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Inhibiting the system xC−/glutathione axis selectively targets cancers with mutant-p53 accumulation

Nature communications, 2017-03, Vol.8 (1), p.14844-14844, Article 14844

2017

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Deregulation of MYCN, LIN28B and LET7 in a molecular subtype of aggressive high-grade serous ovarian cancers

PloS one, 2011-04, Vol.6 (4), p.e18064-e18064

2011

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Real-time visualization of perforin nanopore assembly

Nature nanotechnology, 2017-05, Vol.12 (5), p.467-473

2017

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IL6-STAT3-HIF Signaling and Therapeutic Response to the Angiogenesis Inhibitor Sunitinib in Ovarian Clear Cell Cancer

Clinical cancer research, 2011-04, Vol.17 (8), p.2538-2548

2011

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SFRP4 drives invasion in gastric cancer and is an early predictor of recurrence

Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association, 2021-05, Vol.24 (3), p.589-601

2021

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Functional-genetic dissection of HDAC dependencies in mouse lymphoid and myeloid malignancies

Blood, 2015-11, Vol.126 (21), p.2392-2403

2015

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Siah Proteins: Novel Drug Targets in the Ras and Hypoxia Pathways

Cancer research (Chicago, Ill.), 2009-12, Vol.69 (23), p.8835-8838

2009

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Foxp3 expression in macrophages associated with RENCA tumors in mice

PloS one, 2014-09, Vol.9 (9), p.e108670-e108670

2014

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A Binding Motif for Siah Ubiquitin Ligase

Proceedings of the National Academy of Sciences - PNAS, 2003-03, Vol.100 (6), p.3101-3106

2003

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Pits and CtBP Control Tissue Growth in Drosophila melanogaster with the Hippo Pathway Transcription Repressor Tgi

Genetics (Austin), 2020-05, Vol.215 (1), p.117-128

2020

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Regulation of perforin activation and pre‐synaptic toxicity through C‐terminal glycosylation

EMBO reports, 2017-10, Vol.18 (10), p.1775-1785

2017

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The Ubiquitin Ligase Component Siah1a Is Required for Completion of Meiosis I in Male Mice

Molecular and Cellular Biology, 2002-04, Vol.22 (7), p.2294-2303

2002

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Differential cleavage of viral polypeptides by allotypic variants of granzyme B skews immunity to mouse cytomegalovirus

Biochimica et biophysica acta. Proteins and proteomics, 2020-09, Vol.1868 (9), p.140457-140457, Article 140457

2020

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The ubiquitin ligase Siah is a novel regulator of Zeb1 in breast cancer

Oncotarget, 2015-01, Vol.6 (2), p.862-873

2015

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Relative Expression Levels Rather Than Specific Activity Plays the Major Role in Determining In Vivo AKT Isoform Substrate Specificity

Enzyme Research, 2011, Vol.2011, p.720985-18

2011

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Vascular Normalization by Loss of Siah2 Results in Increased Chemotherapeutic Efficacy

Cancer research (Chicago, Ill.), 2012-04, Vol.72 (7), p.1694-1704

2012

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Perforin activity and immune homeostasis: the common A91V polymorphism in perforin results in both presynaptic and postsynaptic defects in function

Blood, 2007-08, Vol.110 (4), p.1184-1190

2007

Volltextzugriff (PDF)

A phospho-proteomic screen identifies novel S6K1 and mTORC1 substrates revealing additional complexity in the signaling network regulating cell growth

Cellular signalling, 2011-08, Vol.23 (8), p.1338-1347

2011

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Elucidation of the Substrate Binding Site of Siah Ubiquitin Ligase

Structure (London), 2006-04, Vol.14 (4), p.695-701

2006

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Mammalian AMP-activated Protein Kinase Subfamily (∗)

The Journal of biological chemistry, 1996-01, Vol.271 (2), p.611-614

1996

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Posttranslational Modifications of the 5′-AMP-activated Protein Kinase β1 Subunit

The Journal of biological chemistry, 1997-09, Vol.272 (39), p.24475-24479

1997

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Phosphorylation at the Cyclin-dependent Kinases Site (Thr85) of Parathyroid Hormone-related Protein Negatively Regulates Its Nuclear Localization

The Journal of biological chemistry, 1999-06, Vol.274 (26), p.18559-18566

1999

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Siah ubiquitin ligase is structurally related to TRAF and modulates TNF-α signaling

Nature structural biology, 2002-01, Vol.9 (1), p.68-75

2002

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Isoform-specific Purification and Substrate Specificity of the 5′-AMP-activated Protein Kinase

The Journal of biological chemistry, 1996-11, Vol.271 (45), p.28445-28450

1996

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Structural basis of autoregulation of phenylalanine hydroxylase

Nature structural biology, 1999-05, Vol.6 (5), p.442-448

1999

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Inhibiting the system xC−/glutathione axis selectively targets cancers with mutant-p53 accumulation

Deregulation of MYCN, LIN28B and LET7 in a molecular subtype of aggressive high-grade serous ovarian cancers

Real-time visualization of perforin nanopore assembly

IL6-STAT3-HIF Signaling and Therapeutic Response to the Angiogenesis Inhibitor Sunitinib in Ovarian Clear Cell Cancer

SFRP4 drives invasion in gastric cancer and is an early predictor of recurrence

Functional-genetic dissection of HDAC dependencies in mouse lymphoid and myeloid malignancies

Siah Proteins: Novel Drug Targets in the Ras and Hypoxia Pathways

Foxp3 expression in macrophages associated with RENCA tumors in mice

A Binding Motif for Siah Ubiquitin Ligase

Pits and CtBP Control Tissue Growth in Drosophila melanogaster with the Hippo Pathway Transcription Repressor Tgi

Regulation of perforin activation and pre‐synaptic toxicity through C‐terminal glycosylation

The Ubiquitin Ligase Component Siah1a Is Required for Completion of Meiosis I in Male Mice

Differential cleavage of viral polypeptides by allotypic variants of granzyme B skews immunity to mouse cytomegalovirus

The ubiquitin ligase Siah is a novel regulator of Zeb1 in breast cancer

Relative Expression Levels Rather Than Specific Activity Plays the Major Role in Determining In Vivo AKT Isoform Substrate Specificity

Vascular Normalization by Loss of Siah2 Results in Increased Chemotherapeutic Efficacy

Perforin activity and immune homeostasis: the common A91V polymorphism in perforin results in both presynaptic and postsynaptic defects in function

A phospho-proteomic screen identifies novel S6K1 and mTORC1 substrates revealing additional complexity in the signaling network regulating cell growth

Elucidation of the Substrate Binding Site of Siah Ubiquitin Ligase

Mammalian AMP-activated Protein Kinase Subfamily (∗)

Posttranslational Modifications of the 5′-AMP-activated Protein Kinase β1 Subunit

Phosphorylation at the Cyclin-dependent Kinases Site (Thr85) of Parathyroid Hormone-related Protein Negatively Regulates Its Nuclear Localization

Siah ubiquitin ligase is structurally related to TRAF and modulates TNF-α signaling

Isoform-specific Purification and Substrate Specificity of the 5′-AMP-activated Protein Kinase

Structural basis of autoregulation of phenylalanine hydroxylase

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