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Oxidized DNA fragments exit mitochondria via mPTP- and VDAC-dependent channels to activate NLRP3 inflammasome and interferon signaling

Immunity (Cambridge, Mass.), 2022-08, Vol.55 (8), p.1370-1385.e8

2022

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Monogenic autoinflammatory disorders: Conceptual overview, phenotype, and clinical approach

Journal of allergy and clinical immunology, 2020-11, Vol.146 (5), p.925-937

2020

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Inflammasome activation leads to Caspase-1-dependent mitochondrial damage and block of mitophagy

Proceedings of the National Academy of Sciences - PNAS, 2014-10, Vol.111 (43), p.15514-15519

2014

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Hepatocyte pyroptosis and release of inflammasome particles induce stellate cell activation and liver fibrosis

Journal of hepatology, 2021-01, Vol.74 (1), p.156-167

2021

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NF-κB Restricts Inflammasome Activation via Elimination of Damaged Mitochondria

Cell, 2016-02, Vol.164 (5), p.896-910

2016

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NLRP3 inflammasome activation results in hepatocyte pyroptosis, liver inflammation, and fibrosis in mice

Hepatology (Baltimore, Md.), 2014-03, Vol.59 (3), p.898-910

2014

Volltextzugriff (PDF)

The Inflammasomes and Autoinflammatory Syndromes

Annual review of pathology, 2015-01, Vol.10 (1), p.395-424

2015

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NLRP3 inflammasome activation is required for fibrosis development in NAFLD

Journal of molecular medicine (Berlin, Germany), 2014-10, Vol.92 (10), p.1069-1082

2014

Volltextzugriff (PDF)

The role of the inflammasome in patients with autoinflammatory diseases

Journal of allergy and clinical immunology, 2016-07, Vol.138 (1), p.3-14

2016

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Inflammasome-mediated dysbiosis regulates progression of NAFLD and obesity

Nature (London), 2012-02, Vol.482 (7384), p.179-185

2012

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Neutrophils: New insights and open questions

Science immunology, 2018-12, Vol.3 (30)

2018

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NLRP3 inflammasome driven liver injury and fibrosis: Roles of IL‐17 and TNF in mice

Hepatology (Baltimore, Md.), 2018-02, Vol.67 (2), p.736-749

2018

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TNF regulates transcription of NLRP3 inflammasome components and inflammatory molecules in cryopyrinopathies

The Journal of clinical investigation, 2017-12, Vol.127 (12), p.4488-4497

2017

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Diagnostic criteria for cryopyrin-associated periodic syndrome (CAPS)

Annals of the rheumatic diseases, 2017-06, Vol.76 (6), p.942

2017

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NLR Family Pyrin Domain‐Containing 3 Inflammasome Activation in Hepatic Stellate Cells Induces Liver Fibrosis in Mice

Hepatology (Baltimore, Md.), 2019-02, Vol.69 (2), p.845-859

2019

Volltextzugriff (PDF)

Glyburide inhibits the Cryopyrin/Nalp3 inflammasome

The Journal of cell biology, 2009-10, Vol.187 (1), p.61-70

2009

Volltextzugriff (PDF)

The PYRIN Domain-only Protein POP1 Inhibits Inflammasome Assembly and Ameliorates Inflammatory Disease

Immunity (Cambridge, Mass.), 2015-08, Vol.43 (2), p.264-276

2015

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Divergence of IL-1, IL-18, and cell death in NLRP3 inflammasomopathies

The Journal of clinical investigation, 2013-11, Vol.123 (11), p.4695-4705

2013

Volltextzugriff (PDF)

GSDMB induces an asthma phenotype characterized by increased airway responsiveness and remodeling without lung inflammation

Proceedings of the National Academy of Sciences - PNAS, 2016-11, Vol.113 (46), p.13132-13137

2016

Volltextzugriff (PDF)

Neutrophil-specific gain-of-function mutations in Nlrp3 promote development of cryopyrin-associated periodic syndrome

The Journal of experimental medicine, 2021-10, Vol.218 (10)

2021

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ORMDL3 transgenic mice have increased airway remodeling and airway responsiveness characteristic of asthma

The Journal of immunology (1950), 2014-04, Vol.192 (8), p.3475-3487

2014

Volltextzugriff (PDF)

IL-1 and autoinflammatory disease: biology, pathogenesis and therapeutic targeting

Nature reviews. Rheumatology, 2022-08, Vol.18 (8), p.448-463

2022

Volltextzugriff (PDF)

Therapy of autoinflammatory syndromes

Journal of allergy and clinical immunology, 2009-12, Vol.124 (6), p.1129-1138

Hoffman, Hal M., MD

2009

Volltextzugriff (PDF)

ORMDL3 is an inducible lung epithelial gene regulating metalloproteases, chemokines, OAS, and ATF6

Proceedings of the National Academy of Sciences - PNAS, 2012-10, Vol.109 (41), p.16648-16653

2012

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The role of IL-1 in adipose browning and muscle wasting in CKD-associated cachexia

Scientific reports, 2021-07, Vol.11 (1), p.15141-15141, Article 15141

2021

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Oxidized DNA fragments exit mitochondria via mPTP- and VDAC-dependent channels to activate NLRP3 inflammasome and interferon signaling

Monogenic autoinflammatory disorders: Conceptual overview, phenotype, and clinical approach

Inflammasome activation leads to Caspase-1-dependent mitochondrial damage and block of mitophagy

Hepatocyte pyroptosis and release of inflammasome particles induce stellate cell activation and liver fibrosis

NF-κB Restricts Inflammasome Activation via Elimination of Damaged Mitochondria

NLRP3 inflammasome activation results in hepatocyte pyroptosis, liver inflammation, and fibrosis in mice

The Inflammasomes and Autoinflammatory Syndromes

NLRP3 inflammasome activation is required for fibrosis development in NAFLD

The role of the inflammasome in patients with autoinflammatory diseases

Inflammasome-mediated dysbiosis regulates progression of NAFLD and obesity

Neutrophils: New insights and open questions

NLRP3 inflammasome driven liver injury and fibrosis: Roles of IL‐17 and TNF in mice

TNF regulates transcription of NLRP3 inflammasome components and inflammatory molecules in cryopyrinopathies

Diagnostic criteria for cryopyrin-associated periodic syndrome (CAPS)

NLR Family Pyrin Domain‐Containing 3 Inflammasome Activation in Hepatic Stellate Cells Induces Liver Fibrosis in Mice

Glyburide inhibits the Cryopyrin/Nalp3 inflammasome

The PYRIN Domain-only Protein POP1 Inhibits Inflammasome Assembly and Ameliorates Inflammatory Disease

Divergence of IL-1, IL-18, and cell death in NLRP3 inflammasomopathies

GSDMB induces an asthma phenotype characterized by increased airway responsiveness and remodeling without lung inflammation

Neutrophil-specific gain-of-function mutations in Nlrp3 promote development of cryopyrin-associated periodic syndrome

ORMDL3 transgenic mice have increased airway remodeling and airway responsiveness characteristic of asthma

IL-1 and autoinflammatory disease: biology, pathogenesis and therapeutic targeting

Therapy of autoinflammatory syndromes

ORMDL3 is an inducible lung epithelial gene regulating metalloproteases, chemokines, OAS, and ATF6

The role of IL-1 in adipose browning and muscle wasting in CKD-associated cachexia

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