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Cytochrome P450 3A4 is the major enzyme involved in the metabolism of the substance P receptor antagonist aprepitant

Drug metabolism and disposition, 2004-11, Vol.32 (11), p.1287

2004

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KAE609 (Cipargamin), a New Spiroindolone Agent for the Treatment of Malaria: Evaluation of the Absorption, Distribution, Metabolism, and Excretion of a Single Oral 300-mg Dose of [14C]KAE609 in Healthy Male Subjects

Drug metabolism and disposition, 2016-05, Vol.44 (5), p.672-682

2016

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Activators of the Rat Pregnane X Receptor Differentially Modulate Hepatic and Intestinal Gene Expression

Molecular pharmacology, 2004-05, Vol.65 (5), p.1159-1171

2004

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Utilization of Stable Isotope Labeling to Facilitate the Identification of Polar Metabolites of KAF156, an Antimalarial Agent

Drug metabolism and disposition, 2016-10, Vol.44 (10), p.1697-1708

2016

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Identification of Three Novel Ring Expansion Metabolites of KAE609, a New Spiroindolone Agent for the Treatment of Malaria, in Rats, Dogs, and Humans

Drug metabolism and disposition, 2016-05, Vol.44 (5), p.653-664

2016

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The involvement of CYP3A4 and CYP2C9 in the metabolism of 17 alpha-ethinylestradiol

Drug metabolism and disposition, 2004-11, Vol.32 (11), p.1209

2004

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An industry perspective on tiered approach to the investigation of metabolites in drug development

Bioanalysis, 2014-03, Vol.6 (5), p.617-628

2014

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Brain penetration of aprepitant, a substance P receptor antagonist, in ferrets

Drug metabolism and disposition, 2003-06, Vol.31 (6), p.785

2003

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The metabolic disposition of aprepitant, a substance P receptor antagonist, in rats and dogs

Drug metabolism and disposition, 2004-02, Vol.32 (2), p.246

2004

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Application of LC–NMR for the study of the volatile metabolite of MK-0869, a substance P receptor antagonist

Journal of pharmaceutical and biomedical analysis, 2003, Vol.30 (5), p.1431-1440

2003

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Phosphorylated Morpholine Acetal Human Neurokinin-1 Receptor Antagonists as Water-Soluble Prodrugs

Journal of medicinal chemistry, 2000-03, Vol.43 (6), p.1234-1241

2000

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Effect of impaired renal function and haemodialysis on the pharmacokinetics of aprepitant

Clinical pharmacokinetics, 2005-01, Vol.44 (6), p.637-647

2005

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Species differences in N-glucuronidation

Drug metabolism and disposition, 1998-09, Vol.26 (9), p.838

1998

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Substance P receptor antagonist I: conversion of phosphoramidate prodrug after i.v. administration to rats and dogs

Drug metabolism and disposition, 1999-11, Vol.27 (11), p.1367

1999

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Expression in Escherichia coli of rat liver cytosolic glutathione S-transferase Yc cDNA

Archives of biochemistry and biophysics, 1990-05, Vol.279 (1), p.116-121

1990

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Contributions of thiolate "desolvation" to catalysis by glutathione S-transferase isozymes 1-1 and 2-2: evidence from kinetic solvent isotope effects

Journal of the American Chemical Society, 1991-03, Vol.113 (6), p.2283-2290

1991

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The Role of Drug Metabolism in Drug Discovery: A Case Study in the Selection of an Oxytocin Receptor Antagonist for Development

Toxicologic pathology, 1995-03, Vol.23 (2), p.124-130

1995

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Site-directed mutagenesis of glutathione S-transferase YaYa. Important roles of tyrosine 9 and aspartic acid 101 in catalysis

The Journal of biological chemistry, 1992-10, Vol.267 (28), p.19866-19871

1992

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Potent, orally bioavailable somatostatin agonists: Good absorption achieved by urea backbone cyclization

Bioorganic & medicinal chemistry letters, 1999-02, Vol.9 (3), p.491-496

1999

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Chiral instability at sulfur of S-adenosylmethionine

Biochemistry (Easton), 1983-06, Vol.22 (12), p.2828-2832

1983

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Different isotope effects for parallel pathways of enzyme-catalyzed transmethylation

Journal of the American Chemical Society, 1984-09, Vol.106 (19), p.5762-5763

1984

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Cytochrome P450 3A4 is the major enzyme involved in the metabolism of the substance P receptor antagonist aprepitant

KAE609 (Cipargamin), a New Spiroindolone Agent for the Treatment of Malaria: Evaluation of the Absorption, Distribution, Metabolism, and Excretion of a Single Oral 300-mg Dose of [14C]KAE609 in Healthy Male Subjects

Activators of the Rat Pregnane X Receptor Differentially Modulate Hepatic and Intestinal Gene Expression

Utilization of Stable Isotope Labeling to Facilitate the Identification of Polar Metabolites of KAF156, an Antimalarial Agent

Identification of Three Novel Ring Expansion Metabolites of KAE609, a New Spiroindolone Agent for the Treatment of Malaria, in Rats, Dogs, and Humans

The involvement of CYP3A4 and CYP2C9 in the metabolism of 17 alpha-ethinylestradiol

An industry perspective on tiered approach to the investigation of metabolites in drug development

Brain penetration of aprepitant, a substance P receptor antagonist, in ferrets

The metabolic disposition of aprepitant, a substance P receptor antagonist, in rats and dogs

Application of LC–NMR for the study of the volatile metabolite of MK-0869, a substance P receptor antagonist

Phosphorylated Morpholine Acetal Human Neurokinin-1 Receptor Antagonists as Water-Soluble Prodrugs

Effect of impaired renal function and haemodialysis on the pharmacokinetics of aprepitant

Species differences in N-glucuronidation

Substance P receptor antagonist I: conversion of phosphoramidate prodrug after i.v. administration to rats and dogs

Expression in Escherichia coli of rat liver cytosolic glutathione S-transferase Yc cDNA

Contributions of thiolate "desolvation" to catalysis by glutathione S-transferase isozymes 1-1 and 2-2: evidence from kinetic solvent isotope effects

The Role of Drug Metabolism in Drug Discovery: A Case Study in the Selection of an Oxytocin Receptor Antagonist for Development

Site-directed mutagenesis of glutathione S-transferase YaYa. Important roles of tyrosine 9 and aspartic acid 101 in catalysis

Potent, orally bioavailable somatostatin agonists: Good absorption achieved by urea backbone cyclization

Chiral instability at sulfur of S-adenosylmethionine

Different isotope effects for parallel pathways of enzyme-catalyzed transmethylation

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