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Incorporating Explicit Water Molecules and Ligand Conformation Stability in Machine-Learning Scoring Functions

Journal of chemical information and modeling, 2019-11, Vol.59 (11), p.4540-4549

2019

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Selective and noncovalent targeting of RAS mutants for inhibition and degradation

Nature communications, 2021-05, Vol.12 (1), p.2656-2656, Article 2656

2021

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Recent Development of Novel HDAC6 Isoform-selective Inhibitors

Current medicinal chemistry, 2021-01, Vol.28 (21), p.4133-4151

2021

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Targeting active RAS with molecular glue

Pharmaceutical Science Advances, 2024-12, Vol.2, p.100047, Article 100047

2024

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Recent Applications of Benzimidazole as a Privileged Scaffold in Drug Discovery

Mini reviews in medicinal chemistry, 2021-01, Vol.21 (11), p.1367-1379

2021

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Structure, Function and Modulation of Striatal-enriched Protein Tyrosine Phosphatase (STEP)

Current medicinal chemistry, 2021-01, Vol.28 (37), p.7714-7728

2021

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Recent Advances in Small Molecule PROTACs for the Treatment of Cancer

Current medicinal chemistry, 2021-01, Vol.28 (24), p.4893-4909

2021

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Targeting histone deacetylases for cancer therapy: Trends and challenges

Acta pharmaceutica Sinica. B, 2023-06, Vol.13 (6), p.2425-2463

2023

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How to Improve Docking Accuracy of AutoDock4.2: A Case Study Using Different Electrostatic Potentials

Journal of chemical information and modeling, 2013-01, Vol.53 (1), p.188-200

2013

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New techniques and strategies in drug discovery

Chinese chemical letters, 2020-07, Vol.31 (7), p.1695-1708

2020

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Strategies to overcome drug resistance using SHP2 inhibitors

Acta pharmaceutica Sinica. B, 2021-12, Vol.11 (12), p.3908-3924

2021

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Structural basis of human SNAPc recognizing proximal sequence element of snRNA promoter

Nature communications, 2022-11, Vol.13 (1), p.6871-6871, Article 6871

2022

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Enhancing the Sensitivity of Pharmacophore-Based Virtual Screening by Incorporating Customized ZBG Features: A Case Study Using Histone Deacetylase 8

Journal of chemical information and modeling, 2015-04, Vol.55 (4), p.861-871

2015

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Recent Development of CDK2 Inhibitors as Anticancer Drugs: An Update (2015–2023)

Pharmaceutical fronts, 2024-09, Vol.6 (3), p.e195-e220

2024

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Improved antiproliferative activity of 1,3,4-thiadiazole-containing histone deacetylase (HDAC) inhibitors by introduction of the heteroaromatic surface recognition motif

Bioorganic & medicinal chemistry, 2014-11, Vol.22 (21), p.5766-5775

2014

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Structure-Based Design of 2-Aminopurine Derivatives as CDK2 Inhibitors for Triple-Negative Breast Cancer

Frontiers in pharmacology, 2022-05, Vol.13, p.864342-864342

2022

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Development of QSRR model for hydroxamic acids using PCA-GA-BP algorithm incorporated with molecular interaction-based features

Frontiers in chemistry, 2022-11, Vol.10, p.1056701-1056701

2022

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Recent Advances in the Development of Selective Mcl-1 Inhibitors for the Treatment of Cancer (2017-Present)

Recent patents on anti-cancer drug discovery, 2020-01, Vol.15 (4), p.306-320

2020

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Design, synthesis and preliminary bioactivity studies of 1,3,4-thiadiazole hydroxamic acid derivatives as novel histone deacetylase inhibitors

Bioorganic & medicinal chemistry, 2012-06, Vol.20 (12), p.3865-3872

2012

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Dual Inhibitors Targeting DNA and Histone Deacetylases

Pharmaceutical fronts, 2020-06, Vol.2 (2), p.e88-e93

2020

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High-performance liquid chromatographic enantioseparation of 3,5-disubstituted hydantoins analogs and temperature-induced reversals of elution orders on a polysaccharide-based chiral stationary phase

Journal of Chromatography A, 2014-08, Vol.1355, p.291-295

2014

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Antagonists of IAP proteins: novel anti-tumor agents

Current medicinal chemistry, 2014-01, Vol.21 (34), p.3877-3892

2014

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HBV inhibits LPS-induced NLRP3 inflammasome activation and IL-1β production via suppressing the NF-κB pathway and ROS production

Journal of hepatology, 2017-04, Vol.66 (4), p.693-702

2017

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Recent advances in the development of allosteric protein tyrosine phosphatase inhibitors for drug discovery

Medicinal research reviews, 2022-05, Vol.42 (3), p.1064-1110

2022

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Resveratrol serves as a protein-substrate interaction stabilizer in human SIRT1 activation

Scientific reports, 2016-11, Vol.6 (1), p.38186-38186, Article 38186

2016

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Incorporating Explicit Water Molecules and Ligand Conformation Stability in Machine-Learning Scoring Functions

Selective and noncovalent targeting of RAS mutants for inhibition and degradation

Recent Development of Novel HDAC6 Isoform-selective Inhibitors

Targeting active RAS with molecular glue

Recent Applications of Benzimidazole as a Privileged Scaffold in Drug Discovery

Structure, Function and Modulation of Striatal-enriched Protein Tyrosine Phosphatase (STEP)

Recent Advances in Small Molecule PROTACs for the Treatment of Cancer

Targeting histone deacetylases for cancer therapy: Trends and challenges

How to Improve Docking Accuracy of AutoDock4.2: A Case Study Using Different Electrostatic Potentials

New techniques and strategies in drug discovery

Strategies to overcome drug resistance using SHP2 inhibitors

Structural basis of human SNAPc recognizing proximal sequence element of snRNA promoter

Enhancing the Sensitivity of Pharmacophore-Based Virtual Screening by Incorporating Customized ZBG Features: A Case Study Using Histone Deacetylase 8

Recent Development of CDK2 Inhibitors as Anticancer Drugs: An Update (2015–2023)

Improved antiproliferative activity of 1,3,4-thiadiazole-containing histone deacetylase (HDAC) inhibitors by introduction of the heteroaromatic surface recognition motif

Structure-Based Design of 2-Aminopurine Derivatives as CDK2 Inhibitors for Triple-Negative Breast Cancer

Development of QSRR model for hydroxamic acids using PCA-GA-BP algorithm incorporated with molecular interaction-based features

Recent Advances in the Development of Selective Mcl-1 Inhibitors for the Treatment of Cancer (2017-Present)

Design, synthesis and preliminary bioactivity studies of 1,3,4-thiadiazole hydroxamic acid derivatives as novel histone deacetylase inhibitors

Dual Inhibitors Targeting DNA and Histone Deacetylases

High-performance liquid chromatographic enantioseparation of 3,5-disubstituted hydantoins analogs and temperature-induced reversals of elution orders on a polysaccharide-based chiral stationary phase

Antagonists of IAP proteins: novel anti-tumor agents

HBV inhibits LPS-induced NLRP3 inflammasome activation and IL-1β production via suppressing the NF-κB pathway and ROS production

Recent advances in the development of allosteric protein tyrosine phosphatase inhibitors for drug discovery

Resveratrol serves as a protein-substrate interaction stabilizer in human SIRT1 activation

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