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The PPARs: From Orphan Receptors to Drug Discovery

Journal of medicinal chemistry, 2000-02, Vol.43 (4), p.527-550

2000

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A novel N-aryl tyrosine activator of peroxisome proliferator-activated receptor-gamma reverses the diabetic phenotype of the Zucker diabetic fatty rat

Diabetes (New York, N.Y.), 1999-07, Vol.48 (7), p.1415

1999

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PPAR modulators and PPAR pan agonists for metabolic diseases: the next generation of drugs targeting peroxisome proliferator-activated receptors?

Current topics in medicinal chemistry, 2008-06, Vol.8 (9), p.728

2008

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A New Series of Estrogen Receptor Modulators That Display Selectivity for Estrogen Receptor β

Journal of medicinal chemistry, 2002-12, Vol.45 (25), p.5492-5505

2002

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Optimization of 3-(1H-Indazol-3-ylmethyl)-1,5-benzodiazepines as Potent, Orally Active CCK-A Agonists

Journal of medicinal chemistry, 1997-08, Vol.40 (17), p.2706-2725

1997

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Peroxisome Proliferator-Activated Receptor α/γ Dual Agonists for the Treatment of Type 2 Diabetes

Journal of medicinal chemistry, 2004-08, Vol.47 (17), p.4118-4127

Henke, Brad R

2004

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3-[2-(N-Phenylacetamide)]-1,5-benzodiazepines: Orally Active, Binding Selective CCK-A Agonists

Journal of medicinal chemistry, 1996-07, Vol.39 (15), p.3030-3034

1996

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3-[4-(1,2-Diphenylbut-1-enyl)phenyl]acrylic Acid: A Non-Steroidal Estrogen with Functional Selectivity for Bone over Uterus in Rats

Journal of medicinal chemistry, 1994-05, Vol.37 (11), p.1550-1552

1994

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2-Amino-4,6-diarylpyridines as novel ligands for the estrogen receptor

Bioorganic & medicinal chemistry letters, 2001-07, Vol.11 (14), p.1939-1942

2001

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Intramolecular 1,3-dipolar cycloaddition of stabilized azomethine ylides to unactivated dipolarophiles

Journal of organic chemistry, 1992-12, Vol.57 (26), p.7056-7066

1992

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Investigations on transition-state geometry in the aldol condensation

Journal of the American Chemical Society, 1991-03, Vol.113 (6), p.2177-2194

1991

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Synthesis and biological activity of a novel series of indole-derived PPARγ agonists

Bioorganic & medicinal chemistry letters, 1999-12, Vol.9 (23), p.3329-3334

1999

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3-(1H-indazol-3-ylmethyl)-1,5-benzo-diazepines : CCK-A agonists that demonstrate oral activity as satiety agents

Journal of medicinal chemistry, 1996, Vol.39 (14), p.2655-2658

1996

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SnCl4(4-tert-BuC6H4CHO)2. X-ray crystal structure, solution NMR, and implications for reactions at complexed carbonyls

Journal of the American Chemical Society, 1987-04, Vol.109 (8), p.2512-2514

1987

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3-(1H-Indazol-3-ylmethyl)-1,5-benzodiazepines: CCK-A Agonists That Demonstrate Oral Activity as Satiety Agents

Journal of medicinal chemistry, 1996-07, Vol.39 (14), p.2655-2658

1996

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Identification of a series of oxadiazole-substituted alpha-isopropoxy phenylpropanoic acids with activity on PPARalpha, PPARgamma, and PPARdelta

Bioorganic & medicinal chemistry letters, 2001-09, Vol.11 (17), p.2385-2388

2001

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Investigations on transition-state geometry in the aldol condensation

Journal of the American Chemical Society, 1989-09, Vol.111 (20), p.8032-8034

1989

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N-(2-Benzoylphenyl)-l-tyrosine PPARγ Agonists. 3. Structure−Activity Relationship and Optimization of the N-Aryl Substituent

Journal of medicinal chemistry, 1998-12, Vol.41 (25), p.5055-5069

1998

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N-(2-Benzoylphenyl)-l-tyrosine PPARγ Agonists. 2. Structure−Activity Relationship and Optimization of the Phenyl Alkyl Ether Moiety

Journal of medicinal chemistry, 1998-12, Vol.41 (25), p.5037-5054

1998

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Synthesis and biological activity of l-tyrosine-based PPARγ agonists with reduced molecular weight

Bioorganic & medicinal chemistry letters, 2001-12, Vol.11 (24), p.3111-3113

2001

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Synthesis and biological activity of L-tyrosine-based PPARgamma agonists with reduced molecular weight

Bioorganic & medicinal chemistry letters, 2001-12, Vol.11 (24), p.3111-3113

2001

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Synthesis and biological activity of a novel series of indole-derived PPARgamma agonists

Bioorganic & medicinal chemistry letters, 1999-12, Vol.9 (23), p.3329-3334

1999

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N-(2-Benzoylphenyl)-L-tyrosine PPARgamma agonists. 3. Structure-activity relationship and optimization of the N-aryl substituent

Journal of medicinal chemistry, 1998-12, Vol.41 (25), p.5055-5069

1998

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N-(2-Benzoylphenyl)-L-tyrosine PPARgamma agonists. 2. Structure-activity relationship and optimization of the phenyl alkyl ether moiety

Journal of medicinal chemistry, 1998-12, Vol.41 (25), p.5037-5054

1998

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N-(2-Benzoylphenyl)-L-tyrosine PPARgamma agonists. 1. Discovery of a novel series of potent antihyperglycemic and antihyperlipidemic agents

Journal of medicinal chemistry, 1998-12, Vol.41 (25), p.5020-5036

1998

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The PPARs: From Orphan Receptors to Drug Discovery

A novel N-aryl tyrosine activator of peroxisome proliferator-activated receptor-gamma reverses the diabetic phenotype of the Zucker diabetic fatty rat

PPAR modulators and PPAR pan agonists for metabolic diseases: the next generation of drugs targeting peroxisome proliferator-activated receptors?

A New Series of Estrogen Receptor Modulators That Display Selectivity for Estrogen Receptor β

Optimization of 3-(1H-Indazol-3-ylmethyl)-1,5-benzodiazepines as Potent, Orally Active CCK-A Agonists

Peroxisome Proliferator-Activated Receptor α/γ Dual Agonists for the Treatment of Type 2 Diabetes

3-[2-(N-Phenylacetamide)]-1,5-benzodiazepines: Orally Active, Binding Selective CCK-A Agonists

3-[4-(1,2-Diphenylbut-1-enyl)phenyl]acrylic Acid: A Non-Steroidal Estrogen with Functional Selectivity for Bone over Uterus in Rats

2-Amino-4,6-diarylpyridines as novel ligands for the estrogen receptor

Intramolecular 1,3-dipolar cycloaddition of stabilized azomethine ylides to unactivated dipolarophiles

Investigations on transition-state geometry in the aldol condensation

Synthesis and biological activity of a novel series of indole-derived PPARγ agonists

3-(1H-indazol-3-ylmethyl)-1,5-benzo-diazepines : CCK-A agonists that demonstrate oral activity as satiety agents

SnCl4(4-tert-BuC6H4CHO)2. X-ray crystal structure, solution NMR, and implications for reactions at complexed carbonyls

3-(1H-Indazol-3-ylmethyl)-1,5-benzodiazepines: CCK-A Agonists That Demonstrate Oral Activity as Satiety Agents

Identification of a series of oxadiazole-substituted alpha-isopropoxy phenylpropanoic acids with activity on PPARalpha, PPARgamma, and PPARdelta

Investigations on transition-state geometry in the aldol condensation

N-(2-Benzoylphenyl)-l-tyrosine PPARγ Agonists. 3. Structure−Activity Relationship and Optimization of the N-Aryl Substituent

N-(2-Benzoylphenyl)-l-tyrosine PPARγ Agonists. 2. Structure−Activity Relationship and Optimization of the Phenyl Alkyl Ether Moiety

Synthesis and biological activity of l-tyrosine-based PPARγ agonists with reduced molecular weight

Synthesis and biological activity of L-tyrosine-based PPARgamma agonists with reduced molecular weight

Synthesis and biological activity of a novel series of indole-derived PPARgamma agonists

N-(2-Benzoylphenyl)-L-tyrosine PPARgamma agonists. 3. Structure-activity relationship and optimization of the N-aryl substituent

N-(2-Benzoylphenyl)-L-tyrosine PPARgamma agonists. 2. Structure-activity relationship and optimization of the phenyl alkyl ether moiety

N-(2-Benzoylphenyl)-L-tyrosine PPARgamma agonists. 1. Discovery of a novel series of potent antihyperglycemic and antihyperlipidemic agents

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