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Identification of Optimal Drug Combinations Targeting Cellular Networks: Integrating Phospho-Proteomics and Computational Network Analysis

Cancer research (Chicago, Ill.), 2010-09, Vol.70 (17), p.6704-6714

2010

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Dual Inhibition of IGF-1R and ErbB3 Enhances the Activity of Gemcitabine and Nab-Paclitaxel in Preclinical Models of Pancreatic Cancer

Clinical cancer research, 2018-06, Vol.24 (12), p.2873-2885

2018

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A mechanistic pharmacokinetic model for intrathecal administration of antisense oligonucleotides

Frontiers in physiology, 2023-06, Vol.14, p.1130925-1130925

2023

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Understanding the role of cross-arm binding efficiency in the activity of monoclonal and multispecific therapeutic antibodies

Methods (San Diego, Calif.), 2014-01, Vol.65 (1), p.95-104

2014

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Proteomic Characterization of Breast Cancer Xenografts Identifies Early and Late Bevacizumab-Induced Responses and Predicts Effective Drug Combinations

Clinical cancer research, 2014-01, Vol.20 (2), p.404-412

2014

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Abstract 4920: Integrative identification of stochastically activated signaling sub-networks in individual cancer cells

Cancer research (Chicago, Ill.), 2011-04, Vol.71 (8_Supplement), p.4920-4920

2011

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Mapping network motif tunability and robustness in the design of synthetic signaling circuits

PloS one, 2014-03, Vol.9 (3), p.e91743-e91743

2014

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Abstract C169: MM-141, a bispecific antibody inhibitor of PI3K/AKT/mTOR, attenuates tumor growth and potentiates everolimus in mouse models of anti-hormonal therapy-resistant ER/PR+ breast cancer

Molecular cancer therapeutics, 2013-11, Vol.12 (11_Supplement), p.C169-C169

2013

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MM-141, an IGF-IR- and ErbB3-directed bispecific antibody, overcomes network adaptations that limit activity of IGF-IR inhibitors

Molecular cancer therapeutics, 2014-02, Vol.13 (2), p.410-425

2014

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Dual targeting of IGF-1R and ErbB3 as a potential therapeutic regimen for ovarian cancer

Scientific reports, 2019-11, Vol.9 (1), p.16832-10, Article 16832

2019

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Abstract 1209: Istiratumab (MM-141), a bispecific antibody targeting IGF-1R and ErbB3, inhibits pro-survival signaling in vitro and potentiates the activity of standard of care chemotherapy in vivo in ovarian cancer models

Cancer research (Chicago, Ill.), 2016-07, Vol.76 (14_Supplement), p.1209-1209

2016

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Kinome siRNA-phosphoproteomic screen identifies networks regulating AKT signaling

Oncogene, 2011-11, Vol.30 (45), p.4567-4577

2011

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Abstract LB-243: The ErbB3-targeting antibody MM-121 (seribantumab) reverses heregulin-driven resistance to multiple chemotherapies on tumor cell growth

Cancer research (Chicago, Ill.), 2015-08, Vol.75 (15_Supplement), p.LB-243-LB-243

2015

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Abstract A89: Istiratumab (MM-141), a bispecific antibody co-targeting IGF-1R and ErbB3, potentiates the activity of immune checkpoint inhibitors

Molecular cancer therapeutics, 2015-12, Vol.14 (12_Supplement_2), p.A89-A89

2015

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Effect of MM-141 on gemcitabine and nab-paclitaxel potentiation in preclinical models of pancreatic cancer through induction of IGF-1R and ErbB3 degradation

Journal of clinical oncology, 2015-01, Vol.33 (3_suppl), p.289-289

2015

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Abstract CT237: Preclinical characterization and first-in-human study of MM-141, a dual antibody inhibitor of IGF-1R and ErbB3

Cancer research (Chicago, Ill.), 2015-08, Vol.75 (15_Supplement), p.CT237-CT237

2015

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Phosphoproteomics and mass-action modeling to predict optimal drug combination in signaling networks

Clinical cancer research, 2010-10, Vol.16 (19_Supplement), p.B32-B32

2010

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Genetic network driven control of PHBV copolymer composition

Journal of biotechnology, 2006-03, Vol.122 (1), p.99-121

2006

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Synthesis of PHBV block copolymers driven by an oscillatory genetic network

Journal of biotechnology, 2007-02, Vol.128 (3), p.615-637

2007

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Environmentally-modulated changes in fluorescence distribution in cells with oscillatory genetic network dynamics

Journal of biotechnology, 2009-03, Vol.140 (3-4), p.203-217

2009

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Design of artificial genetic networks to regulate the biosynthesis of polyhydroxyalkanoate copolymers with desirable structures

Iadevaia, Sergio

2008

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Design of artificial genetic networks to regulate the biosynthesis of polyhydroxyalkanoate copolymers with desirable structures

Iadevaia, Sergio

2008

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Identification of Optimal Drug Combinations Targeting Cellular Networks: Integrating Phospho-Proteomics and Computational Network Analysis

Dual Inhibition of IGF-1R and ErbB3 Enhances the Activity of Gemcitabine and Nab-Paclitaxel in Preclinical Models of Pancreatic Cancer

A mechanistic pharmacokinetic model for intrathecal administration of antisense oligonucleotides

Understanding the role of cross-arm binding efficiency in the activity of monoclonal and multispecific therapeutic antibodies

Proteomic Characterization of Breast Cancer Xenografts Identifies Early and Late Bevacizumab-Induced Responses and Predicts Effective Drug Combinations

Abstract 4920: Integrative identification of stochastically activated signaling sub-networks in individual cancer cells

Mapping network motif tunability and robustness in the design of synthetic signaling circuits

Abstract C169: MM-141, a bispecific antibody inhibitor of PI3K/AKT/mTOR, attenuates tumor growth and potentiates everolimus in mouse models of anti-hormonal therapy-resistant ER/PR+ breast cancer

MM-141, an IGF-IR- and ErbB3-directed bispecific antibody, overcomes network adaptations that limit activity of IGF-IR inhibitors

Dual targeting of IGF-1R and ErbB3 as a potential therapeutic regimen for ovarian cancer

Abstract 1209: Istiratumab (MM-141), a bispecific antibody targeting IGF-1R and ErbB3, inhibits pro-survival signaling in vitro and potentiates the activity of standard of care chemotherapy in vivo in ovarian cancer models

Kinome siRNA-phosphoproteomic screen identifies networks regulating AKT signaling

Abstract LB-243: The ErbB3-targeting antibody MM-121 (seribantumab) reverses heregulin-driven resistance to multiple chemotherapies on tumor cell growth

Abstract A89: Istiratumab (MM-141), a bispecific antibody co-targeting IGF-1R and ErbB3, potentiates the activity of immune checkpoint inhibitors

Effect of MM-141 on gemcitabine and nab-paclitaxel potentiation in preclinical models of pancreatic cancer through induction of IGF-1R and ErbB3 degradation

Abstract CT237: Preclinical characterization and first-in-human study of MM-141, a dual antibody inhibitor of IGF-1R and ErbB3

Phosphoproteomics and mass-action modeling to predict optimal drug combination in signaling networks

Genetic network driven control of PHBV copolymer composition

Synthesis of PHBV block copolymers driven by an oscillatory genetic network

Environmentally-modulated changes in fluorescence distribution in cells with oscillatory genetic network dynamics

Design of artificial genetic networks to regulate the biosynthesis of polyhydroxyalkanoate copolymers with desirable structures

Design of artificial genetic networks to regulate the biosynthesis of polyhydroxyalkanoate copolymers with desirable structures

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