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Berberine promotes the recruitment and activation of brown adipose tissue in mice and humans

Cell death & disease, 2019-06, Vol.10 (6), p.468-18, Article 468

2019

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Targeting C/EBPα overcomes primary resistance and improves the efficacy of FLT3 inhibitors in acute myeloid leukaemia

Nature communications, 2023-04, Vol.14 (1), p.1882-1882, Article 1882

2023

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Disruption of the unfolded protein response (UPR) by lead compound selectively suppresses cancer cell growth

Cancer letters, 2015-05, Vol.360 (2), p.257-268

2015

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Identification of 2‑Aminopyrimidine Derivatives as FLT3 Kinase Inhibitors with High Selectivity over c‑KIT

Journal of medicinal chemistry, 2022-02, Vol.65 (4), p.3229-3248

2022

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Discovery of thalidomide-based PROTAC small molecules as the highly efficient SHP2 degraders

European journal of medicinal chemistry, 2021-06, Vol.218, p.113341-113341, Article 113341

2021

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Discovery of 2‑Aminopyrimidine Derivatives as Potent Dual FLT3/CHK1 Inhibitors with Significantly Reduced hERG Inhibitory Activities

Journal of medicinal chemistry, 2023-09, Vol.66 (17), p.11792-11814

2023

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Discovery of JN122, a Spiroindoline-Containing Molecule that Inhibits MDM2/p53 Protein–Protein Interaction and Exerts Robust In Vivo Antitumor Efficacy

Journal of medicinal chemistry, 2023-12, Vol.66 (24), p.16991-17025

2023

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Design, synthesis, and biological evaluation of Wee1 kinase degraders

European journal of medicinal chemistry, 2022-12, Vol.243, p.114786-114786, Article 114786

2022

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Discovery of pyrazole-thiophene derivatives as highly Potent, orally active Akt inhibitors

European journal of medicinal chemistry, 2019-10, Vol.180, p.72-85

2019

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Discovery and Development of a Potent, Selective, and Orally Bioavailable CHK1 Inhibitor Candidate: 5‑((4-((3-Amino-3-methylbutyl)amino)-5-(trifluoromethyl)pyrimidin-2-yl)amino)picolinonitrile

Journal of medicinal chemistry, 2021-10, Vol.64 (20), p.15069-15090

2021

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Mechanical Stress Affects Circadian Rhythm in Skeletal Muscle (C2C12 Myoblasts) by Reducing Per/Cry Gene Expression and Increasing Bmal1 Gene Expression

Medical science monitor, 2021-01, Vol.27, p.e928359-e928359

2021

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Rational Design and Development of Novel CDK9 Inhibitors for the Treatment of Acute Myeloid Leukemia

Journal of medicinal chemistry, 2021-10, Vol.64 (19), p.14647-14663

2021

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Dual inhibition of CHK1/FLT3 enhances cytotoxicity and overcomes adaptive and acquired resistance in FLT3-ITD acute myeloid leukemia

Leukemia, 2023-03, Vol.37 (3), p.539-549

2023

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Discovery of (R)-5-((5-(1-methyl-1H-pyrazol-4-yl)-4-(methylamino)pyrimidin-2-yl)amino)-3-(piperidin-3-yloxy)picolinonitrile, a novel CHK1 inhibitor for hematologic malignancies

European journal of medicinal chemistry, 2019-07, Vol.173, p.44-62

2019

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Development of Macrocyclic Peptides Containing Epoxyketone with Oral Availability as Proteasome Inhibitors

Journal of medicinal chemistry, 2018-10, Vol.61 (20), p.9177-9204

2018

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Integrated analysis of single-cell RNA-seq and bulk RNA-seq reveals distinct cancer-associated fibroblasts in head and neck squamous cell carcinoma

Annals of translational medicine, 2021-06, Vol.9 (12), p.1017-1017

2021

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Structure-based design, synthesis and bioactivity evaluation of macrocyclic inhibitors of mutant isocitrate dehydrogenase 2 (IDH2) displaying activity in acute myeloid leukemia cells

European journal of medicinal chemistry, 2020-10, Vol.203, p.112491-112491, Article 112491

2020

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Exploration of novel piperazine or piperidine constructed non-covalent peptidyl derivatives as proteasome inhibitors

European journal of medicinal chemistry, 2017-01, Vol.126, p.1056-1070

2017

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Ultra-sensitive graphene strain sensor for sound signal acquisition and recognition

Nano research, 2015-05, Vol.8 (5), p.1627-1636

2015

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Effectiveness of convalescent plasma therapy in severe COVID-19 patients

Proceedings of the National Academy of Sciences - PNAS, 2020-04, Vol.117 (17), p.9490-9496

2020

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Social support, source credibility, social influence, and solar photovoltaic panels purchase intention

Environmental science and pollution research international, 2021-11, Vol.28 (41), p.57842-57859

2021

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A NaH-promoted N-detosylation reaction of diverse p-toluenesulfonamides

Tetrahedron letters, 2020-10, Vol.61 (43), p.152442, Article 152442

2020

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Study of growth, metabolism, and morphology of Akkermansia muciniphila with an in vitro advanced bionic intestinal reactor

BMC microbiology, 2021-02, Vol.21 (1), p.61-61, Article 61

2021

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Research on the Effects of Information Description on Crowdfunding Success within a Sustainable Economy—The Perspective of Information Communication

Sustainability, 2020-01, Vol.12 (2), p.650

2020

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Elevated Exhaustion Levels of NK and CD8 + T Cells as Indicators for Progression and Prognosis of COVID-19 Disease

Frontiers in immunology, 2020-10, Vol.11, p.580237-580237

2020

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Berberine promotes the recruitment and activation of brown adipose tissue in mice and humans

Targeting C/EBPα overcomes primary resistance and improves the efficacy of FLT3 inhibitors in acute myeloid leukaemia

Disruption of the unfolded protein response (UPR) by lead compound selectively suppresses cancer cell growth

Identification of 2‑Aminopyrimidine Derivatives as FLT3 Kinase Inhibitors with High Selectivity over c‑KIT

Discovery of thalidomide-based PROTAC small molecules as the highly efficient SHP2 degraders

Discovery of 2‑Aminopyrimidine Derivatives as Potent Dual FLT3/CHK1 Inhibitors with Significantly Reduced hERG Inhibitory Activities

Discovery of JN122, a Spiroindoline-Containing Molecule that Inhibits MDM2/p53 Protein–Protein Interaction and Exerts Robust In Vivo Antitumor Efficacy

Design, synthesis, and biological evaluation of Wee1 kinase degraders

Discovery of pyrazole-thiophene derivatives as highly Potent, orally active Akt inhibitors

Discovery and Development of a Potent, Selective, and Orally Bioavailable CHK1 Inhibitor Candidate: 5‑((4-((3-Amino-3-methylbutyl)amino)-5-(trifluoromethyl)pyrimidin-2-yl)amino)picolinonitrile

Mechanical Stress Affects Circadian Rhythm in Skeletal Muscle (C2C12 Myoblasts) by Reducing Per/Cry Gene Expression and Increasing Bmal1 Gene Expression

Rational Design and Development of Novel CDK9 Inhibitors for the Treatment of Acute Myeloid Leukemia

Dual inhibition of CHK1/FLT3 enhances cytotoxicity and overcomes adaptive and acquired resistance in FLT3-ITD acute myeloid leukemia

Discovery of (R)-5-((5-(1-methyl-1H-pyrazol-4-yl)-4-(methylamino)pyrimidin-2-yl)amino)-3-(piperidin-3-yloxy)picolinonitrile, a novel CHK1 inhibitor for hematologic malignancies

Development of Macrocyclic Peptides Containing Epoxyketone with Oral Availability as Proteasome Inhibitors

Integrated analysis of single-cell RNA-seq and bulk RNA-seq reveals distinct cancer-associated fibroblasts in head and neck squamous cell carcinoma

Structure-based design, synthesis and bioactivity evaluation of macrocyclic inhibitors of mutant isocitrate dehydrogenase 2 (IDH2) displaying activity in acute myeloid leukemia cells

Exploration of novel piperazine or piperidine constructed non-covalent peptidyl derivatives as proteasome inhibitors

Ultra-sensitive graphene strain sensor for sound signal acquisition and recognition

Effectiveness of convalescent plasma therapy in severe COVID-19 patients

Social support, source credibility, social influence, and solar photovoltaic panels purchase intention

A NaH-promoted N-detosylation reaction of diverse p-toluenesulfonamides

Study of growth, metabolism, and morphology of Akkermansia muciniphila with an in vitro advanced bionic intestinal reactor

Research on the Effects of Information Description on Crowdfunding Success within a Sustainable Economy—The Perspective of Information Communication

Elevated Exhaustion Levels of NK and CD8 + T Cells as Indicators for Progression and Prognosis of COVID-19 Disease

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