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A high-fat diet promotes depression-like behavior in mice by suppressing hypothalamic PKA signaling

Translational psychiatry, 2019-05, Vol.9 (1), p.141-141, Article 141

2019

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Sleep deprivation causes memory deficits by negatively impacting neuronal connectivity in hippocampal area CA1

eLife, 2016-08, Vol.5

2016

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Oxygen-Dependent Cleavage of the p75 Neurotrophin Receptor Triggers Stabilization of HIF-1α

Molecular cell, 2011-11, Vol.44 (3), p.476-490

2011

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Disrupted-in-Schizophrenia 1 (DISC1) regulates spines of the glutamate synapse via Rac1

Nature neuroscience, 2010-03, Vol.13 (3), p.327-332

2010

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Underpinning compartmentalised cAMP signalling through targeted cAMP breakdown

Trends in biochemical sciences (Amsterdam. Regular ed.), 2010-02, Vol.35 (2), p.91-100

Houslay, Miles D.

2010

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PKA phosphorylation of p62/SQSTM1 regulates PB1 domain interaction partner binding

Biochimica et biophysica acta. Molecular cell research, 2014-11, Vol.1843 (11), p.2765-2774

2014

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Regulation of sensorimotor gating via Disc1/Huntingtin-mediated Bdnf transport in the cortico-striatal circuit

Molecular psychiatry, 2022-03, Vol.27 (3), p.1805-1815

2022

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Integrating cardiac PIP3 and cAMP signaling through a PKA anchoring function of p110γ

Molecular cell, 2011-04, Vol.42 (1), p.84-95

2011

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The role of ventral striatal cAMP signaling in stress-induced behaviors

Nature neuroscience, 2015-08, Vol.18 (8), p.1094-1100

2015

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Protein Kinase A Type I and Type II Define Distinct Intracellular Signaling Compartments

Circulation research, 2008-10, Vol.103 (8), p.836-844

2008

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The Cardiac IKs Potassium Channel Macromolecular Complex Includes the Phosphodiesterase PDE4D3

The Journal of biological chemistry, 2009-04, Vol.284 (14), p.9140-9146

2009

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Phosphorylation of cAMP-specific PDE4A5 (phosphodiesterase-4A5) by MK2 (MAPKAPK2) attenuates its activation through protein kinase A phosphorylation

Biochemical journal, 2011-05, Vol.435 (3), p.755-769

2011

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Compartmentalized PDE4A5 Signaling Impairs Hippocampal Synaptic Plasticity and Long-Term Memory

The Journal of neuroscience, 2016-08, Vol.36 (34), p.8936-8946

2016

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Aggregation of scaffolding protein DISC1 dysregulates phosphodiesterase 4 in Huntington's disease

The Journal of clinical investigation, 2017-04, Vol.127 (4), p.1438-1450

2017

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Structures of the four subfamilies of phosphodiesterase-4 provide insight into the selectivity of their inhibitors

Biochemical journal, 2007-12, Vol.408 (2), p.193-201

2007

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Fluorescence Resonance Energy Transfer–Based Analysis of cAMP Dynamics in Live Neonatal Rat Cardiac Myocytes Reveals Distinct Functions of Compartmentalized Phosphodiesterases

Circulation research, 2004-07, Vol.95 (1), p.67-75

2004

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Activation of Phosphodiesterase 3A: New Hope for Cardioprotection

Circulation (New York, N.Y.), 2022-12, Vol.146 (23), p.1779-1782

2022

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EPAC and PKA allow cAMP dual control over DNA-PK nuclear translocation

Proceedings of the National Academy of Sciences - PNAS, 2008-09, Vol.105 (35), p.12791-12796

2008

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The RACK1 scaffold protein: a dynamic cog in cell response mechanisms

Molecular pharmacology, 2002-12, Vol.62 (6), p.1261-1273

2002

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p75 Neurotrophin Receptor Regulates Energy Balance in Obesity

Cell reports (Cambridge), 2016-01, Vol.14 (2), p.255-268

2016

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Isoform-Selective Susceptibility of DISC1/Phosphodiesterase-4 Complexes to Dissociation by Elevated Intracellular cAMP Levels

The Journal of neuroscience, 2007-08, Vol.27 (35), p.9513-9524

2007

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β-Arrestin-mediated PDE4 cAMP phosphodiesterase recruitment regulates β-adrenoceptor switching from Gs to Gi

Proceedings of the National Academy of Sciences - PNAS, 2003-02, Vol.100 (3), p.940-945

2003

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Cyclic AMP Phosphodiesterase 4D (PDE4D) Tethers EPAC1 in a Vascular Endothelial Cadherin (VE-Cad)-based Signaling Complex and Controls cAMP-mediated Vascular Permeability

The Journal of biological chemistry, 2010-10, Vol.285 (44), p.33614-33622

2010

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Phosphorylation of RACK1 on Tyrosine 52 by c-Abl Is Required for Insulin-like Growth Factor I-mediated Regulation of Focal Adhesion Kinase

The Journal of biological chemistry, 2009-07, Vol.284 (30), p.20263-20274

2009

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Scanning peptide array analyses identify overlapping binding sites for the signalling scaffold proteins, beta-arrestin and RACK1, in cAMP-specific phosphodiesterase PDE4D5

Biochemical journal, 2006-08, Vol.398 (1), p.23-36

2006

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A high-fat diet promotes depression-like behavior in mice by suppressing hypothalamic PKA signaling

Sleep deprivation causes memory deficits by negatively impacting neuronal connectivity in hippocampal area CA1

Oxygen-Dependent Cleavage of the p75 Neurotrophin Receptor Triggers Stabilization of HIF-1α

Disrupted-in-Schizophrenia 1 (DISC1) regulates spines of the glutamate synapse via Rac1

Underpinning compartmentalised cAMP signalling through targeted cAMP breakdown

PKA phosphorylation of p62/SQSTM1 regulates PB1 domain interaction partner binding

Regulation of sensorimotor gating via Disc1/Huntingtin-mediated Bdnf transport in the cortico-striatal circuit

Integrating cardiac PIP3 and cAMP signaling through a PKA anchoring function of p110γ

The role of ventral striatal cAMP signaling in stress-induced behaviors

Protein Kinase A Type I and Type II Define Distinct Intracellular Signaling Compartments

The Cardiac IKs Potassium Channel Macromolecular Complex Includes the Phosphodiesterase PDE4D3

Phosphorylation of cAMP-specific PDE4A5 (phosphodiesterase-4A5) by MK2 (MAPKAPK2) attenuates its activation through protein kinase A phosphorylation

Compartmentalized PDE4A5 Signaling Impairs Hippocampal Synaptic Plasticity and Long-Term Memory

Aggregation of scaffolding protein DISC1 dysregulates phosphodiesterase 4 in Huntington's disease

Structures of the four subfamilies of phosphodiesterase-4 provide insight into the selectivity of their inhibitors

Fluorescence Resonance Energy Transfer–Based Analysis of cAMP Dynamics in Live Neonatal Rat Cardiac Myocytes Reveals Distinct Functions of Compartmentalized Phosphodiesterases

Activation of Phosphodiesterase 3A: New Hope for Cardioprotection

EPAC and PKA allow cAMP dual control over DNA-PK nuclear translocation

The RACK1 scaffold protein: a dynamic cog in cell response mechanisms

p75 Neurotrophin Receptor Regulates Energy Balance in Obesity

Isoform-Selective Susceptibility of DISC1/Phosphodiesterase-4 Complexes to Dissociation by Elevated Intracellular cAMP Levels

β-Arrestin-mediated PDE4 cAMP phosphodiesterase recruitment regulates β-adrenoceptor switching from Gs to Gi

Cyclic AMP Phosphodiesterase 4D (PDE4D) Tethers EPAC1 in a Vascular Endothelial Cadherin (VE-Cad)-based Signaling Complex and Controls cAMP-mediated Vascular Permeability

Phosphorylation of RACK1 on Tyrosine 52 by c-Abl Is Required for Insulin-like Growth Factor I-mediated Regulation of Focal Adhesion Kinase

Scanning peptide array analyses identify overlapping binding sites for the signalling scaffold proteins, beta-arrestin and RACK1, in cAMP-specific phosphodiesterase PDE4D5

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