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The role of TREM2 N-glycans in trafficking to the cell surface and signal transduction of TREM2

Journal of biochemistry (Tokyo), 2022-12, Vol.172 (6), p.347-353

2022

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Meet Our Regional Editor

Current neuropharmacology, 2018-01, Vol.16 (1), p.1-1

Iwata, Nobuhisa

2018

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iPSC-Based Compound Screening and In Vitro Trials Identify a Synergistic Anti-amyloid β Combination for Alzheimer’s Disease

Cell reports (Cambridge), 2017-11, Vol.21 (8), p.2304-2312

2017

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Aβ Secretion and Plaque Formation Depend on Autophagy

Cell reports (Cambridge), 2013-10, Vol.5 (1), p.61-69

2013

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Enhancement of Neprilysin Activity by Natural Polyphenolic Compounds and Their Derivatives in Cultured Neuroglioma Cells

Biological and Pharmaceutical Bulletin, 2023/03/01, Vol.46(3), pp.446-454

2023

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Neprilysin Is Suppressed by Dual-Specificity Tyrosine-Phosphorylation Regulated Kinase 1A (DYRK1A) in Down-Syndrome-Derived Fibroblasts

Biological and Pharmaceutical Bulletin, 2017/03/01, Vol.40(3), pp.327-333

2017

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Imaging of Tau Pathology in a Tauopathy Mouse Model and in Alzheimer Patients Compared to Normal Controls

Neuron (Cambridge, Mass.), 2013-09, Vol.79 (6), p.1094-1108

2013

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Activity‐dependent cleavage of dyskinesia‐related proline‐rich transmembrane protein 2 (PRRT2) by calpain in mouse primary cortical neurons

The FASEB journal, 2020-01, Vol.34 (1), p.180-191

2020

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Recent Advances in the Modeling of Alzheimer's Disease

Frontiers in neuroscience, 2022-03, Vol.16, p.807473

2022

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An aberrant sugar modification of BACE1 blocks its lysosomal targeting in Alzheimer's disease

EMBO molecular medicine, 2015-02, Vol.7 (2), p.175-189

2015

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Identification and Characterization of Synaptic Vesicle Membrane Protein VAT-1 Homolog as a New Catechin-Binding Protein

Biological and Pharmaceutical Bulletin, 2024/02/23, Vol.47(2), pp.509-517

2024

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Synapse Loss and Microglial Activation Precede Tangles in a P301S Tauopathy Mouse Model

Neuron (Cambridge, Mass.), 2007-02, Vol.53 (3), p.337-351

2007

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A role for calpain-dependent cleavage of TDP-43 in amyotrophic lateral sclerosis pathology

Nature communications, 2012-12, Vol.3 (1), p.1307-1307, Article 1307

2012

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Alterations of ATG4A and LC3B in neurons derived from Alzheimer's disease patients

Genes to cells : devoted to molecular & cellular mechanisms, 2023-04, Vol.28 (4), p.319-325

2023

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Anti-Aβ drug screening platform using human iPS cell-derived neurons for the treatment of Alzheimer's disease

PloS one, 2011-09, Vol.6 (9), p.e25788

2011

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Proline-rich transmembrane protein 2 knock-in mice present dopamine-dependent motor deficits

Journal of biochemistry (Tokyo), 2023-11, Vol.174 (6), p.561-570

2023

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A simplified and sensitive method to identify Alzheimer's disease biomarker candidates using patient-derived induced pluripotent stem cells (iPSCs)

Journal of biochemistry (Tokyo), 2017-12, Vol.162 (6), p.391-394

2017

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Longitudinal, Quantitative Assessment of Amyloid, Neuroinflammation, and Anti-Amyloid Treatment in a Living Mouse Model of Alzheimer's Disease Enabled by Positron Emission Tomography

The Journal of neuroscience, 2007-10, Vol.27 (41), p.10957-10968

2007

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Paradigm shift from diagnosing patients based on common symptoms to categorizing patients into subtypes with different pathogenic mechanisms to guide treatment for Alzheimer's disease

Journal of biochemistry (Tokyo), 2017-06, Vol.161 (6), p.463-470

2017

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Local Action of Neprilysin Exacerbates Pressure Overload Induced Cardiac Remodeling

Hypertension (Dallas, Tex. 1979), 2021-06, Vol.77 (6), p.1931-1939

2021

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Global brain delivery of neprilysin gene by intravascular administration of AAV vector in mice

Scientific reports, 2013-03, Vol.3 (1), p.1472-1472, Article 1472

2013

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Perturbed Calcineurin-NFAT Signaling Is Associated with the Development of Alzheimer’s Disease

Biological and Pharmaceutical Bulletin, 2016/10/01, Vol.39(10), pp.1646-1652

2016

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Mechanistic involvement of the calpain‐calpastatin system in Alzheimer neuropathology

The FASEB journal, 2012-03, Vol.26 (3), p.1204-1217

2012

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Metabolism of amyloid beta peptide and pathogenesis of Alzheimer's disease. Towards presymptomatic diagnosis, prevention and therapy

Neuroscience research, 2006-04, Vol.54 (4), p.235-253

2006

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Loss of neprilysin alters protein expression in the brain of Alzheimer's disease model mice

Proteomics (Weinheim), 2015-10, Vol.15 (19), p.3349-3355

2015

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The role of TREM2 N-glycans in trafficking to the cell surface and signal transduction of TREM2

Meet Our Regional Editor

iPSC-Based Compound Screening and In Vitro Trials Identify a Synergistic Anti-amyloid β Combination for Alzheimer’s Disease

Aβ Secretion and Plaque Formation Depend on Autophagy

Enhancement of Neprilysin Activity by Natural Polyphenolic Compounds and Their Derivatives in Cultured Neuroglioma Cells

Neprilysin Is Suppressed by Dual-Specificity Tyrosine-Phosphorylation Regulated Kinase 1A (DYRK1A) in Down-Syndrome-Derived Fibroblasts

Imaging of Tau Pathology in a Tauopathy Mouse Model and in Alzheimer Patients Compared to Normal Controls

Activity‐dependent cleavage of dyskinesia‐related proline‐rich transmembrane protein 2 (PRRT2) by calpain in mouse primary cortical neurons

Recent Advances in the Modeling of Alzheimer's Disease

An aberrant sugar modification of BACE1 blocks its lysosomal targeting in Alzheimer's disease

Identification and Characterization of Synaptic Vesicle Membrane Protein VAT-1 Homolog as a New Catechin-Binding Protein

Synapse Loss and Microglial Activation Precede Tangles in a P301S Tauopathy Mouse Model

A role for calpain-dependent cleavage of TDP-43 in amyotrophic lateral sclerosis pathology

Alterations of ATG4A and LC3B in neurons derived from Alzheimer's disease patients

Anti-Aβ drug screening platform using human iPS cell-derived neurons for the treatment of Alzheimer's disease

Proline-rich transmembrane protein 2 knock-in mice present dopamine-dependent motor deficits

A simplified and sensitive method to identify Alzheimer's disease biomarker candidates using patient-derived induced pluripotent stem cells (iPSCs)

Longitudinal, Quantitative Assessment of Amyloid, Neuroinflammation, and Anti-Amyloid Treatment in a Living Mouse Model of Alzheimer's Disease Enabled by Positron Emission Tomography

Paradigm shift from diagnosing patients based on common symptoms to categorizing patients into subtypes with different pathogenic mechanisms to guide treatment for Alzheimer's disease

Local Action of Neprilysin Exacerbates Pressure Overload Induced Cardiac Remodeling

Global brain delivery of neprilysin gene by intravascular administration of AAV vector in mice

Perturbed Calcineurin-NFAT Signaling Is Associated with the Development of Alzheimer’s Disease

Mechanistic involvement of the calpain‐calpastatin system in Alzheimer neuropathology

Metabolism of amyloid beta peptide and pathogenesis of Alzheimer's disease. Towards presymptomatic diagnosis, prevention and therapy

Loss of neprilysin alters protein expression in the brain of Alzheimer's disease model mice

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