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Structure-Based Design of a Novel Series of Potent, Selective Inhibitors of the Class I Phosphatidylinositol 3-Kinases

Journal of medicinal chemistry, 2012-06, Vol.55 (11), p.5188-5219

2012

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Discovery of Selective Pituitary Adenylate Cyclase 1 Receptor (PAC1R) Antagonist Peptides Potent in a Maxadilan/PACAP38-Induced Increase in Blood Flow Pharmacodynamic Model

Journal of medicinal chemistry, 2021-03, Vol.64 (6), p.3427-3438

2021

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Discovery and Structure-Guided Optimization of Diarylmethanesulfonamide Disrupters of Glucokinase–Glucokinase Regulatory Protein (GK–GKRP) Binding: Strategic Use of a N → S (nN → σS–X) Interaction for Conformational Constraint

Journal of medicinal chemistry, 2015-12, Vol.58 (24), p.9663-9679

2015

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Azole-based inhibitors of AKT/PKB for the treatment of cancer

Bioorganic & medicinal chemistry letters, 2010-03, Vol.20 (5), p.1559-1564

2010

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Small Molecule Disruptors of the Glucokinase–Glucokinase Regulatory Protein Interaction: 5. A Novel Aryl Sulfone Series, Optimization Through Conformational Analysis

Journal of medicinal chemistry, 2015-06, Vol.58 (11), p.4462-4482

2015

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Stereocontrolled Synthesis of Triazacyclopenta[cd]pentalenes by Intramolecular 1,3-Dipolar Cycloaddition Reactions of Azomethine Imines

Journal of organic chemistry, 2002-11, Vol.67 (22), p.7880-7883

2002

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Small Molecule Disruptors of the Glucokinase–Glucokinase Regulatory Protein Interaction: 4. Exploration of a Novel Binding Pocket

Journal of medicinal chemistry, 2014-07, Vol.57 (14), p.5949-5964

2014

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Cytochrome P450-Mediated Epoxidation of 2-Aminothiazole-Based AKT Inhibitors: Identification of Novel GSH Adducts and Reduction of Metabolic Activation through Structural Changes Guided by in Silico and in Vitro Screening

Chemical research in toxicology, 2010-03, Vol.23 (3), p.653-663

2010

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Phosphoinositide-3-kinase inhibitors: evaluation of substituted alcohols as replacements for the piperazine sulfonamide portion of AMG 511

Bioorganic & medicinal chemistry letters, 2014-12, Vol.24 (24), p.5630-5634

2014

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Total Synthesis of Dumsin. 1. Retrosynthetic Strategy and the Elaboration of Key Intermediates from (−)-Bornyl Acetate

Journal of organic chemistry, 2003-09, Vol.68 (18), p.6905-6918

2003

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Formal Syntheses of (±)-Methylenomycins A and B

Journal of the Chinese Chemical Society (Taipei), 2000-02, Vol.47 (1), p.77-83

2000

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Photochemistry of Substituted 4,4-Dimethoxy-2,5-Cyclohexadienones

Journal of the Chinese Chemical Society (Taipei), 1998-02, Vol.45 (1), p.1-12

1998

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Photochemistry of alkylated 4,4-dimethoxy-2,5-cyclohexadienones in methanol. Synthesis of methyl ester of (±)-desepoxy-2,5-didehydromethylenomycin A

Tetrahedron letters, 1992-04, Vol.33 (16), p.2155-2158

1992

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Abstract LB318: SB-4826, a first-in-class oral, covalent inhibitor of SUMO E1 that induces IFN signaling and inhibits tumor growth as monotherapy and in combination with immune checkpoint blockade

Cancer research (Chicago, Ill.), 2023-04, Vol.83 (8_Supplement), p.LB318-LB318

2023

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Abstract 2861: Validation of PERK as an oncology target: A role for the unfolded protein response in cancer

Cancer research (Chicago, Ill.), 2016-07, Vol.76 (14_Supplement), p.2861-2861

2016

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Efficient stereocontrolled synthesis of the ABC subunit of dumsin

Tetrahedron letters, 1994-12, Vol.35 (49), p.9153-9156

1994

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Correction to Selective Class I Phosphoinositide 3‑Kinase Inhibitors: Optimization of a Series of Pyridyltriazines Leading to the Identification of a Clinical Candidate, AMG 511

Journal of medicinal chemistry, 2012-10, Vol.55 (20), p.8975-8975

2012

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Heteroatomic Effects on the Reducibility of C-2 Carbinol Centers in 6-Ethoxy-3,6-dihydropyrans and -thiopyrans

Journal of organic chemistry, 1999-05, Vol.64 (10), p.3783-3786

1999

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A synthetic approach toward the potent antifeedant dumsin

Hong, Fang-Tsao

1998

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M1 macrophages decrease in the deciduae from normal pregnancies but not from spontaneous abortions or unexplained recurrent spontaneous abortions

Journal of the Formosan Medical Association, 2018-03, Vol.117 (3), p.204-211

2018

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Structure-Based Design of a Novel Series of Potent, Selective Inhibitors of the Class I Phosphatidylinositol 3-Kinases

Discovery of Selective Pituitary Adenylate Cyclase 1 Receptor (PAC1R) Antagonist Peptides Potent in a Maxadilan/PACAP38-Induced Increase in Blood Flow Pharmacodynamic Model

Discovery and Structure-Guided Optimization of Diarylmethanesulfonamide Disrupters of Glucokinase–Glucokinase Regulatory Protein (GK–GKRP) Binding: Strategic Use of a N → S (nN → σS–X) Interaction for Conformational Constraint

Azole-based inhibitors of AKT/PKB for the treatment of cancer

Small Molecule Disruptors of the Glucokinase–Glucokinase Regulatory Protein Interaction: 5. A Novel Aryl Sulfone Series, Optimization Through Conformational Analysis

Stereocontrolled Synthesis of Triazacyclopenta[cd]pentalenes by Intramolecular 1,3-Dipolar Cycloaddition Reactions of Azomethine Imines

Small Molecule Disruptors of the Glucokinase–Glucokinase Regulatory Protein Interaction: 2. Leveraging Structure-Based Drug Design to Identify Analogues with Improved Pharmacokinetic Profiles

Selective Class I Phosphoinositide 3‑Kinase Inhibitors: Optimization of a Series of Pyridyltriazines Leading to the Identification of a Clinical Candidate, AMG 511

Small Molecule Disruptors of the Glucokinase–Glucokinase Regulatory Protein Interaction: 4. Exploration of a Novel Binding Pocket

Cytochrome P450-Mediated Epoxidation of 2-Aminothiazole-Based AKT Inhibitors: Identification of Novel GSH Adducts and Reduction of Metabolic Activation through Structural Changes Guided by in Silico and in Vitro Screening

Phosphoinositide-3-kinase inhibitors: evaluation of substituted alcohols as replacements for the piperazine sulfonamide portion of AMG 511

Oxopyrido[2,3‑d]pyrimidines as Covalent L858R/T790M Mutant Selective Epidermal Growth Factor Receptor (EGFR) Inhibitors

Total Synthesis of Dumsin. 1. Retrosynthetic Strategy and the Elaboration of Key Intermediates from (−)-Bornyl Acetate

Formal Syntheses of (±)-Methylenomycins A and B

Photochemistry of Substituted 4,4-Dimethoxy-2,5-Cyclohexadienones

Photochemistry of alkylated 4,4-dimethoxy-2,5-cyclohexadienones in methanol. Synthesis of methyl ester of (±)-desepoxy-2,5-didehydromethylenomycin A

Abstract LB318: SB-4826, a first-in-class oral, covalent inhibitor of SUMO E1 that induces IFN signaling and inhibits tumor growth as monotherapy and in combination with immune checkpoint blockade

Abstract 2861: Validation of PERK as an oncology target: A role for the unfolded protein response in cancer

Efficient stereocontrolled synthesis of the ABC subunit of dumsin

Correction to Selective Class I Phosphoinositide 3‑Kinase Inhibitors: Optimization of a Series of Pyridyltriazines Leading to the Identification of a Clinical Candidate, AMG 511

Heteroatomic Effects on the Reducibility of C-2 Carbinol Centers in 6-Ethoxy-3,6-dihydropyrans and -thiopyrans

A synthetic approach toward the potent antifeedant dumsin

M1 macrophages decrease in the deciduae from normal pregnancies but not from spontaneous abortions or unexplained recurrent spontaneous abortions

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