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Oral Tecovirimat for the Treatment of Smallpox

The New England journal of medicine, 2018-07, Vol.379 (1), p.44-53

2018

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Comparison of the safety and pharmacokinetics of ST-246® after i.v. infusion or oral administration in mice, rabbits and monkeys

PloS one, 2011-08, Vol.6 (8), p.e23237

2011

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Overview of the regulatory approval of tecovirimat intravenous formulation for treatment of smallpox: potential impact on smallpox outbreak response capabilities, and future tecovirimat development potential

Expert review of anti-infective therapy, 2023-03, Vol.21 (3), p.235-242

2023

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ST-246 is a key antiviral to inhibit the viral F13L phospholipase, one of the essential proteins for orthopoxvirus wrapping

Journal of antimicrobial chemotherapy, 2015-05, Vol.70 (5), p.1367-1380

2015

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A Novel Inhibitor of Dengue Virus Replication That Targets the Capsid Protein

Antimicrobial Agents and Chemotherapy, 2013-01, Vol.57 (1), p.15-25

2013

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Smallpox lesion characterization in placebo-treated and tecovirimat-treated macaques using traditional and novel methods

PLoS pathogens, 2024-02, Vol.20 (2), p.e1012007-e1012007

2024

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Efficacy of Tecovirimat (ST-246) in Nonhuman Primates Infected with Variola Virus (Smallpox)

Antimicrobial Agents and Chemotherapy, 2013-12, Vol.57 (12), p.6246-6253

2013

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Novel Benzoxazole Inhibitor of Dengue Virus Replication That Targets the NS3 Helicase

Antimicrobial Agents and Chemotherapy, 2013-04, Vol.57 (4), p.1902-1912

2013

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Identification of a Broad-Spectrum Arenavirus Entry Inhibitor

Journal of Virology, 2008-11, Vol.82 (21), p.10768-10775

2008

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Progressive Vaccinia: Case Description and Laboratory-Guided Therapy With Vaccinia Immune Globulin, ST-246, and CMX001

The Journal of infectious diseases, 2012-11, Vol.206 (9), p.1372-1385

2012

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Effective Antiviral Treatment of Systemic Orthopoxvirus Disease: ST-246 Treatment of Prairie Dogs Infected with Monkeypox Virus

Journal of Virology, 2011-09, Vol.85 (17), p.9176-9187

2011

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Effects of tillage and poultry manure application rates on Salmonella and fecal indicator bacteria concentrations in tiles draining Des Moines Lobe soils

Journal of environmental management, 2016-04, Vol.171, p.60-69

2016

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Development of ST-246® for Treatment of Poxvirus Infections

Viruses, 2010-11, Vol.2 (11), p.2409-2435

2010

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Synergistic Efficacy of the Combination of ST-246 with CMX001 against Orthopoxviruses

Antimicrobial Agents and Chemotherapy, 2007-11, Vol.51 (11), p.4118-4124

2007

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ST-246 Antiviral Efficacy in a Nonhuman Primate Monkeypox Model: Determination of the Minimal Effective Dose and Human Dose Justification

Antimicrobial Agents and Chemotherapy, 2009-05, Vol.53 (5), p.1817-1822

2009

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Efficacy of Delayed Treatment with ST-246 Given Orally against Systemic Orthopoxvirus Infections in Mice

Antimicrobial Agents and Chemotherapy, 2007-02, Vol.51 (2), p.689-695

2007

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An overview of tecovirimat for smallpox treatment and expanded anti-orthopoxvirus applications

Expert review of anti-infective therapy, 2021-03, Vol.19 (3), p.331-344

2021

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Safety and Pharmacokinetics of the Anti-Orthopoxvirus Compound ST-246 following a Single Daily Oral Dose for 14 Days in Human Volunteers

Antimicrobial Agents and Chemotherapy, 2012-09, Vol.56 (9), p.4900-4905

2012

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Evaluation of Lassa antiviral compound ST-193 in a guinea pig model

Antiviral research, 2011-04, Vol.90 (1), p.70-79

2011

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In Vitro Efficacy of ST246 against Smallpox and Monkeypox

Antimicrobial Agents and Chemotherapy, 2009-03, Vol.53 (3), p.1007-1012

2009

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ST-246 Inhibits In Vivo Poxvirus Dissemination, Virus Shedding, and Systemic Disease Manifestation

Antimicrobial Agents and Chemotherapy, 2009-12, Vol.53 (12), p.4999-5009

2009

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Occurrence of neonicotinoids and sulfoxaflor in major aquifer groups in Iowa

Chemosphere (Oxford), 2021-10, Vol.281, p.130856, Article 130856

2021

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Efficacy of ST-246 versus lethal poxvirus challenge in immunodeficient mice

Proceedings of the National Academy of Sciences - PNAS, 2010-01, Vol.107 (2), p.838-843

2010

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The Vaccinia Virus F13L YPPL Motif Is Required for Efficient Release of Extracellular Enveloped Virus

Journal of Virology, 2007-07, Vol.81 (13), p.7310-7315

2007

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Single-Dose Safety and Pharmacokinetics of ST-246, a Novel Orthopoxvirus Egress Inhibitor

Antimicrobial Agents and Chemotherapy, 2008-05, Vol.52 (5), p.1721-1727

2008

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Oral Tecovirimat for the Treatment of Smallpox

Comparison of the safety and pharmacokinetics of ST-246® after i.v. infusion or oral administration in mice, rabbits and monkeys

Overview of the regulatory approval of tecovirimat intravenous formulation for treatment of smallpox: potential impact on smallpox outbreak response capabilities, and future tecovirimat development potential

ST-246 is a key antiviral to inhibit the viral F13L phospholipase, one of the essential proteins for orthopoxvirus wrapping

A Novel Inhibitor of Dengue Virus Replication That Targets the Capsid Protein

Smallpox lesion characterization in placebo-treated and tecovirimat-treated macaques using traditional and novel methods

Efficacy of Tecovirimat (ST-246) in Nonhuman Primates Infected with Variola Virus (Smallpox)

Novel Benzoxazole Inhibitor of Dengue Virus Replication That Targets the NS3 Helicase

Identification of a Broad-Spectrum Arenavirus Entry Inhibitor

Progressive Vaccinia: Case Description and Laboratory-Guided Therapy With Vaccinia Immune Globulin, ST-246, and CMX001

Effective Antiviral Treatment of Systemic Orthopoxvirus Disease: ST-246 Treatment of Prairie Dogs Infected with Monkeypox Virus

Effects of tillage and poultry manure application rates on Salmonella and fecal indicator bacteria concentrations in tiles draining Des Moines Lobe soils

Development of ST-246® for Treatment of Poxvirus Infections

Synergistic Efficacy of the Combination of ST-246 with CMX001 against Orthopoxviruses

ST-246 Antiviral Efficacy in a Nonhuman Primate Monkeypox Model: Determination of the Minimal Effective Dose and Human Dose Justification

Efficacy of Delayed Treatment with ST-246 Given Orally against Systemic Orthopoxvirus Infections in Mice

An overview of tecovirimat for smallpox treatment and expanded anti-orthopoxvirus applications

Safety and Pharmacokinetics of the Anti-Orthopoxvirus Compound ST-246 following a Single Daily Oral Dose for 14 Days in Human Volunteers

Evaluation of Lassa antiviral compound ST-193 in a guinea pig model

In Vitro Efficacy of ST246 against Smallpox and Monkeypox

ST-246 Inhibits In Vivo Poxvirus Dissemination, Virus Shedding, and Systemic Disease Manifestation

Occurrence of neonicotinoids and sulfoxaflor in major aquifer groups in Iowa

Efficacy of ST-246 versus lethal poxvirus challenge in immunodeficient mice

The Vaccinia Virus F13L YPPL Motif Is Required for Efficient Release of Extracellular Enveloped Virus

Single-Dose Safety and Pharmacokinetics of ST-246, a Novel Orthopoxvirus Egress Inhibitor

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