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Apremilast, a cAMP phosphodiesterase‐4 inhibitor, demonstrates anti‐inflammatory activity in vitro and in a model of psoriasis

British journal of pharmacology, 2010-02, Vol.159 (4), p.842-855

2010

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The cAMP phosphodiesterase-4D7 (PDE4D7) is downregulated in androgen-independent prostate cancer cells and mediates proliferation by compartmentalising cAMP at the plasma membrane of VCaP prostate cancer cells

British journal of cancer, 2014-03, Vol.110 (5), p.1278-1287

2014

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β-Arrestin 1 Inhibits the GTPase-Activating Protein Function of ARHGAP21, Promoting Activation of RhoA following Angiotensin II Type 1A Receptor Stimulation

Molecular and Cellular Biology, 2011-03, Vol.31 (5), p.1066-1075

2011

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The role of the PDE4D cAMP phosphodiesterase in the regulation of glucagon‐like peptide‐1 release

British journal of pharmacology, 2009-06, Vol.157 (4), p.633-644

2009

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Phosphorylation of PDE4A5 by MAPKAPK2 attenuates fibrin degradation via p75 signalling

Journal of biochemistry (Tokyo), 2019-07, Vol.166 (1), p.97-106

2019

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Disruption of the cyclic AMP phosphodiesterase-4 (PDE4)–HSP20 complex attenuates the β-agonist induced hypertrophic response in cardiac myocytes

Journal of molecular and cellular cardiology, 2011-05, Vol.50 (5), p.872-883

2011

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FBXW7 regulates DISC1 stability via the ubiquitin-proteosome system

Molecular psychiatry, 2018-05, Vol.23 (5), p.1278-1286

2018

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The psychiatric disease risk factors DISC1 and TNIK interact to regulate synapse composition and function

Molecular psychiatry, 2011-10, Vol.16 (10), p.1006-1023

2011

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Epac and the high affinity rolipram binding conformer of PDE4 modulate neurite outgrowth and myelination using an in vitro spinal cord injury model

British journal of pharmacology, 2014-05, Vol.171 (9), p.2385-2398

2014

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The role of ERK2 docking and phosphorylation of PDE4 cAMP phosphodiesterase isoforms in mediating cross-talk between the cAMP and ERK signalling pathways

Biochemical Society transactions, 2003-12, Vol.31 (Pt 6), p.1186-1190

2003

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Keynote review: Phosphodiesterase-4 as a therapeutic target

Drug discovery today, 2005-11, Vol.10 (22), p.1503-1519

2005

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Phosphodiesterase isoforms in the pulmonary arterial circulation of the rat: changes in pulmonary hypertension

The Journal of pharmacology and experimental therapeutics, 1997-11, Vol.283 (2), p.619

1997

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Human phosphodiesterase 4D7 (PDE4D7) expression is increased in TMPRSS2-ERG-positive primary prostate cancer and independently adds to a reduced risk of post-surgical disease progression

British journal of cancer, 2015-11, Vol.113 (10), p.1502-1511

2015

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Tailoring cAMP-signalling responses through isoform multiplicity

Trends in Biochemical Sciences, 1997-06, Vol.22 (6), p.217-224

1997

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Adenosine 3',5'-Cyclic Monophosphate (cAMP)-Dependent Inhibition of IL-5 from Human T Lymphocytes Is Not Mediated by the cAMP-Dependent Protein Kinase A

The Journal of immunology (1950), 2001-08, Vol.167 (4), p.2074-2080

2001

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Cell-type specific integration of cross-talk between extracellular signal-regulated kinase and cAMP signaling

Molecular pharmacology, 2000-10, Vol.58 (4), p.659-668

2000

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mAKAP assembles a protein kinase A/PDE4 phosphodiesterase cAMP signaling module

The EMBO journal, 2001-04, Vol.20 (8), p.1921-1930

2001

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cAMP phosphodiesterase-4A1 (PDE4A1) has provided the paradigm for the intracellular targeting of phosphodiesterases, a process that underpins compartmentalized cAMP signalling

Biochemical Society transactions, 2006-08, Vol.34 (Pt 4), p.504-509

2006

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Engineered deletion of the unique N-terminal domain of the cyclic AMP-specific phosphodiesterase RD1 prevents plasma membrane association and the attainment of enhanced thermostability without altering its sensitivity to inhibition by rolipram

Biochemical journal, 1993-06, Vol.292 (3), p.677-686

1993

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cAMP-specific phosphodiesterase-4D5 (PDE4D5) provides a paradigm for understanding the unique non-redundant roles that PDE4 isoforms play in shaping compartmentalized cAMP cell signalling

Biochemical Society transactions, 2007-11, Vol.35 (Pt 5), p.938-941

2007

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Underpinning compartmentalised cAMP signalling through targeted cAMP breakdown

Trends in biochemical sciences (Amsterdam. Regular ed.), 2010-02, Vol.35 (2), p.91-100

Houslay, Miles D.

2010

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Identification, characterization and regional distribution in brain of RPDE-6 (RNPDE4A5), a novel splice variant of the PDE4A cyclic AMP phosphodiesterase family

Biochemical journal, 1995-09, Vol.310 ( Pt 3) (3), p.965-974

1995

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PDE4 associates with different scaffolding proteins: modulating interactions as treatment for certain diseases

Handbook of experimental pharmacology, 2008 (186), p.125

2008

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The RACK1 Signaling Scaffold Protein Selectively Interacts with the cAMP-specific Phosphodiesterase PDE4D5 Isoform

The Journal of biological chemistry, 1999-05, Vol.274 (21), p.14909-14917

1999

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Action of rolipram on specific PDE4 cAMP phosphodiesterase isoforms and on the phosphorylation of cAMP-response-element-binding protein (CREB) and p38 mitogen-activated protein (MAP) kinase in U937 monocytic cells

Biochemical journal, 2000-04, Vol.347 (Pt 2), p.571-578

2000

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Apremilast, a cAMP phosphodiesterase‐4 inhibitor, demonstrates anti‐inflammatory activity in vitro and in a model of psoriasis

The cAMP phosphodiesterase-4D7 (PDE4D7) is downregulated in androgen-independent prostate cancer cells and mediates proliferation by compartmentalising cAMP at the plasma membrane of VCaP prostate cancer cells

β-Arrestin 1 Inhibits the GTPase-Activating Protein Function of ARHGAP21, Promoting Activation of RhoA following Angiotensin II Type 1A Receptor Stimulation

The role of the PDE4D cAMP phosphodiesterase in the regulation of glucagon‐like peptide‐1 release

Phosphorylation of PDE4A5 by MAPKAPK2 attenuates fibrin degradation via p75 signalling

Disruption of the cyclic AMP phosphodiesterase-4 (PDE4)–HSP20 complex attenuates the β-agonist induced hypertrophic response in cardiac myocytes

FBXW7 regulates DISC1 stability via the ubiquitin-proteosome system

The psychiatric disease risk factors DISC1 and TNIK interact to regulate synapse composition and function

Epac and the high affinity rolipram binding conformer of PDE4 modulate neurite outgrowth and myelination using an in vitro spinal cord injury model

The role of ERK2 docking and phosphorylation of PDE4 cAMP phosphodiesterase isoforms in mediating cross-talk between the cAMP and ERK signalling pathways

Keynote review: Phosphodiesterase-4 as a therapeutic target

Phosphodiesterase isoforms in the pulmonary arterial circulation of the rat: changes in pulmonary hypertension

Human phosphodiesterase 4D7 (PDE4D7) expression is increased in TMPRSS2-ERG-positive primary prostate cancer and independently adds to a reduced risk of post-surgical disease progression

Tailoring cAMP-signalling responses through isoform multiplicity

Adenosine 3',5'-Cyclic Monophosphate (cAMP)-Dependent Inhibition of IL-5 from Human T Lymphocytes Is Not Mediated by the cAMP-Dependent Protein Kinase A

Cell-type specific integration of cross-talk between extracellular signal-regulated kinase and cAMP signaling

mAKAP assembles a protein kinase A/PDE4 phosphodiesterase cAMP signaling module

cAMP phosphodiesterase-4A1 (PDE4A1) has provided the paradigm for the intracellular targeting of phosphodiesterases, a process that underpins compartmentalized cAMP signalling

Engineered deletion of the unique N-terminal domain of the cyclic AMP-specific phosphodiesterase RD1 prevents plasma membrane association and the attainment of enhanced thermostability without altering its sensitivity to inhibition by rolipram

cAMP-specific phosphodiesterase-4D5 (PDE4D5) provides a paradigm for understanding the unique non-redundant roles that PDE4 isoforms play in shaping compartmentalized cAMP cell signalling

Underpinning compartmentalised cAMP signalling through targeted cAMP breakdown

Identification, characterization and regional distribution in brain of RPDE-6 (RNPDE4A5), a novel splice variant of the PDE4A cyclic AMP phosphodiesterase family

PDE4 associates with different scaffolding proteins: modulating interactions as treatment for certain diseases

The RACK1 Signaling Scaffold Protein Selectively Interacts with the cAMP-specific Phosphodiesterase PDE4D5 Isoform

Action of rolipram on specific PDE4 cAMP phosphodiesterase isoforms and on the phosphorylation of cAMP-response-element-binding protein (CREB) and p38 mitogen-activated protein (MAP) kinase in U937 monocytic cells

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