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Dissolution behavior of co-amorphous amino acid-indomethacin mixtures: The ability of amino acids to stabilize the supersaturated state of indomethacin

European journal of pharmaceutics and biopharmaceutics, 2017-03, Vol.112, p.85-95

2017

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Analysis of Unstirred Water Layer in In Vitro Permeability Experiments

Journal of pharmaceutical sciences, 2009-12, Vol.98 (12), p.4469-4479

2009

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Application of PBPK modeling to predict human intestinal metabolism of CYP3A substrates – An evaluation and case study using GastroPlus

European journal of pharmaceutical sciences, 2012-09, Vol.47 (2), p.375-386

2012

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In vitro methods to study the interplay of drug metabolism and efflux in the intestine

Current drug metabolism, 2013-01, Vol.14 (1), p.102-111

2013

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Quantitative ADME Proteomics – CYP and UGT Enzymes in the Beagle Dog Liver and Intestine

Pharmaceutical research, 2015-01, Vol.32 (1), p.74-90

2015

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In vitro glucuronidation of 7-hydroxycoumarin derivatives in intestine and liver microsomes of Beagle dogs

European journal of pharmaceutical sciences, 2020-01, Vol.141, p.105118, Article 105118

2020

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The role of quantitative ADME proteomics to support construction of physiologically based pharmacokinetic models for use in small molecule drug development

Proteomics. Clinical applications, 2015-08, Vol.9 (7-8), p.732-744

2015

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PBPK Modeling as a Tool for Predicting and Understanding Intestinal Metabolism of Uridine 5′-Diphospho-glucuronosyltransferase Substrates

Pharmaceutics, 2021-08, Vol.13 (9), p.1325

2021

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Physiologically Based Pharmacokinetic Modelling for First-In-Human Predictions: An Updated Model Building Strategy Illustrated with Challenging Industry Case Studies

Clinical pharmacokinetics, 2019-06, Vol.58 (6), p.727-746

2019

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Mass Spectrometry-Based Quantification of CYP Enzymes to Establish In Vitro/In Vivo Scaling Factors for Intestinal and Hepatic Metabolism in Beagle Dog

Pharmaceutical research, 2012-07, Vol.29 (7), p.1832-1842

2012

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In vitro–in vivo correlation in p-glycoprotein mediated transport in intestinal absorption

European journal of pharmaceutical sciences, 2009-02, Vol.36 (2-3), p.200-211

2009

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The Asymmetry of the Unstirred Water Layer in Permeability Experiments

Pharmaceutical research, 2008-07, Vol.25 (7), p.1714-1722

2008

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Kinetics of cellular retention during Caco-2 permeation experiments: role of lysosomal sequestration and impact on permeability estimates

The Journal of pharmacology and experimental therapeutics, 2009-03, Vol.328 (3), p.882-892

2009

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Decrease in intracellular concentration causes the shift in Km value of efflux pump substrates

Drug metabolism and disposition, 2007-09, Vol.35 (9), p.1574

2007

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Effects of Experimental Setup on the Apparent Concentration Dependency of Active Efflux Transport in in Vitro Cell Permeation Experiments

Molecular pharmaceutics, 2010-04, Vol.7 (2), p.605-617

2010

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Applications of a 7-day Caco-2 cell model in drug discovery and development

European journal of pharmaceutical sciences, 2014-06, Vol.56, p.120-130

2014

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Analysis of the bile acid composition in a fibroblast growth factor 19-expressing liver-humanized mouse model and its use for CYP3A4-mediated drug-drug interaction studies

Drug metabolism and disposition, 2023-10, Vol.51 (10), p.1391-1402

2023

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Metabolism of Scoparone in Experimental Animals and Humans

Planta medica, 2019-04, Vol.85 (6), p.453-464

2019

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Intracellular PK/PD Relationships of Free and Liposomal Doxorubicin: Quantitative Analyses and PK/PD Modeling

Molecular pharmaceutics, 2016-04, Vol.13 (4), p.1358-1365

2016

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Physiologically based pharmacokinetic modelling of oxycodone drug–drug interactions

Biopharmaceutics & drug disposition, 2020-02, Vol.41 (1-2), p.72-88

2020

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In Vitro to in Vivo Extrapolation and Physiologically Based Modeling of Cytochrome P450 Mediated Metabolism in Beagle Dog Gut Wall and Liver

Molecular pharmaceutics, 2013-04, Vol.10 (4), p.1388-1399

2013

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Fentanyl Pharmacokinetics in Pregnant Sheep after Intravenous and Transdermal Administration to the Ewe

Basic & clinical pharmacology & toxicology, 2015-09, Vol.117 (3), p.156-163

2015

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Modelling of Drug Disposition Kinetics in In Vitro Intestinal Absorption Cell Models

Basic & clinical pharmacology & toxicology, 2010-03, Vol.106 (3), p.180-188

2010

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Determination of permeation resistance distribution in in vitro cell monolayer permeation experiments

European journal of pharmaceutical sciences, 2010-05, Vol.40 (2), p.132-142

2010

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Protein concentration and pH affect the apparent P-glycoprotein–ATPase activation kinetics

International journal of pharmaceutics, 2008-01, Vol.346 (1), p.169-172

2008

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Dissolution behavior of co-amorphous amino acid-indomethacin mixtures: The ability of amino acids to stabilize the supersaturated state of indomethacin

Analysis of Unstirred Water Layer in In Vitro Permeability Experiments

Application of PBPK modeling to predict human intestinal metabolism of CYP3A substrates – An evaluation and case study using GastroPlus

In vitro methods to study the interplay of drug metabolism and efflux in the intestine

Quantitative ADME Proteomics – CYP and UGT Enzymes in the Beagle Dog Liver and Intestine

In vitro glucuronidation of 7-hydroxycoumarin derivatives in intestine and liver microsomes of Beagle dogs

The role of quantitative ADME proteomics to support construction of physiologically based pharmacokinetic models for use in small molecule drug development

PBPK Modeling as a Tool for Predicting and Understanding Intestinal Metabolism of Uridine 5′-Diphospho-glucuronosyltransferase Substrates

Physiologically Based Pharmacokinetic Modelling for First-In-Human Predictions: An Updated Model Building Strategy Illustrated with Challenging Industry Case Studies

Mass Spectrometry-Based Quantification of CYP Enzymes to Establish In Vitro/In Vivo Scaling Factors for Intestinal and Hepatic Metabolism in Beagle Dog

In vitro–in vivo correlation in p-glycoprotein mediated transport in intestinal absorption

The Asymmetry of the Unstirred Water Layer in Permeability Experiments

Kinetics of cellular retention during Caco-2 permeation experiments: role of lysosomal sequestration and impact on permeability estimates

Decrease in intracellular concentration causes the shift in Km value of efflux pump substrates

Effects of Experimental Setup on the Apparent Concentration Dependency of Active Efflux Transport in in Vitro Cell Permeation Experiments

Applications of a 7-day Caco-2 cell model in drug discovery and development

Analysis of the bile acid composition in a fibroblast growth factor 19-expressing liver-humanized mouse model and its use for CYP3A4-mediated drug-drug interaction studies

Metabolism of Scoparone in Experimental Animals and Humans

Intracellular PK/PD Relationships of Free and Liposomal Doxorubicin: Quantitative Analyses and PK/PD Modeling

Physiologically based pharmacokinetic modelling of oxycodone drug–drug interactions

In Vitro to in Vivo Extrapolation and Physiologically Based Modeling of Cytochrome P450 Mediated Metabolism in Beagle Dog Gut Wall and Liver

Fentanyl Pharmacokinetics in Pregnant Sheep after Intravenous and Transdermal Administration to the Ewe

Modelling of Drug Disposition Kinetics in In Vitro Intestinal Absorption Cell Models

Determination of permeation resistance distribution in in vitro cell monolayer permeation experiments

Protein concentration and pH affect the apparent P-glycoprotein–ATPase activation kinetics

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