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Chemical carcinogen safety testing: OECD expert group international consensus on the development of an integrated approach for the testing and assessment of chemical non-genotoxic carcinogens

Archives of toxicology, 2020-08, Vol.94 (8), p.2899-2923

2020

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Integration of Epigenetic Mechanisms into Non-Genotoxic Carcinogenicity Hazard Assessment: Focus on DNA Methylation and Histone Modifications

International journal of molecular sciences, 2021-10, Vol.22 (20), p.10969

2021

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Analyses of Transcriptomics Cell Signalling for Pre-Screening Applications in the Integrated Approach for Testing and Assessment of Non-Genotoxic Carcinogens

International journal of molecular sciences, 2022-11, Vol.23 (21), p.12718

2022

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Marked for Life: Epigenetic Effects of Endocrine Disrupting Chemicals

Annual review of environment and resources, 2017-10, Vol.42 (1), p.105-160

2017

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Increased Cell Proliferation as a Key Event in Chemical Carcinogenesis: Application in an Integrated Approach for the Testing and Assessment of Non-Genotoxic Carcinogenesis

International journal of molecular sciences, 2023-09, Vol.24 (17), p.13246

2023

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A comprehensive view on mechanistic approaches for cancer risk assessment of non-genotoxic agrochemicals

Regulatory toxicology and pharmacology, 2020-12, Vol.118, p.104789, Article 104789

2020

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Mechanistic Interrogation of Cell Transformation In Vitro: The Transformics Assay as an Exemplar of Oncotransformation

International journal of molecular sciences, 2022-07, Vol.23 (14), p.7603

2022

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Dying for change: A roadmap to refine the fish acute toxicity test after 40 years of applying a lethal endpoint

Ecotoxicology and environmental safety, 2021-10, Vol.223, p.112585-112585, Article 112585

2021

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Investigation of Selected Persistent Organic Pollutants in Farmed Atlantic Salmon (Salmo salar), Salmon Aquaculture Feed, and Fish Oil Components of the Feed

Environmental science & technology, 2002-07, Vol.36 (13), p.2797-2805

2002

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OECD workshop consensus report: Ethical considerations with respect to human derived products, specifically human serum, in OECD test guidelines

Frontiers in toxicology, 2023-02, Vol.5, p.1140698-1140698

2023

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A modular strategy for the testing and assessment of non-genotoxic carcinogens

Archives of toxicology, 2024-05

2024

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Lignans, bacteriocides and organochlorine compounds activate the human pregnane X receptor (PXR)

Toxicology and applied pharmacology, 2005-12, Vol.209 (2), p.123-133

2005

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Compound lipophilicity for substrate binding to human P450s in drug metabolism

Drug Discovery Today, 2004-06, Vol.9 (12), p.530-537

2004

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Environmentally induced epigenetic toxicity: potential public health concerns

Critical reviews in toxicology, 2016-09, Vol.46 (8), p.676-700

2016

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Time Trend Investigation of PCBs, PBDEs, and Organochlorine Pesticides in Selected n−3 Polyunsaturated Fatty Acid Rich Dietary Fish Oil and Vegetable Oil Supplements; Nutritional Relevance for Human Essential n−3 Fatty Acid Requirements

Journal of agricultural and food chemistry, 2004-03, Vol.52 (6), p.1780-1788

2004

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Potential of concentration-response data to broaden regulatory application of in vitro test guidelines

ALTEX, alternatives to animal experimentation, 2022-01, Vol.39 (2), p.315–321-315–321

2022

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Avoiding a reproducibility crisis in regulatory toxicology—on the fundamental role of ring trials

Archives of toxicology, 2024-07, Vol.98 (7), p.2047-2063

2024

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The transformics assay: first steps for the development of an integrated approach to investigate the malignant cell transformation in vitro

Carcinogenesis (New York), 2018-07, Vol.39 (7), p.955-967

2018

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Use of New Approach Methodologies (NAMs) in regulatory decisions for chemical safety: Report from an EPAA Deep Dive Workshop

Regulatory toxicology and pharmacology, 2022-11, Vol.135, p.105261-105261, Article 105261

2022

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Weight of evidence evaluation of the metabolism disrupting effects of triphenyl phosphate using an expert knowledge elicitation approach

Toxicology and applied pharmacology, 2024-08, Vol.489, p.116995, Article 116995

2024

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Uncertainties of testing methods: What do we (want to) know about carcinogenicity?

ALTEX, alternatives to animal experimentation, 2017, Vol.34 (2), p.235-252

2017

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International regulatory needs for development of an IATA for non-genotoxic carcinogenic chemical substances

ALTEX, alternatives to animal experimentation, 2016-01, Vol.33 (4), p.359

2016

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Characterisation and validation of an in vitro transactivation assay based on the 22Rv1/MMTV_GR-KO cell line to detect human androgen receptor agonists and antagonists

Food and chemical toxicology, 2021-06, Vol.152, p.112206, Article 112206

2021

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Addressing potential ethical issues regarding the supply of human-derived products or reagents in in vitro OECD Test Guidelines

ALTEX, alternatives to animal experimentation, 2019-01, Vol.36 (2), p.163-176

2019

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The transformics assay: first steps for the development of an integrated approach to investigate the malignant cell transformation in vitro

Carcinogenesis (New York), 2018-07, Vol.39 (7), p.968-968

2018

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Chemical carcinogen safety testing: OECD expert group international consensus on the development of an integrated approach for the testing and assessment of chemical non-genotoxic carcinogens

Integration of Epigenetic Mechanisms into Non-Genotoxic Carcinogenicity Hazard Assessment: Focus on DNA Methylation and Histone Modifications

Analyses of Transcriptomics Cell Signalling for Pre-Screening Applications in the Integrated Approach for Testing and Assessment of Non-Genotoxic Carcinogens

Marked for Life: Epigenetic Effects of Endocrine Disrupting Chemicals

Increased Cell Proliferation as a Key Event in Chemical Carcinogenesis: Application in an Integrated Approach for the Testing and Assessment of Non-Genotoxic Carcinogenesis

A comprehensive view on mechanistic approaches for cancer risk assessment of non-genotoxic agrochemicals

Mechanistic Interrogation of Cell Transformation In Vitro: The Transformics Assay as an Exemplar of Oncotransformation

Dying for change: A roadmap to refine the fish acute toxicity test after 40 years of applying a lethal endpoint

Investigation of Selected Persistent Organic Pollutants in Farmed Atlantic Salmon (Salmo salar), Salmon Aquaculture Feed, and Fish Oil Components of the Feed

OECD workshop consensus report: Ethical considerations with respect to human derived products, specifically human serum, in OECD test guidelines

A modular strategy for the testing and assessment of non-genotoxic carcinogens

Lignans, bacteriocides and organochlorine compounds activate the human pregnane X receptor (PXR)

Compound lipophilicity for substrate binding to human P450s in drug metabolism

Environmentally induced epigenetic toxicity: potential public health concerns

Time Trend Investigation of PCBs, PBDEs, and Organochlorine Pesticides in Selected n−3 Polyunsaturated Fatty Acid Rich Dietary Fish Oil and Vegetable Oil Supplements; Nutritional Relevance for Human Essential n−3 Fatty Acid Requirements

Potential of concentration-response data to broaden regulatory application of in vitro test guidelines

Avoiding a reproducibility crisis in regulatory toxicology—on the fundamental role of ring trials

The transformics assay: first steps for the development of an integrated approach to investigate the malignant cell transformation in vitro

Use of New Approach Methodologies (NAMs) in regulatory decisions for chemical safety: Report from an EPAA Deep Dive Workshop

Weight of evidence evaluation of the metabolism disrupting effects of triphenyl phosphate using an expert knowledge elicitation approach

Uncertainties of testing methods: What do we (want to) know about carcinogenicity?

International regulatory needs for development of an IATA for non-genotoxic carcinogenic chemical substances

Characterisation and validation of an in vitro transactivation assay based on the 22Rv1/MMTV_GR-KO cell line to detect human androgen receptor agonists and antagonists

Addressing potential ethical issues regarding the supply of human-derived products or reagents in in vitro OECD Test Guidelines

The transformics assay: first steps for the development of an integrated approach to investigate the malignant cell transformation in vitro

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