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Mechanisms of acetaminophen-induced liver necrosis

Handbook of experimental pharmacology, 2010 (196), p.369

2010

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Acetaminophen-induced hepatotoxicity

Drug metabolism and disposition, 2003-12, Vol.31 (12), p.1499-1506

2003

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Resveratrol, a dietary polyphenolic phytoalexin, is a functional scavenger of peroxynitrite

Biochemical pharmacology, 2010-10, Vol.80 (8), p.1260-1265

2010

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Pharmacokinetics of acetaminophen-protein adducts in adults with acetaminophen overdose and acute liver failure

Drug metabolism and disposition, 2009-08, Vol.37 (8), p.1779-1784

2009

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Mechanisms of acetaminophen-induced hepatotoxicity: role of oxidative stress and mitochondrial permeability transition in freshly isolated mouse hepatocytes

The Journal of pharmacology and experimental therapeutics, 2005-02, Vol.312 (2), p.509-516

2005

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Acetaminophen-induced hepatotoxicity and protein nitration in neuronal nitric-oxide synthase knockout mice

The Journal of pharmacology and experimental therapeutics, 2012-01, Vol.340 (1), p.134-142

2012

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The development and hepatotoxicity of acetaminophen: reviewing over a century of progress

Drug metabolism reviews, 2020-10, Vol.52 (4), p.472-500

2020

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Acetaminophen-Induced Hepatotoxicity: Role of Metabolic Activation, Reactive Oxygen Nitrogen Species, and Mitochondrial Permeability Transition

Drug metabolism reviews, 2004, Vol.36 (3-4), p.805-822

2004

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Proinsulin atypical maturation and disposal induces extensive defects in mouse Ins2+/Akita β-cells

PloS one, 2012-04, Vol.7 (4), p.e35098

2012

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NADPH oxidase-derived oxidant stress is critical for neutrophil cytotoxicity during endotoxemia

American journal of physiology: Gastrointestinal and liver physiology, 2004-07, Vol.287 (1), p.G243-G252

2004

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Functional importance of ICAM-1 in the mechanism of neutrophil-induced liver injury in bile duct-ligated mice

American journal of physiology: Gastrointestinal and liver physiology, 2004-03, Vol.286 (3), p.G499-G507

2004

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Human recombinant vascular endothelial growth factor reduces necrosis and enhances hepatocyte regeneration in a mouse model of acetaminophen toxicity

The Journal of pharmacology and experimental therapeutics, 2010-07, Vol.334 (1), p.33-43

2010

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Trifluoperazine inhibits acetaminophen-induced hepatotoxicity and hepatic reactive nitrogen formation in mice and in freshly isolated hepatocytes

Toxicology reports, 2017-01, Vol.4, p.134-142

2017

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Acetaminophen Toxicity in Mice Lacking NADPH Oxidase Activity: Role of Peroxynitrite Formation and Mitochondrial Oxidant Stress

Free radical research, 2003-12, Vol.37 (12), p.1289-1297

2003

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In Vivo Mechanisms of Tissue-Selective Drug Toxicity: Effects of Liver-Specific Knockout of the NADPH-Cytochrome P450 Reductase Gene on Acetaminophen Toxicity in Kidney, Lung, and Nasal Mucosa

Molecular pharmacology, 2005-03, Vol.67 (3), p.623-630

2005

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Vascular endothelial growth factor and hepatocyte regeneration in acetaminophen toxicity

American journal of physiology: Gastrointestinal and liver physiology, 2006-07, Vol.291 (1), p.G102-G109

2006

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Determination of acetaminophen-protein adducts in mouse liver and serum and human serum after hepatotoxic doses of acetaminophen using high-performance liquid chromatography with electrochemical detection

Drug metabolism and disposition, 2002-04, Vol.30 (4), p.446-451

2002

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Nitrotyrosine−Protein Adducts in Hepatic Centrilobular Areas following Toxic Doses of Acetaminophen in Mice

Chemical research in toxicology, 1998-06, Vol.11 (6), p.604-607

1998

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Acetaminophen-induced hepatotoxicity in mice occurs with inhibition of activity and nitration of mitochondrial manganese superoxide dismutase

The Journal of pharmacology and experimental therapeutics, 2011-04, Vol.337 (1), p.110-118

2011

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An Immunoassay to Rapidly Measure Acetaminophen Protein Adducts Accurately Identifies Patients With Acute Liver Injury or Failure

Clinical gastroenterology and hepatology, 2017-04, Vol.15 (4), p.555-562.e3

2017

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Indocyanine green clearance varies as a function of N-acetylcysteine treatment in a murine model of acetaminophen toxicity

Chemico-biological interactions, 2011-02, Vol.189 (3), p.222-229

2011

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The neuronal nitric oxide synthase inhibitor NANT blocks acetaminophen toxicity and protein nitration in freshly isolated hepatocytes

Free radical biology & medicine, 2015-12, Vol.89, p.750-757

2015

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Cytokines and Toxicity in Acetaminophen Overdose

Journal of clinical pharmacology, 2005-10, Vol.45 (10), p.1165-1171

2005

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Mechanisms of hepatotoxicity

Toxicological sciences, 2002-02, Vol.65 (2), p.166-176

2002

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Effect of Inhibitors of Nitric Oxide Synthase on Acetaminophen-Induced Hepatotoxicity in Mice

Nitric oxide, 2002-03, Vol.6 (2), p.160-167

2002

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Mechanisms of acetaminophen-induced liver necrosis

Acetaminophen-induced hepatotoxicity

Resveratrol, a dietary polyphenolic phytoalexin, is a functional scavenger of peroxynitrite

Pharmacokinetics of acetaminophen-protein adducts in adults with acetaminophen overdose and acute liver failure

Mechanisms of acetaminophen-induced hepatotoxicity: role of oxidative stress and mitochondrial permeability transition in freshly isolated mouse hepatocytes

Acetaminophen-induced hepatotoxicity and protein nitration in neuronal nitric-oxide synthase knockout mice

The development and hepatotoxicity of acetaminophen: reviewing over a century of progress

Acetaminophen-Induced Hepatotoxicity: Role of Metabolic Activation, Reactive Oxygen Nitrogen Species, and Mitochondrial Permeability Transition

Proinsulin atypical maturation and disposal induces extensive defects in mouse Ins2+/Akita β-cells

NADPH oxidase-derived oxidant stress is critical for neutrophil cytotoxicity during endotoxemia

Functional importance of ICAM-1 in the mechanism of neutrophil-induced liver injury in bile duct-ligated mice

Human recombinant vascular endothelial growth factor reduces necrosis and enhances hepatocyte regeneration in a mouse model of acetaminophen toxicity

Trifluoperazine inhibits acetaminophen-induced hepatotoxicity and hepatic reactive nitrogen formation in mice and in freshly isolated hepatocytes

Acetaminophen Toxicity in Mice Lacking NADPH Oxidase Activity: Role of Peroxynitrite Formation and Mitochondrial Oxidant Stress

In Vivo Mechanisms of Tissue-Selective Drug Toxicity: Effects of Liver-Specific Knockout of the NADPH-Cytochrome P450 Reductase Gene on Acetaminophen Toxicity in Kidney, Lung, and Nasal Mucosa

Vascular endothelial growth factor and hepatocyte regeneration in acetaminophen toxicity

Determination of acetaminophen-protein adducts in mouse liver and serum and human serum after hepatotoxic doses of acetaminophen using high-performance liquid chromatography with electrochemical detection

Nitrotyrosine−Protein Adducts in Hepatic Centrilobular Areas following Toxic Doses of Acetaminophen in Mice

Acetaminophen-induced hepatotoxicity in mice occurs with inhibition of activity and nitration of mitochondrial manganese superoxide dismutase

An Immunoassay to Rapidly Measure Acetaminophen Protein Adducts Accurately Identifies Patients With Acute Liver Injury or Failure

Indocyanine green clearance varies as a function of N-acetylcysteine treatment in a murine model of acetaminophen toxicity

The neuronal nitric oxide synthase inhibitor NANT blocks acetaminophen toxicity and protein nitration in freshly isolated hepatocytes

Cytokines and Toxicity in Acetaminophen Overdose

Mechanisms of hepatotoxicity

Effect of Inhibitors of Nitric Oxide Synthase on Acetaminophen-Induced Hepatotoxicity in Mice

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