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Discovery of a Novel Class of Dimeric Smac Mimetics as Potent IAP Antagonists Resulting in a Clinical Candidate for the Treatment of Cancer (AZD5582)

Journal of medicinal chemistry, 2013-12, Vol.56 (24), p.9897-9919

2013

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Selective inhibitors of Bcl-2 and Bcl-xL: Balancing antitumor activity with on-target toxicity

Bioorganic & medicinal chemistry letters, 2016-05, Vol.26 (9), p.2105-2114

Hennessy, Edward J.

2016

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Discovery of Potent KIFC1 Inhibitors Using a Method of Integrated High-Throughput Synthesis and Screening

Journal of medicinal chemistry, 2014-12, Vol.57 (23), p.9958-9970

2014

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A General and Mild Copper-Catalyzed Arylation of Diethyl Malonate

Organic letters, 2002-01, Vol.4 (2), p.269-272

2002

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Synthesis of Substituted Oxindoles from α-Chloroacetanilides via Palladium-Catalyzed C−H Functionalization

Journal of the American Chemical Society, 2003-10, Vol.125 (40), p.12084-12085

2003

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Discovery of aminopiperidine-based Smac mimetics as IAP antagonists

Bioorganic & medicinal chemistry letters, 2012-02, Vol.22 (4), p.1690-1694

2012

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Direct and selective elimination of specific prions and amyloids by 4,5-dianilinophthalimide and analogs

Proceedings of the National Academy of Sciences - PNAS, 2008-05, Vol.105 (20), p.7159-7164

2008

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Structure-based design and synthesis of tricyclic IAP (Inhibitors of Apoptosis Proteins) inhibitors

Bioorganic & medicinal chemistry letters, 2014-04, Vol.24 (7), p.1820-1824

2014

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Discovery and Optimization of the First ATP Competitive Type-III c‑MET Inhibitor

Journal of medicinal chemistry, 2023-07, Vol.66 (13), p.8782-8807

2023

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Optimization of an Imidazo[1,2‑a]pyridine Series to Afford Highly Selective Type I1/2 Dual Mer/Axl Kinase Inhibitors with In Vivo Efficacy

Journal of medicinal chemistry, 2021-09, Vol.64 (18), p.13524-13539

2021

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Generating Selective Leads for Mer Kinase InhibitorsExample of a Comprehensive Lead-Generation Strategy

Journal of medicinal chemistry, 2021-03, Vol.64 (6), p.3165-3184

2021

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Structural and Molecular Insight into Resistance Mechanisms of First Generation cMET Inhibitors

ACS medicinal chemistry letters, 2019-09, Vol.10 (9), p.1322-1327

2019

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Identification and Optimization of Benzimidazole Sulfonamides as Orally Bioavailable Sphingosine 1‑Phosphate Receptor 1 Antagonists with in Vivo Activity

Journal of medicinal chemistry, 2015-09, Vol.58 (17), p.7057-7075

2015

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Preparation of highly functionalized 1,5-disubstituted tetrazoles via palladium-catalyzed Suzuki coupling

Tetrahedron letters, 2017-04, Vol.58 (17), p.1709-1713

2017

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Small molecule inhibitor of apoptosis proteins antagonists: a patent review

Expert opinion on therapeutic patents, 2015-07, Vol.25 (7), p.755-774

2015

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Optimization of Highly Kinase Selective Bis-anilino Pyrimidine PAK1 Inhibitors

ACS medicinal chemistry letters, 2016-12, Vol.7 (12), p.1118-1123

2016

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Discovery of heterocyclic sulfonamides as sphingosine 1-phosphate receptor 1 (S1P1) antagonists

Bioorganic & medicinal chemistry letters, 2015-05, Vol.25 (10), p.2041-2045

2015

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Utilization of Structure-Based Design to Identify Novel, Irreversible Inhibitors of EGFR Harboring the T790M Mutation

ACS medicinal chemistry letters, 2016-05, Vol.7 (5), p.514-519

2016

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Selective inhibitors of Bcl-2 and Bcl-x sub(L): Balancing antitumor activity with on-target toxicity

Bioorganic & medicinal chemistry letters, 2016-05, Vol.26 (9), p.2105-2114

Hennessy, Edward J

2016

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Synthesis of 4,5-Dianilinophthalimide and Related Analogues for Potential Treatment of Alzheimer's Disease via Palladium-Catalyzed Amination

Journal of organic chemistry, 2005-09, Vol.70 (18), p.7371-7375

2005

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trans-Cyclopropyl β-Amino Acid Derivatives via Asymmetric Cyclopropanation Using a (Salen)Ru(II) Catalyst

Journal of organic chemistry, 2003-10, Vol.68 (20), p.7884-7886

2003

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AZD4320, A Dual Inhibitor of Bcl-2 and Bcl-xL, Induces Tumor Regression in Hematologic Cancer Models without Dose-limiting Thrombocytopenia

Clinical cancer research, 2020-12, Vol.26 (24), p.6535-6549

2020

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Abstract 311: AZD4320 is a potent, dual Bcl-2/xLinhibitor that rapidly induces apoptosis in preclinical hematologic tumor models

Cancer research (Chicago, Ill.), 2018-07, Vol.78 (13_Supplement), p.311-311

2018

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ChemInform Abstract: Selective Inhibitors of Bcl‐2 and Bcl‐xL: Balancing Antitumor Activity with On‐Target Toxicity

ChemInform, 2016-05, Vol.47 (23), p.no-no

Hennessy, Edward J.

2016

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Design and optimisation of dendrimer-conjugated Bcl-2/xL inhibitor, AZD0466, with improved therapeutic index for cancer therapy

Communications biology, 2021-01, Vol.4 (1), p.1-14, Article 112

2021

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Discovery of a Novel Class of Dimeric Smac Mimetics as Potent IAP Antagonists Resulting in a Clinical Candidate for the Treatment of Cancer (AZD5582)

Selective inhibitors of Bcl-2 and Bcl-xL: Balancing antitumor activity with on-target toxicity

Discovery of Potent KIFC1 Inhibitors Using a Method of Integrated High-Throughput Synthesis and Screening

A General and Mild Copper-Catalyzed Arylation of Diethyl Malonate

Synthesis of Substituted Oxindoles from α-Chloroacetanilides via Palladium-Catalyzed C−H Functionalization

Discovery of aminopiperidine-based Smac mimetics as IAP antagonists

Direct and selective elimination of specific prions and amyloids by 4,5-dianilinophthalimide and analogs

Structure-based design and synthesis of tricyclic IAP (Inhibitors of Apoptosis Proteins) inhibitors

Discovery and Optimization of the First ATP Competitive Type-III c‑MET Inhibitor

Optimization of an Imidazo[1,2‑a]pyridine Series to Afford Highly Selective Type I1/2 Dual Mer/Axl Kinase Inhibitors with In Vivo Efficacy

Generating Selective Leads for Mer Kinase InhibitorsExample of a Comprehensive Lead-Generation Strategy

Structural and Molecular Insight into Resistance Mechanisms of First Generation cMET Inhibitors

Identification and Optimization of Benzimidazole Sulfonamides as Orally Bioavailable Sphingosine 1‑Phosphate Receptor 1 Antagonists with in Vivo Activity

Preparation of highly functionalized 1,5-disubstituted tetrazoles via palladium-catalyzed Suzuki coupling

Small molecule inhibitor of apoptosis proteins antagonists: a patent review

Optimization of Highly Kinase Selective Bis-anilino Pyrimidine PAK1 Inhibitors

Discovery of heterocyclic sulfonamides as sphingosine 1-phosphate receptor 1 (S1P1) antagonists

Utilization of Structure-Based Design to Identify Novel, Irreversible Inhibitors of EGFR Harboring the T790M Mutation

Selective inhibitors of Bcl-2 and Bcl-x sub(L): Balancing antitumor activity with on-target toxicity

Synthesis of 4,5-Dianilinophthalimide and Related Analogues for Potential Treatment of Alzheimer's Disease via Palladium-Catalyzed Amination

trans-Cyclopropyl β-Amino Acid Derivatives via Asymmetric Cyclopropanation Using a (Salen)Ru(II) Catalyst

AZD4320, A Dual Inhibitor of Bcl-2 and Bcl-xL, Induces Tumor Regression in Hematologic Cancer Models without Dose-limiting Thrombocytopenia

Abstract 311: AZD4320 is a potent, dual Bcl-2/xLinhibitor that rapidly induces apoptosis in preclinical hematologic tumor models

ChemInform Abstract: Selective Inhibitors of Bcl‐2 and Bcl‐xL: Balancing Antitumor Activity with On‐Target Toxicity

Design and optimisation of dendrimer-conjugated Bcl-2/xL inhibitor, AZD0466, with improved therapeutic index for cancer therapy

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