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Genetic Polymorphisms and in Vitro Functional Characterization of CYP2C8, CYP2C9, and CYP2C19 Allelic Variants

Biological and Pharmaceutical Bulletin, 2016/11/01, Vol.39(11), pp.1748-1759

Hiratsuka, Masahiro

2016

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In Vitro Assessment of the Allelic Variants of Cytochrome P450

DRUG METABOLISM AND PHARMACOKINETICS, 2012, Vol.27 (1), p.68-84

Hiratsuka, Masahiro

2012

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An optimized prediction framework to assess the functional impact of pharmacogenetic variants

The pharmacogenomics journal, 2019-04, Vol.19 (2), p.115-126

2019

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Determination of novel CYP2D6 haplotype using the targeted sequencing followed by the long-read sequencing and the functional characterization in the Japanese population

Journal of human genetics, 2021-02, Vol.66 (2), p.139-149

2021

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Inhibition of thymic stromal lymphopoietin production by FK3453

Journal of pharmacological sciences, 2022-08, Vol.149 (4), p.198-204

2022

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High false-negative proportion of intraoperative histological examination as a serious problem for clinical application of sentinel node biopsy for early gastric cancer: final results of the Japan Clinical Oncology Group multicenter trial JCOG0302

Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association, 2014-04, Vol.17 (2), p.316-323

2014

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Heterologous expression of high-activity cytochrome P450 in mammalian cells

Scientific reports, 2020-08, Vol.10 (1), p.14193, Article 14193

2020

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Novel copy-number variations in pharmacogenes contribute to interindividual differences in drug pharmacokinetics

Genetics in medicine, 2018-06, Vol.20 (6), p.622-629

2018

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Development of a Simultaneous Liquid Chromatography-Tandem Mass Spectrometry Analytical Method for Urinary Endogenous Substrates and Metabolites for Predicting Cytochrome P450 3A4 Activity

Biological and Pharmaceutical Bulletin, 2023/03/01, Vol.46(3), pp.455-463

2023

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Structural Impact Assessment of Cytochrome P450 2A13 Polymorphisms Using Molecular Dynamics Simulations

Biological and Pharmaceutical Bulletin, 2024/03/13, Vol.47(3), pp.620-628

2024

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Hypoxia inhibits TNF-α-induced TSLP expression in keratinocytes

PloS one, 2019-11, Vol.14 (11), p.e0224705-e0224705

2019

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Variants of Flavin-Containing Monooxygenase 3 Found in Subjects in an Updated Database of Genome Resources

Drug metabolism and disposition, 2023-07, Vol.51 (7), p.884-891

2023

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Hypoxia-inducible factor prolyl hydroxylase inhibitors suppressed thymic stromal lymphopoietin production and allergic responses in a mouse air-pouch-type ovalbumin sensitization model

International immunopharmacology, 2023-05, Vol.118, p.110127-110127, Article 110127

2023

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jMorp: Japanese Multi-Omics Reference Panel update report 2023

Nucleic acids research, 2024-01, Vol.52 (D1), p.D622-D632

2024

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Progress Report of the Tohoku Medical Megabank Community-based Cohort Study: Study Profile of the Repeated Center-based Survey During Second Period in Miyagi Prefecture

Journal of Epidemiology, 2024/09/05, Vol.34(9), pp.434-443

2024

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Structural investigation of pathogenic variants in dihydropyrimidinase using molecular dynamics simulations

Journal of molecular graphics & modelling, 2022-12, Vol.117, p.108288, Article 108288

2022

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Rare but impaired flavin-containing monooxygenase 3 (FMO3) variants reported in a recently updated Japanese mega-databank of genome resources

Drug metabolism and pharmacokinetics, 2024-04, Vol.55, p.100539-100539, Article 100539

2024

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Lactate released from human fibroblasts enhances Ni elution from Ni plate

Toxicology (Amsterdam), 2021-04, Vol.453, p.152723, Article 152723

2021

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Validation of a genotyping technique for a surrogate marker of HLA-B58:01 for allopurinol-induced Stevens–Johnson syndrome and toxic epidermal necrolysis in the Japanese population

Drug metabolism and pharmacokinetics, 2023-04, Vol.49, p.100495, Article 100495

2023

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Genetic variants of flavin-containing monooxygenase 3 (FMO3) in Japanese subjects identified by phenotyping for trimethylaminuria and found in a database of genome resources

Drug metabolism and pharmacokinetics, 2021-06, Vol.38, p.100387, Article 100387

2021

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Functional Characterization of 21 Allelic Variants of Dihydropyrimidine Dehydrogenase Identified in 1070 Japanese Individuals

Drug metabolism and disposition, 2018-08, Vol.46 (8), p.1083-1090

2018

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All- Trans Retinoic Acid Enhances Antibody Production by Inducing the Expression of Thymic Stromal Lymphopoietin Protein

The Journal of immunology (1950), 2018-04, Vol.200 (8), p.2670-2676

2018

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Functional characterization of 50 CYP2D6 allelic variants by assessing primaquine 5-hydroxylation

Drug metabolism and pharmacokinetics, 2018-12, Vol.33 (6), p.250-257

2018

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Functional characterization of 17 CYP2D6 allelic variants (CYP2D6.2, 10, 14A-B, 18, 27, 36, 39, 47-51, 53-55, and 57)

Drug metabolism and disposition, 2008-12, Vol.36 (12), p.2460-2467

2008

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Functional Characterization of 12 Dihydropyrimidinase Allelic Variants in Japanese Individuals for the Prediction of 5-Fluorouracil Treatment-Related Toxicity

Drug metabolism and disposition, 2023-02, Vol.51 (2), p.165-173

2023

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Genetic Polymorphisms and in Vitro Functional Characterization of CYP2C8, CYP2C9, and CYP2C19 Allelic Variants

In Vitro Assessment of the Allelic Variants of Cytochrome P450

An optimized prediction framework to assess the functional impact of pharmacogenetic variants

Determination of novel CYP2D6 haplotype using the targeted sequencing followed by the long-read sequencing and the functional characterization in the Japanese population

Inhibition of thymic stromal lymphopoietin production by FK3453

High false-negative proportion of intraoperative histological examination as a serious problem for clinical application of sentinel node biopsy for early gastric cancer: final results of the Japan Clinical Oncology Group multicenter trial JCOG0302

Heterologous expression of high-activity cytochrome P450 in mammalian cells

Novel copy-number variations in pharmacogenes contribute to interindividual differences in drug pharmacokinetics

Development of a Simultaneous Liquid Chromatography-Tandem Mass Spectrometry Analytical Method for Urinary Endogenous Substrates and Metabolites for Predicting Cytochrome P450 3A4 Activity

Structural Impact Assessment of Cytochrome P450 2A13 Polymorphisms Using Molecular Dynamics Simulations

Hypoxia inhibits TNF-α-induced TSLP expression in keratinocytes

Variants of Flavin-Containing Monooxygenase 3 Found in Subjects in an Updated Database of Genome Resources

Hypoxia-inducible factor prolyl hydroxylase inhibitors suppressed thymic stromal lymphopoietin production and allergic responses in a mouse air-pouch-type ovalbumin sensitization model

jMorp: Japanese Multi-Omics Reference Panel update report 2023

Progress Report of the Tohoku Medical Megabank Community-based Cohort Study: Study Profile of the Repeated Center-based Survey During Second Period in Miyagi Prefecture

Structural investigation of pathogenic variants in dihydropyrimidinase using molecular dynamics simulations

Rare but impaired flavin-containing monooxygenase 3 (FMO3) variants reported in a recently updated Japanese mega-databank of genome resources

Lactate released from human fibroblasts enhances Ni elution from Ni plate

Validation of a genotyping technique for a surrogate marker of HLA-B58:01 for allopurinol-induced Stevens–Johnson syndrome and toxic epidermal necrolysis in the Japanese population

Genetic variants of flavin-containing monooxygenase 3 (FMO3) in Japanese subjects identified by phenotyping for trimethylaminuria and found in a database of genome resources

Functional Characterization of 21 Allelic Variants of Dihydropyrimidine Dehydrogenase Identified in 1070 Japanese Individuals

All- Trans Retinoic Acid Enhances Antibody Production by Inducing the Expression of Thymic Stromal Lymphopoietin Protein

Functional characterization of 50 CYP2D6 allelic variants by assessing primaquine 5-hydroxylation

Functional characterization of 17 CYP2D6 allelic variants (CYP2D6.2, 10, 14A-B, 18, 27, 36, 39, 47-51, 53-55, and 57)

Functional Characterization of 12 Dihydropyrimidinase Allelic Variants in Japanese Individuals for the Prediction of 5-Fluorouracil Treatment-Related Toxicity

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