oseltamivir prodrug (Tamiflu ®) and active metabolite

Combined treatment with a BACE inhibitor and anti-Aβ antibody gantenerumab enhances amyloid reduction in APPLondon mice

Amyloidogenic Function of the Alzheimer's Disease-Associated Presenilin 1 in the Absence of Endoproteolysis

Presenilins Are Processed by Caspase-type Proteases

Hepatitis C Virus Core Protein: Carboxy-Terminal Boundaries of Two Processed Species Suggest Cleavage by a Signal Peptide Peptidase

Characterization of human immunodeficiency virus type 1 mutantswith decreased sensitivity to proteinase inhibitor Ro 31-8959

Morphologic and Functional Effects of Gamma Secretase Inhibition on Splenic Marginal Zone B Cells

A subcutaneous cellular implant for passive immunization against amyloid-β reduces brain amyloid and tau pathologies

β‑Secretase (BACE1) Inhibitors with High in Vivo Efficacy Suitable for Clinical Evaluation in Alzheimer’s Disease

Preclinical Profile of a Potent γ-Secretase Inhibitor Targeting Notch Signaling with In vivo Efficacy and Pharmacodynamic Properties

Generation of Aβ38 and Aβ42 Is Independently and Differentially Affected by Familial Alzheimer Disease-associated Presenilin Mutations and γ-Secretase Modulation

RO6807936 as a novel positron emission tomography (PET) radiotracer for in vitro and in vivo visualization and quantification of beta‐site amyloid precursor protein cleaving enzyme (BACE1) in the rodent and baboon brain

Cargo Delivery into the Brain by in vivo identified Transport Peptides

Expression of Transgenic APP mRNA Is the Key Determinant for Beta-Amyloid Deposition in PS2APP Transgenic Mice

Combined Treatment with a BACE Inhibitor and Anti-Aβ Antibody Gantenerumab Enhances Amyloid Reduction in APP London Mice

Combined Treatment with a BACE Inhibitor and Anti-A beta Antibody Gantenerumab Enhances Amyloid Reduction in APP sub(London) Mice

Subcellular Localization of Wild-Type and Parkinson's Disease-Associated Mutant alpha -Synuclein in Human and Transgenic Mouse Brain

Genetic engineering of cell lines using lentiviral vectors to achieve antibody secretion following encapsulated implantation

Aminothiazoles as γ-secretase modulators

Hyperphosphorylation and insolubility of α-synuclein in transgenic mouse oligodendrocytes

PS2APP Transgenic Mice, Coexpressing hPS2mut and hAPPswe, Show Age-Related Cognitive Deficits Associated with Discrete Brain Amyloid Deposition and Inflammation

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