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Current Therapeutic Landscape and Safety Roadmap for Targeting the Aryl Hydrocarbon Receptor in Inflammatory Gastrointestinal Indications

Cells (Basel, Switzerland), 2022-05, Vol.11 (10), p.1708

2022

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Drug Discovery Toxicology: From Target Assessment to Translational Biomarkers

Yvonne Will, J. Eric McDuffie, Andrew J. Olaharski, Brandon D. Jeffy, Yvonne Will, J. Eric McDuffie, Andrew J. Olaharski, Brandon D. Jeffy

1, 2016

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Conjugated Linoleic Acid Inhibits Cell Proliferation through a p53-Dependent Mechanism: Effects on the Expression of G1-Restriction Points in Breast and Colon Cancer Cells

The Journal of nutrition, 2003-11, Vol.133 (11), p.3670-3677

2003

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An Estrogen Receptor-α/p300 Complex Activates the BRCA-1 Promoter at an AP-1 Site That Binds Jun/Fos Transcription Factors: Repressive Effects of p53 on BRCA-1 Transcription

Neoplasia (New York, N.Y.), 2005-09, Vol.7 (9), p.873-882

2005

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Retrospective Analysis of Chemical Structure-Based in silico Prediction of Primary Drug Target and Off-Targets

Computational toxicology, 2023-05, Vol.26, p.100273, Article 100273

2023

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Disruption of Cell Cycle Kinetics by Benzo[a]pyrene: Inverse Expression Patterns of BRCA-1 and p53 in MCF-7 Cells Arrested in S and G2

Neoplasia (New York, N.Y.), 2000-09, Vol.2 (5), p.460-470

2000

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Epigenetics of breast cancer: Polycyclic aromatic hydrocarbons as risk factors

Environmental and molecular mutagenesis, 2002, Vol.39 (2-3), p.235-244

2002

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Activation of the aromatic hydrocarbon receptor pathway is not sufficient for transcriptional repression of BRCA-1: Requirements for metabolism of benzo[a]pyrene to 7r, 8t-dihydroxy-9t, 10-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene

Cancer research (Chicago, Ill.), 2002, Vol.62 (1), p.113-121

2002

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Deoxycholate, an Endogenous Tumor Promoter and DNA Damaging Agent, Modulates BRCA-1 Expression in Apoptosis-Sensitive Epithelial Cells: Loss of BRCA-1 Expression in Colonic Adenocarcinomas

Nutrition and cancer, 2003-01, Vol.46 (1), p.82-92

2003

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Conjugated linoleic acid inhibits cell proliferation through a p53-dependent mechanism: Effects on the expression of G1-restriction points in breast and colon cancer cells1

The Journal of nutrition, 2003-11, Vol.133 (11), p.3670

2003

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Inhibition of BRCA-1 expression by benzo[a]pyrene and its diol epoxide

Molecular carcinogenesis, 1999-10, Vol.26 (2), p.100-118

1999

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An Estrogen Receptor-α/p300 Complex Activates the BRCA-1 Promoter at an AP-1 Site That Binds Jun/Fos Transcription Factors: Repressive Effects of p53 on BRCA-1 Transcription1

Neoplasia (New York, N.Y.), 2005-09, Vol.7 (9), p.873-882

2005

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Toxicogenomics in Drug Discovery Toxicology

Drug Discovery Toxicology, 2016, p.509-529

2016

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Assessing and Predicting Drug‐Induced Kidney Injury, Functional Change, and Safety in Preclinical Studies in Rats

Drug Discovery Toxicology, 2016, p.429-442

2016

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Animal Models of Disease for Future Toxicity Predictions

Drug Discovery Toxicology, 2016, p.261-297

2016

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The Use of Genetically Modified Animals in Discovery Toxicology

Drug Discovery Toxicology, 2016, p.298-313

2016

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Mouse Population‐Based Toxicology for Personalized Medicine and Improved Safety Prediction

Drug Discovery Toxicology, 2016, p.314-329

2016

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Issue Investigation and Practices in Discovery Toxicology

Drug Discovery Toxicology, 2016, p.530-539

2016

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Stem Cell‐Derived Renal Cells and Predictive Renal In Vitro Models

Drug Discovery Toxicology, 2016, p.365-383

2016

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The Need for Human Exposure Projection in the Interpretation of Preclinical In Vitro and In Vivo ADME Tox Data

Drug Discovery Toxicology, 2016, p.67-81

2016

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Emerging Technologies and their Role in Regulatory Review

Drug Discovery Toxicology, 2016, p.1-11

2016

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Safety Assessment Strategies and Predictive Safety of Biopharmaceuticals and Antibody Drug Conjugates

Drug Discovery Toxicology, 2016, p.27-38

2016

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Discovery and Development Strategies for Small Interfering RNAs

Drug Discovery Toxicology, 2016, p.39-51

2016

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Liver

Drug Discovery Toxicology, 2016, p.93-129

2016

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Cardiac

Drug Discovery Toxicology, 2016, p.130-159

2016

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Current Therapeutic Landscape and Safety Roadmap for Targeting the Aryl Hydrocarbon Receptor in Inflammatory Gastrointestinal Indications

Drug Discovery Toxicology: From Target Assessment to Translational Biomarkers

Conjugated Linoleic Acid Inhibits Cell Proliferation through a p53-Dependent Mechanism: Effects on the Expression of G1-Restriction Points in Breast and Colon Cancer Cells

An Estrogen Receptor-α/p300 Complex Activates the BRCA-1 Promoter at an AP-1 Site That Binds Jun/Fos Transcription Factors: Repressive Effects of p53 on BRCA-1 Transcription

Retrospective Analysis of Chemical Structure-Based in silico Prediction of Primary Drug Target and Off-Targets

Disruption of Cell Cycle Kinetics by Benzo[a]pyrene: Inverse Expression Patterns of BRCA-1 and p53 in MCF-7 Cells Arrested in S and G2

Epigenetics of breast cancer: Polycyclic aromatic hydrocarbons as risk factors

Activation of the aromatic hydrocarbon receptor pathway is not sufficient for transcriptional repression of BRCA-1: Requirements for metabolism of benzo[a]pyrene to 7r, 8t-dihydroxy-9t, 10-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene

Deoxycholate, an Endogenous Tumor Promoter and DNA Damaging Agent, Modulates BRCA-1 Expression in Apoptosis-Sensitive Epithelial Cells: Loss of BRCA-1 Expression in Colonic Adenocarcinomas

Conjugated linoleic acid inhibits cell proliferation through a p53-dependent mechanism: Effects on the expression of G1-restriction points in breast and colon cancer cells1

Inhibition of BRCA-1 expression by benzo[a]pyrene and its diol epoxide

An Estrogen Receptor-α/p300 Complex Activates the BRCA-1 Promoter at an AP-1 Site That Binds Jun/Fos Transcription Factors: Repressive Effects of p53 on BRCA-1 Transcription1

Toxicogenomics in Drug Discovery Toxicology

Assessing and Predicting Drug‐Induced Kidney Injury, Functional Change, and Safety in Preclinical Studies in Rats

Animal Models of Disease for Future Toxicity Predictions

The Use of Genetically Modified Animals in Discovery Toxicology

Mouse Population‐Based Toxicology for Personalized Medicine and Improved Safety Prediction

Issue Investigation and Practices in Discovery Toxicology

Stem Cell‐Derived Renal Cells and Predictive Renal In Vitro Models

The Need for Human Exposure Projection in the Interpretation of Preclinical In Vitro and In Vivo ADME Tox Data

Emerging Technologies and their Role in Regulatory Review

Safety Assessment Strategies and Predictive Safety of Biopharmaceuticals and Antibody Drug Conjugates

Discovery and Development Strategies for Small Interfering RNAs

Liver

Cardiac

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