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CCR2 modulates inflammatory and metabolic effects of high-fat feeding

The Journal of clinical investigation, 2006-01, Vol.116 (1), p.115-124

2006

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Preclinical characterization of INCB053914, a novel pan-PIM kinase inhibitor, alone and in combination with anticancer agents, in models of hematologic malignancies

PloS one, 2018-06, Vol.13 (6), p.e0199108-e0199108

2018

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Abstract IA23: Enhancing anti-tumor immunity through selective inhibition of IDO1

Clinical cancer research, 2017-01, Vol.23 (1_Supplement), p.IA23-IA23

Huber, Reid

2017

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Abstract 3819: INCAGN02385 is an antagonist antibody targeting the co-inhibitory receptor LAG-3 for the treatment of human malignancies

Cancer research (Chicago, Ill.), 2018-07, Vol.78 (13_Supplement), p.3819-3819

2018

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Discovery and Pharmacological Characterization of a Novel Rodent-Active CCR2 Antagonist, INCB3344

The Journal of immunology (1950), 2005-10, Vol.175 (8), p.5370-5378

2005

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Generation of multiple farnesoid-X-receptor isoforms through the use of alternative promoters

Gene, 2002-05, Vol.290 (1), p.35-43

2002

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Identification of ADAM10 as a major source of HER2 ectodomain sheddase activity in HER2 overexpressing breast cancer cells

Cancer biology & therapy, 2006-06, Vol.5 (6), p.657-664

2006

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The effect of long-term ruxolitinib treatment on JAK2p.V617F allele burden in patients with myelofibrosis

Blood, 2015-09, Vol.126 (13), p.1551-1554

2015

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Mutations in GPC3 , a glypican gene, cause the Simpson-Golabi-Behmel overgrowth syndrome

Nature genetics, 1996-03, Vol.12 (3), p.241-247

1996

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Dexamethasone and Tumor Necrosis Factor-α Act Together to Induce the Cellular Inhibitor of Apoptosis-2 Gene and Prevent Apoptosis in a Variety of Cell Types

Endocrinology (Philadelphia), 2002-10, Vol.143 (10), p.3866-3874

2002

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Absence of Post-translational Aspartyl β-Hydroxylation of Epidermal Growth Factor Domains in Mice Leads to Developmental Defects and an Increased Incidence of Intestinal Neoplasia

The Journal of biological chemistry, 2002-04, Vol.277 (15), p.12970-12977

2002

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Discovery of Pemigatinib: A Potent and Selective Fibroblast Growth Factor Receptor (FGFR) Inhibitor

Journal of medicinal chemistry, 2021-08, Vol.64 (15), p.10666-10679

2021

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11-β-Hydroxysteroid Dehydrogenase Type 1 Inhibitor INCB13739 Improves Hyperglycemia in Patients With Type 2 Diabetes Inadequately Controlled by Metformin Monotherapy

Diabetes care, 2010-07, Vol.33 (7), p.1516-1522

2010

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Itacitinib, a JAK1 Selective Inhibitor Preserves Graft-Versus-Leukemia (GVL), Enhances Survival and Is Highly Efficacious in a MHC-Mismatched Mouse Model of Acute GvHD

Blood, 2018-11, Vol.132 (Supplement 1), p.4522-4522

2018

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Ruxolitinib, a JAK1/JAK2 Selective Inhibitor Is Highly Efficacious in Corticosteroid Untreated and Refractory MHC-Mismatched Mouse Model of Acute GvHD

Blood, 2018-11, Vol.132 (Supplement 1), p.4523-4523

2018

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A human CD137×PD-L1 bispecific antibody promotes anti-tumor immunity via context-dependent T cell costimulation and checkpoint blockade

Nature communications, 2021-07, Vol.12 (1), p.4445-19, Article 4445

2021

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Parsaclisib Is a Next-Generation Phosphoinositide 3-Kinase δ Inhibitor with Reduced Hepatotoxicity and Potent Antitumor and Immunomodulatory Activities in Models of B-Cell Malignancy

The Journal of pharmacology and experimental therapeutics, 2020-07, Vol.374 (1), p.211-222

2020

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PLAC1, a trophoblast-specific gene, is expressed throughout pregnancy in the human placenta and modulated by keratinocyte growth factor

Molecular reproduction and development, 2002-12, Vol.63 (4), p.430-436

2002

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Abstract 2938: In vivo assessment of the combination of the JAK1 selective inhibitor itacitinib with first- and second-generation EGFR inhibitors in models of non-small cell lung cancer

Cancer research (Chicago, Ill.), 2018-07, Vol.78 (13_Supplement), p.2938-2938

2018

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Current themes in microarray experimental design and analysis

Drug discovery today, 2002-03, Vol.7 (5), p.290-292

2002

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Discovery of 1′-(1-phenylcyclopropane-carbonyl)-3H-spiro[isobenzofuran-1,3′-pyrrolidin]-3-one as a novel steroid mimetic scaffold for the potent and tissue-specific inhibition of 11β-HSD1 using a scaffold-hopping approach

Bioorganic & medicinal chemistry letters, 2022-08, Vol.69, p.128782-128782, Article 128782

2022

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Abstract 1876: INCB052793, a JAK1 selective inhibitor, is highly efficacious in PDX and xenograft models of acute myeloid leukemia (AML) expressing elevated endogenous pSTAT3/pSTAT5

Cancer research (Chicago, Ill.), 2018-07, Vol.78 (13_Supplement), p.1876-1876

2018

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INCB054828 (pemigatinib), a potent and selective inhibitor of fibroblast growth factor receptors 1, 2, and 3, displays activity against genetically defined tumor models

CCR2 modulates inflammatory and metabolic effects of high-fat feeding

Preclinical characterization of INCB053914, a novel pan-PIM kinase inhibitor, alone and in combination with anticancer agents, in models of hematologic malignancies

Abstract IA23: Enhancing anti-tumor immunity through selective inhibition of IDO1

Abstract 3819: INCAGN02385 is an antagonist antibody targeting the co-inhibitory receptor LAG-3 for the treatment of human malignancies

Discovery and Pharmacological Characterization of a Novel Rodent-Active CCR2 Antagonist, INCB3344

Generation of multiple farnesoid-X-receptor isoforms through the use of alternative promoters

Identification of ADAM10 as a major source of HER2 ectodomain sheddase activity in HER2 overexpressing breast cancer cells

The effect of long-term ruxolitinib treatment on JAK2p.V617F allele burden in patients with myelofibrosis

Mutations in GPC3 , a glypican gene, cause the Simpson-Golabi-Behmel overgrowth syndrome

Dexamethasone and Tumor Necrosis Factor-α Act Together to Induce the Cellular Inhibitor of Apoptosis-2 Gene and Prevent Apoptosis in a Variety of Cell Types

Absence of Post-translational Aspartyl β-Hydroxylation of Epidermal Growth Factor Domains in Mice Leads to Developmental Defects and an Increased Incidence of Intestinal Neoplasia

Discovery of Pemigatinib: A Potent and Selective Fibroblast Growth Factor Receptor (FGFR) Inhibitor

Characterization of INCB086550: A Potent and Novel Small-Molecule PD-L1 Inhibitor

11-β-Hydroxysteroid Dehydrogenase Type 1 Inhibitor INCB13739 Improves Hyperglycemia in Patients With Type 2 Diabetes Inadequately Controlled by Metformin Monotherapy

Itacitinib, a JAK1 Selective Inhibitor Preserves Graft-Versus-Leukemia (GVL), Enhances Survival and Is Highly Efficacious in a MHC-Mismatched Mouse Model of Acute GvHD

Ruxolitinib, a JAK1/JAK2 Selective Inhibitor Is Highly Efficacious in Corticosteroid Untreated and Refractory MHC-Mismatched Mouse Model of Acute GvHD

A human CD137×PD-L1 bispecific antibody promotes anti-tumor immunity via context-dependent T cell costimulation and checkpoint blockade

Parsaclisib Is a Next-Generation Phosphoinositide 3-Kinase δ Inhibitor with Reduced Hepatotoxicity and Potent Antitumor and Immunomodulatory Activities in Models of B-Cell Malignancy

PLAC1, a trophoblast-specific gene, is expressed throughout pregnancy in the human placenta and modulated by keratinocyte growth factor

Abstract 2938: In vivo assessment of the combination of the JAK1 selective inhibitor itacitinib with first- and second-generation EGFR inhibitors in models of non-small cell lung cancer

The Novel Bromodomain and Extraterminal Domain Inhibitor INCB054329 Induces Vulnerabilities in Myeloma Cells That Inform Rational Combination Strategies

Current themes in microarray experimental design and analysis

Discovery of 1′-(1-phenylcyclopropane-carbonyl)-3H-spiro[isobenzofuran-1,3′-pyrrolidin]-3-one as a novel steroid mimetic scaffold for the potent and tissue-specific inhibition of 11β-HSD1 using a scaffold-hopping approach

Abstract 1876: INCB052793, a JAK1 selective inhibitor, is highly efficacious in PDX and xenograft models of acute myeloid leukemia (AML) expressing elevated endogenous pSTAT3/pSTAT5

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