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Discovery of Potent and Selective p53-MDM2 Protein-Protein Interaction Inhibitors as Anticancer Drugs

Chimia, 2017-10, Vol.71 (10), p.716

Holzer, Philipp

2017

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p53 dynamics vary between tissues and are linked with radiation sensitivity

Nature communications, 2021-02, Vol.12 (1), p.898-11, Article 898

2021

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Discovery of a Dihydroisoquinolinone Derivative (NVP-CGM097): A Highly Potent and Selective MDM2 Inhibitor Undergoing Phase 1 Clinical Trials in p53wt Tumors

Journal of medicinal chemistry, 2015-08, Vol.58 (16), p.6348-6358

2015

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Dose and Schedule Determine Distinct Molecular Mechanisms Underlying the Efficacy of the p53-MDM2 Inhibitor HDM201

Cancer research (Chicago, Ill.), 2018-11, Vol.78 (21), p.6257-6267

2018

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Structural States of Hdm2 and HdmX: X‐ray Elucidation of Adaptations and Binding Interactions for Different Chemical Compound Classes

ChemMedChem, 2019-07, Vol.14 (14), p.1305-1314

2019

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The small molecule specific EphB4 kinase inhibitor NVP-BHG712 inhibits VEGF driven angiogenesis

Angiogenesis (London), 2010-09, Vol.13 (3), p.259-267

2010

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Discovery of Novel Dot1L Inhibitors through a Structure-Based Fragmentation Approach

ACS medicinal chemistry letters, 2016-08, Vol.7 (8), p.735-740

2016

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Discovery of Potent, Selective, and Structurally Novel Dot1L Inhibitors by a Fragment Linking Approach

ACS medicinal chemistry letters, 2017-03, Vol.8 (3), p.338-343

2017

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Abstract 1239: NVP-HDM201: Biochemical and biophysical profile of a novel highly potent and selective PPI inhibitor of p53-Mdm2

Cancer research (Chicago, Ill.), 2016-07, Vol.76 (14_Supplement), p.1239-1239

2016

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Theory of photoionization-induced blueshift of ultrashort solitons in gas-filled hollow-core photonic crystal fibers

Physical review letters, 2011-11, Vol.107 (20), p.203902-203902, Article 203902

2011

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Click chemistry in materials synthesis. 1. Adhesive polymers from copper-catalyzed azide-alkyne cycloaddition

Journal of polymer science. Part A, Polymer chemistry, 2004-09, Vol.42 (17), p.4392-4403

2004

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Heavy-ion-induced desorption yields of cryogenic surfaces bombarded with 1.4 MeV / u xenon ions

Physical review special topics. PRST-AB. Accelerators and beams, 2013-08, Vol.16 (8), p.083201, Article 083201

2013

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Discovery of a novel class of highly potent inhibitors of the p53–MDM2 interaction by structure-based design starting from a conformational argument

Bioorganic & medicinal chemistry letters, 2016-10, Vol.26 (19), p.4837-4841

2016

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Synthesis of the Potent, Selective, and Efficacious β‑Secretase (BACE1) Inhibitor NB-360

Journal of medicinal chemistry, 2021-04, Vol.64 (8), p.4677-4696

2021

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DCAF1-based PROTACs with activity against clinically validated targets overcoming intrinsic- and acquired-degrader resistance

Nature communications, 2024-01, Vol.15 (1), p.275-19, Article 275

2024

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Discovery of dihydroisoquinolinone derivatives as novel inhibitors of the p53–MDM2 interaction with a distinct binding mode

Bioorganic & medicinal chemistry letters, 2015-09, Vol.25 (17), p.3621-3625

2015

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In vitro and in vivo characterization of a novel, highly potent p53-MDM2 inhibitor

Bioorganic & medicinal chemistry letters, 2018-11, Vol.28 (20), p.3404-3408

2018

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Discovery of New Binders for DCAF1, an Emerging Ligase Target in the Targeted Protein Degradation Field

ACS medicinal chemistry letters, 2023-07, Vol.14 (7), p.949-954

2023

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Author Correction: DCAF1-based PROTACs with activity against clinically validated targets overcoming intrinsic- and acquired-degrader resistance

Nature communications, 2024-08, Vol.15 (1), p.7109-5

2024

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Discovery of amino-1,4-oxazines as potent BACE-1 inhibitors

Bioorganic & medicinal chemistry letters, 2018-07, Vol.28 (12), p.2195-2200

2018

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Podocyte EphB4 signaling helps recovery from glomerular injury

Kidney international, 2012-06, Vol.81 (12), p.1212-1225

2012

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Front Cover: Structural States of Hdm2 and HdmX: X‐ray Elucidation of Adaptations and Binding Interactions for Different Chemical Compound Classes (ChemMedChem 14/2019)

ChemMedChem, 2019-07, Vol.14 (14), p.1304-1304

2019

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Abstract 4855: Discovery of NVP-HDM201 - First disclosure of a Next-Generation Mdm2 inhibitor with superior characteristics

Cancer research (Chicago, Ill.), 2016-07, Vol.76 (14_Supplement), p.4855-4855

2016

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Discovery of Potent and Selective p53-MDM2 Protein-Protein Interaction Inhibitors as Anticancer Drugs

p53 dynamics vary between tissues and are linked with radiation sensitivity

Discovery of a Dihydroisoquinolinone Derivative (NVP-CGM097): A Highly Potent and Selective MDM2 Inhibitor Undergoing Phase 1 Clinical Trials in p53wt Tumors

Dose and Schedule Determine Distinct Molecular Mechanisms Underlying the Efficacy of the p53-MDM2 Inhibitor HDM201

A distinct p53 target gene set predicts for response to the selective p53-HDM2 inhibitor NVP-CGM097

Structural States of Hdm2 and HdmX: X‐ray Elucidation of Adaptations and Binding Interactions for Different Chemical Compound Classes

The small molecule specific EphB4 kinase inhibitor NVP-BHG712 inhibits VEGF driven angiogenesis

Discovery of Novel Dot1L Inhibitors through a Structure-Based Fragmentation Approach

Discovery of Potent, Selective, and Structurally Novel Dot1L Inhibitors by a Fragment Linking Approach

Correction: A distinct p53 target gene set predicts for response to the selective p53-HDM2 inhibitor NVP-CGM097

Abstract 1239: NVP-HDM201: Biochemical and biophysical profile of a novel highly potent and selective PPI inhibitor of p53-Mdm2

Theory of photoionization-induced blueshift of ultrashort solitons in gas-filled hollow-core photonic crystal fibers

Click chemistry in materials synthesis. 1. Adhesive polymers from copper-catalyzed azide-alkyne cycloaddition

Heavy-ion-induced desorption yields of cryogenic surfaces bombarded with 1.4 MeV / u xenon ions

Discovery of a novel class of highly potent inhibitors of the p53–MDM2 interaction by structure-based design starting from a conformational argument

Synthesis of the Potent, Selective, and Efficacious β‑Secretase (BACE1) Inhibitor NB-360

DCAF1-based PROTACs with activity against clinically validated targets overcoming intrinsic- and acquired-degrader resistance

Discovery of dihydroisoquinolinone derivatives as novel inhibitors of the p53–MDM2 interaction with a distinct binding mode

In vitro and in vivo characterization of a novel, highly potent p53-MDM2 inhibitor

Discovery of New Binders for DCAF1, an Emerging Ligase Target in the Targeted Protein Degradation Field

Author Correction: DCAF1-based PROTACs with activity against clinically validated targets overcoming intrinsic- and acquired-degrader resistance

Discovery of amino-1,4-oxazines as potent BACE-1 inhibitors

Podocyte EphB4 signaling helps recovery from glomerular injury

Front Cover: Structural States of Hdm2 and HdmX: X‐ray Elucidation of Adaptations and Binding Interactions for Different Chemical Compound Classes (ChemMedChem 14/2019)

Abstract 4855: Discovery of NVP-HDM201 - First disclosure of a Next-Generation Mdm2 inhibitor with superior characteristics

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