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Amide-based atropisomers in tachykinin NK1-receptor antagonists: synthesis and antagonistic activity of axially chiral N-benzylcarboxamide derivatives of 2,3,4,5-tetrahydro-6H-pyrido[2,3-b][1,5]oxazocin-6-one

Tetrahedron, 2004-05, Vol.60 (20), p.4481-4490

2004

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Axially Chiral 1,7-Naphthyridine-6-carboxamide Derivatives as Orally Active Tachykinin NK1 Receptor Antagonists: Synthesis, Antagonistic Activity, and Effects on Bladder Functions

Journal of medicinal chemistry, 1999-09, Vol.42 (19), p.3982-3993

1999

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Discovery of 1,8-naphthyridin-2-one derivative as a potent and selective sphingomyelin synthase 2 inhibitor

Bioorganic & medicinal chemistry, 2020-04, Vol.28 (7), p.115376-115376, Article 115376

2020

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Effects of TAK-802, a novel acetylcholinesterase inhibitor, on distension-induced rhythmic bladder contractions in rats and guinea pigs

European journal of pharmacology, 2004-02, Vol.485 (1), p.299-305

2004

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Axially Chiral N-Benzyl-N,7-dimethyl-5-phenyl-1,7-naphthyridine-6-carboxamide Derivatives as Tachykinin NK1 Receptor Antagonists: Determination of the Absolute Stereochemical Requirements

Journal of medicinal chemistry, 1998-10, Vol.41 (22), p.4232-4239

1998

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Discovery of 4-chloro-2-(2,4-dichloro-6-methylphenoxy)-1-methyl-7-(pentan-3-yl)-1H-benzimidazole, a novel CRF1 receptor antagonist

Bioorganic & medicinal chemistry, 2017-03, Vol.25 (5), p.1556-1570

2017

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Design, synthesis, and biological evaluation of a novel series of peripheral-selective noradrenaline reuptake inhibitors – Part 3

Bioorganic & medicinal chemistry, 2016-08, Vol.24 (16), p.3716-3726

2016

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Intramolecular carbon-carbon bond formation by the anodic oxidation of unsaturated .alpha.-stannyl heteroatom compounds. Synthesis of fluorine containing heterocyclic compounds

Journal of the American Chemical Society, 1992-09, Vol.114 (19), p.7594-7595

1992

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Preparation of (S)-4-(1-(3,4-dichlorophenyl)-2-methoxyethyl)piperidine

Tetrahedron: asymmetry, 2015-09, Vol.26 (17), p.935-942

2015

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Novel, Potent, and Orally Active Substance P Antagonists: Synthesis and Antagonist Activity of N-Benzylcarboxamide Derivatives of Pyrido[3,4-b]pyridine

Journal of medicinal chemistry, 1995-08, Vol.38 (16), p.3106-3120

1995

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Design, synthesis, and biological evaluation of a novel series of peripheral-selective noradrenaline reuptake inhibitors—Part 2

Bioorganic & medicinal chemistry, 2016-07, Vol.24 (14), p.3207-3217

2016

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Design, synthesis and biological evaluation of a novel series of peripheral-selective noradrenaline reuptake inhibitor

Bioorganic & medicinal chemistry, 2015-08, Vol.23 (15), p.5000-5014

2015

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Design, synthesis, and biological activities of 1-aryl-1,4-diazepan-2-one derivatives as novel triple reuptake inhibitors

Bioorganic & medicinal chemistry letters, 2014-08, Vol.24 (16), p.3898-3902

2014

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Novel triple reuptake inhibitors with low risk of CAD associated liabilities: Design, synthesis and biological activities of 4-[(1S)-1-(3,4-dichlorophenyl)-2-methoxyethyl]piperidine and related compounds

Bioorganic & medicinal chemistry, 2013-08, Vol.21 (15), p.4600-4613

2013

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Discovery of 4-chloro-2-(2,4-dichloro-6-methylphenoxy)-1-methyl-7-(pentan-3-yl)-1H-benzimidazole, a novel CRF 1 receptor antagonist

Bioorganic & medicinal chemistry, 2017-03, Vol.25 (5), p.1556

2017

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Amide-based atropisomers in tachykinin NK 1-receptor antagonists: synthesis and antagonistic activity of axially chiral N-benzylcarboxamide derivatives of 2,3,4,5-tetrahydro-6 H-pyrido[2,3- b][1,5]oxazocin-6-one

Tetrahedron, 2004, Vol.60 (20), p.4481-4490

2004

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Novel acetylcholinesterase inhibitor as increasing agent on rhythmic bladder contractions: SAR of 8-{3-[1-(3-fluorobenzyl)piperidin-4-yl]propanoyl}-1,2,5,6-tetrahydro-4H-pyrrolo[ 3,2,1-ij]quinolin-4-one (TAK-802) and related compounds

Bioorganic & medicinal chemistry, 2005-03, Vol.13 (6), p.1901-1911

2005

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Novel acetylcholinesterase inhibitor as increasing agent on rhythmic bladder contractions: SAR of 8-{3-[1-(3-fluorobenzyl)piperidin-4-yl]propanoyl}-1,2,5,6-tetrahydro-4 H-pyrrolo[3,2,1- ij]quinolin-4-one (TAK-802) and related compounds

Bioorganic & medicinal chemistry, 2005, Vol.13 (6), p.1901-1911

2005

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Axially Chiral 1,7-Naphthyridine-6-carboxamide Derivatives as Orally Active Tachykinin NK 1 Receptor Antagonists: Synthesis, Antagonistic Activity, and Effects on Bladder Functions

Journal of medicinal chemistry, 1999-09, Vol.42 (19), p.3982-3993

1999

Volltextzugriff (PDF)

Axially Chiral N -Benzyl- N ,7-dimethyl-5-phenyl-1,7-naphthyridine-6-carboxamide Derivatives as Tachykinin NK 1 Receptor Antagonists: Determination of the Absolute Stereochemical Requirements

Journal of medicinal chemistry, 1998-10, Vol.41 (22), p.4232-4239

1998

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Electrochemical oxidation of α-alkoxystannanes

Tetrahedron letters, 1992-04, Vol.33 (18), p.2599-2602

1992

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Anodic oxidation of α-alkoxycarbonyloxy and α-acyloxy organotin compounds

Tetrahedron letters, 1994-07, Vol.35 (29), p.5247-5250

1994

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A new method for the synthesis of acylsilanes via one-carbon homologation of aldehydes

Journal of organic chemistry, 1991-02, Vol.56 (3), p.1307-1309

1991

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Electrochemical Oxidation of α-Alkoxygermanes and Acylgermanes

Synlett, 1992-10, Vol.1992 (10), p.843-844

1992

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Anodic cyclization of unsaturated α-stannyl ethers. Termination by bromide derived from dibromomethane

Journal of the Chemical Society. Chemical communications, 1994 (20), p.2361-2362

1994

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Amide-based atropisomers in tachykinin NK1-receptor antagonists: synthesis and antagonistic activity of axially chiral N-benzylcarboxamide derivatives of 2,3,4,5-tetrahydro-6H-pyrido[2,3-b][1,5]oxazocin-6-one

Axially Chiral 1,7-Naphthyridine-6-carboxamide Derivatives as Orally Active Tachykinin NK1 Receptor Antagonists: Synthesis, Antagonistic Activity, and Effects on Bladder Functions

Discovery of 1,8-naphthyridin-2-one derivative as a potent and selective sphingomyelin synthase 2 inhibitor

Effects of TAK-802, a novel acetylcholinesterase inhibitor, on distension-induced rhythmic bladder contractions in rats and guinea pigs

Axially Chiral N-Benzyl-N,7-dimethyl-5-phenyl-1,7-naphthyridine-6-carboxamide Derivatives as Tachykinin NK1 Receptor Antagonists: Determination of the Absolute Stereochemical Requirements

Discovery of 4-chloro-2-(2,4-dichloro-6-methylphenoxy)-1-methyl-7-(pentan-3-yl)-1H-benzimidazole, a novel CRF1 receptor antagonist

Design, synthesis, and biological evaluation of a novel series of peripheral-selective noradrenaline reuptake inhibitors – Part 3

Intramolecular carbon-carbon bond formation by the anodic oxidation of unsaturated .alpha.-stannyl heteroatom compounds. Synthesis of fluorine containing heterocyclic compounds

Preparation of (S)-4-(1-(3,4-dichlorophenyl)-2-methoxyethyl)piperidine

Novel, Potent, and Orally Active Substance P Antagonists: Synthesis and Antagonist Activity of N-Benzylcarboxamide Derivatives of Pyrido[3,4-b]pyridine

Design, synthesis, and biological evaluation of a novel series of peripheral-selective noradrenaline reuptake inhibitors—Part 2

Design, synthesis and biological evaluation of a novel series of peripheral-selective noradrenaline reuptake inhibitor

Design, synthesis, and biological activities of 1-aryl-1,4-diazepan-2-one derivatives as novel triple reuptake inhibitors

Novel triple reuptake inhibitors with low risk of CAD associated liabilities: Design, synthesis and biological activities of 4-[(1S)-1-(3,4-dichlorophenyl)-2-methoxyethyl]piperidine and related compounds

Discovery of 4-chloro-2-(2,4-dichloro-6-methylphenoxy)-1-methyl-7-(pentan-3-yl)-1H-benzimidazole, a novel CRF 1 receptor antagonist

Amide-based atropisomers in tachykinin NK 1-receptor antagonists: synthesis and antagonistic activity of axially chiral N-benzylcarboxamide derivatives of 2,3,4,5-tetrahydro-6 H-pyrido[2,3- b][1,5]oxazocin-6-one

Novel acetylcholinesterase inhibitor as increasing agent on rhythmic bladder contractions: SAR of 8-{3-[1-(3-fluorobenzyl)piperidin-4-yl]propanoyl}-1,2,5,6-tetrahydro-4H-pyrrolo[ 3,2,1-ij]quinolin-4-one (TAK-802) and related compounds

Novel acetylcholinesterase inhibitor as increasing agent on rhythmic bladder contractions: SAR of 8-{3-[1-(3-fluorobenzyl)piperidin-4-yl]propanoyl}-1,2,5,6-tetrahydro-4 H-pyrrolo[3,2,1- ij]quinolin-4-one (TAK-802) and related compounds

Axially Chiral 1,7-Naphthyridine-6-carboxamide Derivatives as Orally Active Tachykinin NK 1 Receptor Antagonists: Synthesis, Antagonistic Activity, and Effects on Bladder Functions

Axially Chiral N -Benzyl- N ,7-dimethyl-5-phenyl-1,7-naphthyridine-6-carboxamide Derivatives as Tachykinin NK 1 Receptor Antagonists: Determination of the Absolute Stereochemical Requirements

Electrochemical oxidation of α-alkoxystannanes

Anodic oxidation of α-alkoxycarbonyloxy and α-acyloxy organotin compounds

A new method for the synthesis of acylsilanes via one-carbon homologation of aldehydes

Electrochemical Oxidation of α-Alkoxygermanes and Acylgermanes

Anodic cyclization of unsaturated α-stannyl ethers. Termination by bromide derived from dibromomethane

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