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Anti-angiogenic, vascular-disrupting and anti-metastatic activities of vinflunine, the latest vinca alkaloid in clinical development

European journal of cancer (1990), 2006-11, Vol.42 (16), p.2821-2832

2006

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Decreased Nucleotide Excision Repair Activity and Alterations of Topoisomerase IIα Are Associated with the in Vivo Resistance of a P388 Leukemia Subline to F11782, a Novel Catalytic Inhibitor of Topoisomerases I and II

Clinical cancer research, 2004-05, Vol.10 (9), p.3156-3168

2004

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Vinflunine, the latest Vinca alkaloid in clinical development : A review of its preclinical anticancer properties

Critical reviews in oncology/hematology, 2001-11, Vol.40 (2), p.159-173

2001

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The effects of vinflunine, vinorelbine, and vinblastine on centromere dynamics

Molecular cancer therapeutics, 2003-05, Vol.2 (5), p.427-436

2003

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Mechanism of Mitotic Block and Inhibition of Cell Proliferation by the Semisynthetic Vinca Alkaloids Vinorelbine and Its Newer Derivative Vinflunine

Molecular pharmacology, 2001-07, Vol.60 (1), p.225-232

2001

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Apoptotic cell death induction by F 11782 a novel dual catalytic inhibitor of topoisomerases I and II

Biochemical pharmacology, 2003-03, Vol.65 (5), p.755-763

2003

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Vinflunine, a second generation novel Vinca Alkaloid with a distinctive pharmacological profile, now in clinical development and prospects for future mitotic blockers

Current pharmaceutical design, 2001-09, Vol.7 (13), p.1199-1212

Hill, B T

2001

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Synthesis of 9-acridinyl sulfur derivatives: sulfides, sulfoxides and sulfones. Comparison of their activity on tumour cells

European journal of medicinal chemistry, 2004-12, Vol.39 (12), p.1029-1038

2004

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Cisplatin resistance and oncogenes - a review

Anti-cancer drugs, 2000-04, Vol.11 (4), p.225-236

2000

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Classic in vivo cancer models: three examples of mouse models used in experimental therapeutics

Current Protocols in Pharmacology, 2002-02, Vol.Chapter 5 (1), p.Unit5.24-Unit5.24

2002

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F 11782, a novel epipodophylloid non-intercalating dual catalytic inhibitor of topoisomerases I and II with an original mechanism of action

Biochemical pharmacology, 2000-04, Vol.59 (7), p.807-819

2000

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Inhibition of nucleotide excision repair and sensitisation of cells to DNA cross-linking anticancer drugs by F 11782, a novel fluorinated epipodophylloid

Biochemical pharmacology, 2002-01, Vol.63 (2), p.251-258

2002

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Preclinical in vivo antitumor activity of vinflunine, a novel fluorinated Vinca alkaloid

Cancer chemotherapy and pharmacology, 1998, Vol.41 (6), p.437-447

1998

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Inhibition of RAS-targeted prenylation: protein farnesyl transferase inhibitors revisited

Critical reviews in oncology/hematology, 2000, Vol.33 (1), p.7-23

2000

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A Comparison of Thermodynamic Parameters for Vinorelbine- and Vinflunine-Induced Tubulin Self-Association by Sedimentation Velocity

Molecular pharmacology, 1998-05, Vol.53 (5), p.908

1998

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Vinca Alkaloid-Induced Tubulin Spiral Formation Correlates with Cytotoxicity in the Leukemic L1210 Cell Line

Biochemistry (Easton), 2000-10, Vol.39 (39), p.12053-12062

2000

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Ex vivo effects of the dual topoisomerase inhibitor tafluposide (F 11782) on cells isolated from fresh tumor samples taken from patients with cancer

Anti-cancer drugs, 2003-07, Vol.14 (6), p.467-473

2003

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A dual mechanism of action of the anticancer agent F 11782 on human topoisomerase II α

Biochemical pharmacology, 2003-08, Vol.66 (4), p.623-631

2003

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Synergistic effects of F 11782, a novel dual inhibitor of topoisomerases I and II, in combination with other anticancer agents

Cancer chemotherapy and pharmacology, 2002-06, Vol.49 (6), p.479-486

2002

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Heteronemin as a protein farnesyl transferase inhibitor

Pharmaceutical biology, 2004-01, Vol.42 (6), p.454-456

2004

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F 11782, a novel catalytic inhibitor of topoisomerases I and II, induces atypical, yet cytotoxic DNA double-strand breaks in CHO-K1 cells

Anticancer research, 2002-01, Vol.22 (1A), p.187

2002

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Vinflunine (20', 20'-difluoro-3', 4'-dihydrovinorelbine), a novel Vinca alkaloid, which participates in P-glycoprotein (Pgp)-mediated multidrug resistance in vivo and in vitro

Investigational new drugs, 1998-01, Vol.16 (1), p.3-17

1998

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Differential sensitivities of recombinant human topoisomerase IIα and β to various classes of topoisomerase II-interacting agents

Biochemical pharmacology, 1998-08, Vol.56 (4), p.503-507

1998

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Synthesis and Antitumor Activity of New Glycosides of Epipodophyllotoxin, Analogues of Etoposide, and NK 611

Journal of medicinal chemistry, 1998-11, Vol.41 (23), p.4475-4485

1998

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Vinflunine, a new vinca alkaloid: cytotoxicity, cellular accumulation and action on the interphasic and mitotic microtubule cytoskeleton of PtK2 cells

Anti-cancer drugs, 1999-07, Vol.10 (6), p.537-544

1999

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Anti-angiogenic, vascular-disrupting and anti-metastatic activities of vinflunine, the latest vinca alkaloid in clinical development

Decreased Nucleotide Excision Repair Activity and Alterations of Topoisomerase IIα Are Associated with the in Vivo Resistance of a P388 Leukemia Subline to F11782, a Novel Catalytic Inhibitor of Topoisomerases I and II

Vinflunine, the latest Vinca alkaloid in clinical development : A review of its preclinical anticancer properties

The effects of vinflunine, vinorelbine, and vinblastine on centromere dynamics

Mechanism of Mitotic Block and Inhibition of Cell Proliferation by the Semisynthetic Vinca Alkaloids Vinorelbine and Its Newer Derivative Vinflunine

Apoptotic cell death induction by F 11782 a novel dual catalytic inhibitor of topoisomerases I and II

Vinflunine, a second generation novel Vinca Alkaloid with a distinctive pharmacological profile, now in clinical development and prospects for future mitotic blockers

Synthesis of 9-acridinyl sulfur derivatives: sulfides, sulfoxides and sulfones. Comparison of their activity on tumour cells

Cisplatin resistance and oncogenes - a review

Classic in vivo cancer models: three examples of mouse models used in experimental therapeutics

F 11782, a novel epipodophylloid non-intercalating dual catalytic inhibitor of topoisomerases I and II with an original mechanism of action

Inhibition of nucleotide excision repair and sensitisation of cells to DNA cross-linking anticancer drugs by F 11782, a novel fluorinated epipodophylloid

Preclinical in vivo antitumor activity of vinflunine, a novel fluorinated Vinca alkaloid

Inhibition of RAS-targeted prenylation: protein farnesyl transferase inhibitors revisited

A Comparison of Thermodynamic Parameters for Vinorelbine- and Vinflunine-Induced Tubulin Self-Association by Sedimentation Velocity

Vinca Alkaloid-Induced Tubulin Spiral Formation Correlates with Cytotoxicity in the Leukemic L1210 Cell Line

Ex vivo effects of the dual topoisomerase inhibitor tafluposide (F 11782) on cells isolated from fresh tumor samples taken from patients with cancer

A dual mechanism of action of the anticancer agent F 11782 on human topoisomerase II α

Synergistic effects of F 11782, a novel dual inhibitor of topoisomerases I and II, in combination with other anticancer agents

Heteronemin as a protein farnesyl transferase inhibitor

F 11782, a novel catalytic inhibitor of topoisomerases I and II, induces atypical, yet cytotoxic DNA double-strand breaks in CHO-K1 cells

Vinflunine (20', 20'-difluoro-3', 4'-dihydrovinorelbine), a novel Vinca alkaloid, which participates in P-glycoprotein (Pgp)-mediated multidrug resistance in vivo and in vitro

Differential sensitivities of recombinant human topoisomerase IIα and β to various classes of topoisomerase II-interacting agents

Synthesis and Antitumor Activity of New Glycosides of Epipodophyllotoxin, Analogues of Etoposide, and NK 611

Vinflunine, a new vinca alkaloid: cytotoxicity, cellular accumulation and action on the interphasic and mitotic microtubule cytoskeleton of PtK2 cells

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