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Na, K-ATPase α3 is a death target of Alzheimer patient amyloid-β assembly

Proceedings of the National Academy of Sciences - PNAS, 2015-08, Vol.112 (32), p.E4465-E4474

2015

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Synthesis and biological evaluation of quinones derived from natural product komaroviquinone as anti-Trypanosoma cruzi agents

Bioorganic & medicinal chemistry letters, 2015-08, Vol.25 (15), p.2967-2971

2015

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化学反応に最適な酵素を予測するための機械学習を用いたEC番号予測モデルの開発

生物工学会誌, 2024/04/25, Vol.102(4), pp.169-175

2024

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A novel derivative (GTN024) from a natural product, komaroviquinone, induced the apoptosis of high-risk myeloma cells via reactive oxygen production and ER stress

Biochemical and biophysical research communications, 2018-11, Vol.505 (3), p.787-793

2018

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GTN057, a komaroviquinone derivative, induced myeloma cells' death in vivo and inhibited c‐MET tyrosine kinase

Cancer medicine (Malden, MA), 2023-04, Vol.12 (8), p.9749-9759

2023

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A short and efficient asymmetric synthesis of komaroviquinone

Tetrahedron letters, 2010-12, Vol.51 (48), p.6329-6330

2010

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Synthesis and biological evaluation of the natural product komaroviquinone and related compounds aiming at a potential therapeutic lead compound for high-risk multiple myeloma

Bioorganic & medicinal chemistry letters, 2017-10, Vol.27 (19), p.4558-4563

2017

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Effect of Cathepsin K Inhibitors on Bone Resorption

Journal of medicinal chemistry, 2008-09, Vol.51 (17), p.5459-5462

2008

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Development of EC number prediction model using machine learning to predict the optimal enzyme for a chemical reaction

Seibutsu-kogaku Kaishi, 2024/04/25, Vol.102(4), pp.169-175

2024

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Na, K-ATPase alpha 3 is a death target of Alzheimer patient amyloid- beta assembly

Proceedings of the National Academy of Sciences - PNAS, 2015-08, Vol.112 (32), p.E4465-E4465

2015

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Komaroviquinone-Derivatives, Revealed Anti-Tumor Effect on High-Risk Multiple Myeloma Cells In Vitro as Well as In Vivo

Blood, 2016-12, Vol.128 (22), p.2100-2100

2016

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Na, K-ATPase [Alpha]3 is a death target of Alzheimer patient amyloid-[Beta] assembly

Proceedings of the National Academy of Sciences - PNAS, 2015-08, Vol.112 (32), p.E4465

2015

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A Novel Class of Herbicides: Specific Inhibitors of Imidazoleglycerol Phosphate Dehydratase

Plant physiology (Bethesda), 1995-03, Vol.107 (3), p.719-723

1995

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Discovery of Orally Bioavailable Cathepsin S Inhibitors for the Reversal of Neuropathic Pain

Journal of medicinal chemistry, 2008-09, Vol.51 (18), p.5502-5505

2008

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Novel scaffold for cathepsin K inhibitors

Bioorganic & medicinal chemistry, 2007-11, Vol.17 (22), p.6096-6100

2007

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Synthesis of Inhibitors of Imidazole Glycerol Phosphate Dehydratase

Journal of the American Chemical Society, 1995-04, Vol.117 (15), p.4411-4412

1995

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New chemotypes for cathepsin K inhibitors

Bioorganic & medicinal chemistry, 2008-04, Vol.18 (8), p.2599-2603

2008

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Discovery of selective and nonpeptidic cathepsin S inhibitors

Bioorganic & medicinal chemistry, 2008-07, Vol.18 (14), p.3959-3962

2008

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Overcoming hERG issues for brain-penetrating cathepsin S inhibitors: 2-Cyanopyrimidines. Part 2

Bioorganic & medicinal chemistry, 2008-10, Vol.18 (19), p.5280-5284

2008

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Asymmetric synthesis of the carbapenem antibiotic (+)-PS-5

Journal of organic chemistry, 1987-07, Vol.52 (15), p.3488-3489

1987

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4-Amino-2-cyanopyrimidines: Novel scaffold for nonpeptidic cathepsin S inhibitors

Bioorganic & medicinal chemistry letters, 2008-08, Vol.18 (16), p.4642-4646

2008

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A Practical and Diastereoselective Synthesis of Angiotensin Converting Enzyme Inhibitors

Chemical and Pharmaceutical Bulletin, 1989/02/25, Vol.37(2), pp.280-283

1989

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ChemInform Abstract: Asymmetric Synthesis of CP‐99,994 by Ring‐Expanding Amination of Monosubstituted Prolinols

ChemInform, 2016-06, Vol.47 (28), p.no-no

2016

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A Stereoselective Synthesis of N-[(S)-1-Ethoxycarbonyl-3-phenylpropyl]-L-alanine Derivatives by Means of Reductive Amination

Chemistry letters, 1988-10, Vol.17 (10), p.1691-1694

1988

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Facile Formation of 2,2'-Diquinolylmethane N,N'-Dioxides and Mono-N-oxides And Relateed Reactions

Heterocycles, 1984, Vol.22 (8), p.1811

1984

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Na, K-ATPase α3 is a death target of Alzheimer patient amyloid-β assembly

Synthesis and biological evaluation of quinones derived from natural product komaroviquinone as anti-Trypanosoma cruzi agents

化学反応に最適な酵素を予測するための機械学習を用いたEC番号予測モデルの開発

A novel derivative (GTN024) from a natural product, komaroviquinone, induced the apoptosis of high-risk myeloma cells via reactive oxygen production and ER stress

GTN057, a komaroviquinone derivative, induced myeloma cells' death in vivo and inhibited c‐MET tyrosine kinase

A short and efficient asymmetric synthesis of komaroviquinone

Synthesis and biological evaluation of the natural product komaroviquinone and related compounds aiming at a potential therapeutic lead compound for high-risk multiple myeloma

Effect of Cathepsin K Inhibitors on Bone Resorption

Development of EC number prediction model using machine learning to predict the optimal enzyme for a chemical reaction

Na, K-ATPase alpha 3 is a death target of Alzheimer patient amyloid- beta assembly

Komaroviquinone-Derivatives, Revealed Anti-Tumor Effect on High-Risk Multiple Myeloma Cells In Vitro as Well as In Vivo

Na, K-ATPase [Alpha]3 is a death target of Alzheimer patient amyloid-[Beta] assembly

A Novel Class of Herbicides: Specific Inhibitors of Imidazoleglycerol Phosphate Dehydratase

Discovery of Orally Bioavailable Cathepsin S Inhibitors for the Reversal of Neuropathic Pain

Novel scaffold for cathepsin K inhibitors

Synthesis of Inhibitors of Imidazole Glycerol Phosphate Dehydratase

New chemotypes for cathepsin K inhibitors

Discovery of selective and nonpeptidic cathepsin S inhibitors

Overcoming hERG issues for brain-penetrating cathepsin S inhibitors: 2-Cyanopyrimidines. Part 2

Asymmetric synthesis of the carbapenem antibiotic (+)-PS-5

4-Amino-2-cyanopyrimidines: Novel scaffold for nonpeptidic cathepsin S inhibitors

A Practical and Diastereoselective Synthesis of Angiotensin Converting Enzyme Inhibitors

ChemInform Abstract: Asymmetric Synthesis of CP‐99,994 by Ring‐Expanding Amination of Monosubstituted Prolinols

A Stereoselective Synthesis of N-[(S)-1-Ethoxycarbonyl-3-phenylpropyl]-L-alanine Derivatives by Means of Reductive Amination

Facile Formation of 2,2'-Diquinolylmethane N,N'-Dioxides and Mono-N-oxides And Relateed Reactions

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