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Aurora kinase A inhibitor, LY3295668 erbumine: a phase 1 monotherapy safety study in patients with locally advanced or metastatic solid tumors

Investigational new drugs, 2021-08, Vol.39 (4), p.1001-1010

2021

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Discovery of a Highly Selective NAMPT Inhibitor That Demonstrates Robust Efficacy and Improved Retinal Toxicity with Nicotinic Acid Coadministration

Molecular cancer therapeutics, 2017-12, Vol.16 (12), p.2677-2688

2017

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Characterization of a novel AICARFT inhibitor which potently elevates ZMP and has anti-tumor activity in murine models

Scientific reports, 2018-10, Vol.8 (1), p.15458-12, Article 15458

2018

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Evaluation and Optimization of Blood Micro-Sampling Methods: Serial Sampling in a Cross-Over Design from an Individual Mouse

Journal of pharmacy & pharmaceutical sciences, 2016-10, Vol.19 (4), p.496

2016

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Identification of LY2510924, a novel cyclic peptide CXCR4 antagonist that exhibits antitumor activities in solid tumor and breast cancer metastatic models

Molecular cancer therapeutics, 2015-02, Vol.14 (2), p.480-490

2015

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An evaluation of metabolite profiling of six drugs using dried blood spot

Xenobiotica, 2019-12, Vol.49 (12), p.1458-1469

2019

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Angiopoietin-like protein 8 deficiency attenuates thoracic aortic aneurysm/dissection development in β-aminopropionitrile monofumarate-induced model mice

Biochimica et biophysica acta. Molecular basis of disease, 2023-02, Vol.1869 (2), p.166619, Article 166619

2023

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Metabolite profiling using dried blood spot

Drug metabolism and pharmacokinetics, 2019-01, Vol.34 (1), p.S58-S58

2019

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Angiopoietin-like proteins 8 knockout reduces intermittent hypoxia-induced vascular remodeling in a murine model of obstructive sleep apnea

Biochemical pharmacology, 2021-04, Vol.186, p.114502-114502, Article 114502

2021

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Aurora A-Selective Inhibitor LY3295668 Leads to Dominant Mitotic Arrest, Apoptosis in Cancer Cells, and Shows Potent Preclinical Antitumor Efficacy

Molecular cancer therapeutics, 2019-12, Vol.18 (12), p.2207-2219

2019

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LY2801653 is an orally bioavailable multi-kinase inhibitor with potent activity against MET, MST1R, and other oncoproteins, and displays anti-tumor activities in mouse xenograft models

Investigational new drugs, 2013-08, Vol.31 (4), p.833-844

2013

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In Vitro and In Vivo Correlation of Hepatic Fraction of Metabolism by P450 in Dogs

Journal of pharmaceutical sciences, 2019-02, Vol.108 (2), p.1017-1026

2019

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Ring-Opening Polymeric Single-Crystal-to-Single-Crystal Transformation in a Co(II) Compound

Crystal growth & design, 2018-02, Vol.18 (2), p.587-591

2018

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P57 - Application of an abbreviated radiolabeled ADME study utilizing 3H-labeled test article in the transition between discovery and development

Drug metabolism and pharmacokinetics, 2020, Vol.35 (1), p.S39-S39

2020

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Genetic diversity and relationship of endangered plant Magnolia officinalis (Magnoliaceae) assessed with ISSR polymorphisms

Biochemical systematics and ecology, 2011-04, Vol.39 (2), p.71-78

2011

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Aurora A kinase inhibition induces accumulation of SCLC tumor cells in mitosis with restored interferon signaling to increase response to PD-L1

Cell reports. Medicine, 2023-11, Vol.4 (11), p.101282, Article 101282

2023

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Proteomic analysis of rat liver phosphoproteins after treatment with protein kinase inhibitor H89 (N-(2-[p-bromocinnamylamino-]ethyl)-5-isoquinolinesulfonamide)

The Journal of pharmacology and experimental therapeutics, 2006-08, Vol.318 (2), p.589-595

2006

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Potent, Orally Active Heterocycle-Based Combretastatin A-4 Analogues: Synthesis, Structure−Activity Relationship, Pharmacokinetics, and In Vivo Antitumor Activity Evaluation

Journal of medicinal chemistry, 2002-04, Vol.45 (8), p.1697-1711

2002

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Annonaceous Acetogenins: A Review

Journal of natural products (Washington, D.C.), 1990-03, Vol.53 (2), p.237-278

1990

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Pharmacokinetic comparisons of tail-bleeding with cannula- or retro-orbital bleeding techniques in rats using six marketed drugs

Journal of pharmacological and toxicological methods, 2007-09, Vol.56 (2), p.256-264

2007

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Discovery, SAR, synthesis, pharmacokinetic and biochemical characterization of A-192411: A novel fungicidal lipopeptide-(I)

Bioorganic & medicinal chemistry letters, 2003-02, Vol.13 (3), p.489-493

2003

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Synthesis and Biological Evaluation of 2-Indolyloxazolines as a New Class of Tubulin Polymerization Inhibitors. Discovery of A-289099 as an Orally Active Antitumor Agent

Bioorganic & medicinal chemistry letters, 2002-02, Vol.12 (3), p.465-469

2002

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Long-term propagation of tree shrew spermatogonial stem cells in culture and successful generation of transgenic offspring

Cell research, 2017-02, Vol.27 (2), p.241-252

2017

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Aurora kinase A inhibitor, LY3295668 erbumine: a phase 1 monotherapy safety study in patients with locally advanced or metastatic solid tumors

Discovery of a Highly Selective NAMPT Inhibitor That Demonstrates Robust Efficacy and Improved Retinal Toxicity with Nicotinic Acid Coadministration

Characterization of a novel AICARFT inhibitor which potently elevates ZMP and has anti-tumor activity in murine models

Aurora A Kinase Inhibition Is Synthetic Lethal with Loss of the RB1 Tumor Suppressor Gene

Evaluation and Optimization of Blood Micro-Sampling Methods: Serial Sampling in a Cross-Over Design from an Individual Mouse

Identification of LY2510924, a novel cyclic peptide CXCR4 antagonist that exhibits antitumor activities in solid tumor and breast cancer metastatic models

An evaluation of metabolite profiling of six drugs using dried blood spot

Angiopoietin-like protein 8 deficiency attenuates thoracic aortic aneurysm/dissection development in β-aminopropionitrile monofumarate-induced model mice

Metabolite profiling using dried blood spot

Angiopoietin-like proteins 8 knockout reduces intermittent hypoxia-induced vascular remodeling in a murine model of obstructive sleep apnea

Aurora A-Selective Inhibitor LY3295668 Leads to Dominant Mitotic Arrest, Apoptosis in Cancer Cells, and Shows Potent Preclinical Antitumor Efficacy

LY2801653 is an orally bioavailable multi-kinase inhibitor with potent activity against MET, MST1R, and other oncoproteins, and displays anti-tumor activities in mouse xenograft models

In Vitro and In Vivo Correlation of Hepatic Fraction of Metabolism by P450 in Dogs

Ring-Opening Polymeric Single-Crystal-to-Single-Crystal Transformation in a Co(II) Compound

P57 - Application of an abbreviated radiolabeled ADME study utilizing 3H-labeled test article in the transition between discovery and development

Genetic diversity and relationship of endangered plant Magnolia officinalis (Magnoliaceae) assessed with ISSR polymorphisms

Aurora A kinase inhibition induces accumulation of SCLC tumor cells in mitosis with restored interferon signaling to increase response to PD-L1

Proteomic analysis of rat liver phosphoproteins after treatment with protein kinase inhibitor H89 (N-(2-[p-bromocinnamylamino-]ethyl)-5-isoquinolinesulfonamide)

Potent, Orally Active Heterocycle-Based Combretastatin A-4 Analogues: Synthesis, Structure−Activity Relationship, Pharmacokinetics, and In Vivo Antitumor Activity Evaluation

Annonaceous Acetogenins: A Review

Pharmacokinetic comparisons of tail-bleeding with cannula- or retro-orbital bleeding techniques in rats using six marketed drugs

Discovery, SAR, synthesis, pharmacokinetic and biochemical characterization of A-192411: A novel fungicidal lipopeptide-(I)

Synthesis and Biological Evaluation of 2-Indolyloxazolines as a New Class of Tubulin Polymerization Inhibitors. Discovery of A-289099 as an Orally Active Antitumor Agent

Long-term propagation of tree shrew spermatogonial stem cells in culture and successful generation of transgenic offspring

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