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An intramolecular coupling approach to alkyl bioisosteres for the synthesis of multisubstituted bicycloalkyl boronates

Nature chemistry, 2021-10, Vol.13 (10), p.950-955

2021

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Aminoalkylation of [1.1.1]Propellane Enables Direct Access to High-Value 3‑Alkylbicyclo[1.1.1]pentan-1-amines

Organic letters, 2019-09, Vol.21 (17), p.6800-6804

2019

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Enantioenriched BCP Benzylamine Synthesis via Metal Hydride Hydrogen Atom Transfer/Sulfinimine Addition to [1.1.1]Propellane

Organic letters, 2022-01, Vol.24 (1), p.110-114

2022

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Desulfonylative Arylation of Redox-Active Alkyl Sulfones with Aryl Bromides

Organic letters, 2019-07, Vol.21 (14), p.5650-5654

2019

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Continuous Flow-Enabled Synthesis of Bench-Stable Bicyclo[1.1.1]pentane Trifluoroborate Salts and Their Utilization in Metallaphotoredox Cross-Couplings

Organic letters, 2020-02, Vol.22 (4), p.1648-1654

2020

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A Concise Enantioselective Total Synthesis of (−)‐Virosaine A

Angewandte Chemie International Edition, 2017-08, Vol.56 (36), p.10830-10834

2017

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Strain-release 2-azaallyl anion addition/borylation of [1.1.1]propellane: synthesis and functionalization of benzylamine bicyclo[1.1.1]pentyl boronates

Chemical science (Cambridge), 2021-04, Vol.12 (2), p.766-772

2021

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Alkyl sulfinates as cross-coupling partners for programmable and stereospecific installation of C(sp3) bioisosteres

Nature chemistry, 2023-04, Vol.15 (4), p.550-559

2023

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Programmable late-stage functionalization of bridge-substituted bicyclo[1.1.1]pentane bis-boronates

Nature chemistry, 2024-02, Vol.16 (2), p.285-293

2024

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Synthesis of α‑Aryl Secondary Amides via Nickel-Catalyzed Reductive Coupling of Redox-Active Esters

Organic letters, 2022-05, Vol.24 (17), p.3173-3178

2022

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Practical and Modular Construction of C(sp 3 )-Rich Alkyl Boron Compounds

Journal of the American Chemical Society, 2021-01, Vol.143 (1), p.471-480

2021

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Uncanonical Semireduction of Quinolines and Isoquinolines via Regioselective HAT-Promoted Hydrosilylation

Journal of the American Chemical Society, 2023-01, Vol.145 (1), p.25-31

2023

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Asymmetric Synthesis of Tertiary and Secondary Cyclopropyl Boronates via Cyclopropanation of Enantioenriched Alkenyl Boronic Esters

Organic letters, 2022-05, Vol.24 (19), p.3455-3460

2022

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Nickel-Catalyzed Reductive Arylation of Redox Active Esters for the Synthesis of α-Aryl Nitriles: Investigation of a Chlorosilane Additive

Journal of organic chemistry, 2024-01

2024

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Cerastecin Inhibition of the Lipooligosaccharide Transporter MsbA to Combat Acinetobacter baumannii : From Screening Impurity to In Vivo Efficacy

Journal of medicinal chemistry, 2024-09, Vol.67 (17), p.15620-15675

2024

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A Concise Enantioselective Total Synthesis of (-)-VirosaineA

Angewandte Chemie International Edition, 2017-08, Vol.56 (36), p.10830

International ed. in English, 2017

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Intramolecular Coupling for General Synthesis of Backbone Substituted Bicyclo[1.1.1]pentyl Boronates

Organic syntheses, 2024, Vol.101, p.181-206

Tsien, Jet

2024

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Organocatalytic Michael Addition of Indoles to α‐Substituted Enals by Using a Diazepane Carboxylate Catalyst

European journal of organic chemistry, 2017-05, Vol.2017 (18), p.2637-2640

2017

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Rapid End-Game Process Development and First GMP Production of MK-7845: An Experimental Antiviral Treatment for COVID-19

Organic process research & development, 2024-06, Vol.28 (6), p.2157-2167

2024

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Direct Intramolecular Catalytic Enantioselective Alkylation of Oxazolidinone Bromoalkanoate Imides

Synlett, 2014-10, Vol.25 (19), p.2802-2805

2014

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Organocatalytic Michael Addition of Indoles to [alpha]-Substituted Enals by Using a Diazepane Carboxylate Catalyst

European journal of organic chemistry, 2017-05, Vol.2017 (18), p.2637

2017

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A Concise Enantioselective Total Synthesis of (−)‐Virosaine A

Angewandte Chemie, 2017-08, Vol.129 (36), p.10970-10974

2017

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A Concise Enantioselective Total Synthesis of (-)-VirosaineA

Angewandte Chemie, 2017-08, Vol.129 (36), p.10970

2017

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I. A Total Synthesis of (−)-Virosaine A. II. A Direct Approach for the Synthesis of 1,3-Disubstituted Bicyclo[1.1.1]pentan-1-amines

Hughes, Jonathan M. E

2017

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An intramolecular coupling approach to alkyl bioisosteres for the synthesis of multisubstituted bicycloalkyl boronates

Aminoalkylation of [1.1.1]Propellane Enables Direct Access to High-Value 3‑Alkylbicyclo[1.1.1]pentan-1-amines

Enantioenriched BCP Benzylamine Synthesis via Metal Hydride Hydrogen Atom Transfer/Sulfinimine Addition to [1.1.1]Propellane

Desulfonylative Arylation of Redox-Active Alkyl Sulfones with Aryl Bromides

Continuous Flow-Enabled Synthesis of Bench-Stable Bicyclo[1.1.1]pentane Trifluoroborate Salts and Their Utilization in Metallaphotoredox Cross-Couplings

A Concise Enantioselective Total Synthesis of (−)‐Virosaine A

Strain-release 2-azaallyl anion addition/borylation of [1.1.1]propellane: synthesis and functionalization of benzylamine bicyclo[1.1.1]pentyl boronates

Alkyl sulfinates as cross-coupling partners for programmable and stereospecific installation of C(sp3) bioisosteres

Programmable late-stage functionalization of bridge-substituted bicyclo[1.1.1]pentane bis-boronates

The Discovery of Two Novel Classes of 5,5-Bicyclic Nucleoside-Derived PRMT5 Inhibitors for the Treatment of Cancer

Synthesis of α‑Aryl Secondary Amides via Nickel-Catalyzed Reductive Coupling of Redox-Active Esters

Practical and Modular Construction of C(sp 3 )-Rich Alkyl Boron Compounds

Uncanonical Semireduction of Quinolines and Isoquinolines via Regioselective HAT-Promoted Hydrosilylation

Asymmetric Synthesis of Tertiary and Secondary Cyclopropyl Boronates via Cyclopropanation of Enantioenriched Alkenyl Boronic Esters

Nickel-Catalyzed Reductive Arylation of Redox Active Esters for the Synthesis of α-Aryl Nitriles: Investigation of a Chlorosilane Additive

Cerastecin Inhibition of the Lipooligosaccharide Transporter MsbA to Combat Acinetobacter baumannii : From Screening Impurity to In Vivo Efficacy

A Concise Enantioselective Total Synthesis of (-)-VirosaineA

Intramolecular Coupling for General Synthesis of Backbone Substituted Bicyclo[1.1.1]pentyl Boronates

Organocatalytic Michael Addition of Indoles to α‐Substituted Enals by Using a Diazepane Carboxylate Catalyst

Rapid End-Game Process Development and First GMP Production of MK-7845: An Experimental Antiviral Treatment for COVID-19

Direct Intramolecular Catalytic Enantioselective Alkylation of Oxazolidinone Bromoalkanoate Imides

Organocatalytic Michael Addition of Indoles to [alpha]-Substituted Enals by Using a Diazepane Carboxylate Catalyst

A Concise Enantioselective Total Synthesis of (−)‐Virosaine A

A Concise Enantioselective Total Synthesis of (-)-VirosaineA

I. A Total Synthesis of (−)-Virosaine A. II. A Direct Approach for the Synthesis of 1,3-Disubstituted Bicyclo[1.1.1]pentan-1-amines

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