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Discovery of CRBN E3 Ligase Modulator CC-92480 for the Treatment of Relapsed and Refractory Multiple Myeloma

Journal of medicinal chemistry, 2020-07, Vol.63 (13), p.6648-6676

2020

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A Genome-wide Screen Identifies p97 as an Essential Regulator of DNA Damage-Dependent CDT1 Destruction

Molecular cell, 2011-10, Vol.44 (1), p.72-84

2011

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Mechanism of CRL4(Cdt2), a PCNA-dependent E3 ubiquitin ligase

Genes & development, 2011-08, Vol.25 (15), p.1568-1582

2011

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Ribonucleotide Reductase Activity Is Coupled to DNA Synthesis via Proliferating Cell Nuclear Antigen

Current biology, 2012-04, Vol.22 (8), p.720-726

2012

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Immunomodulatory agents lenalidomide and pomalidomide co-stimulate T cells by inducing degradation of T cell repressors Ikaros and Aiolos via modulation of the E3 ubiquitin ligase complex CRL4(CRBN.)

British journal of haematology, 2014-03, Vol.164 (6), p.811

2014

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Mechanism of CRL4Cdt2, a PCNA-dependent E3 ubiquitin ligase

Genes & development, 2011-08, Vol.25 (15), p.1568-1582

2011

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CRL4(Cdt2)-mediated destruction of the histone methyltransferase Set8 prevents premature chromatin compaction in S phase

Molecular cell, 2010-10, Vol.40 (1), p.22

2010

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Docking of a Specialized PIP Box onto Chromatin-Bound PCNA Creates a Degron for the Ubiquitin Ligase CRL4Cdt2

Molecular cell, 2009-07, Vol.35 (1), p.93-104

2009

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Direct Role for Proliferating Cell Nuclear Antigen in Substrate Recognition by the E3 Ubiquitin Ligase CRL4Cdt2

The Journal of biological chemistry, 2012-03, Vol.287 (14), p.11410-11421

2012

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Thymine DNA Glycosylase Is a CRL4Cdt2 Substrate

The Journal of biological chemistry, 2014-08, Vol.289 (33), p.23043-23055

2014

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Immunomodulatory agents lenalidomide and pomalidomide co‐stimulate T cells by inducing degradation of T cell repressors Ikaros and Aiolos via modulation of the E3 ubiquitin ligase complex CRL4CRBN

British journal of haematology, 2014-03, Vol.164 (6), p.811-821

2014

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Regulation of Late G1/S Phase Transition and APCCdh1 by Reactive Oxygen Species

Molecular and Cellular Biology, 2006-06, Vol.26 (12), p.4701-4711

2006

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Cellular effects of leishmanial tubulin inhibitors on L. donovani

Molecular and biochemical parasitology, 2000-10, Vol.110 (2), p.223-236

2000

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CC-92480, a Novel Cereblon E3 Ligase Modulator, Is Synergistic with Dexamethasone, Bortezomib, and Daratumumab in Multiple Myeloma

Blood, 2019-11, Vol.134 (Supplement_1), p.1815-1815

2019

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CC-92480 Is a Novel Cereblon E3 Ligase Modulator with Enhanced Tumoricidal and Immunomodulatory Activity Against Sensitive and Resistant Multiple Myeloma Cells

Blood, 2019-11, Vol.134 (Supplement_1), p.1812-1812

2019

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Mechanism of CRL4 Cdt2 , a PCNA-dependent E3 ubiquitin ligase

Genes & development, 2011-08, Vol.25 (15), p.1568-1582

2011

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Abstract 6047: Discovery and characterization of PVTX-321, an estrogen receptor heterobifunctional degrader

Cancer research (Chicago, Ill.), 2024-03, Vol.84 (6_Supplement), p.6047-6047

2024

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IMiDs® Immunomodulatory Agents Regulate Interferon-Stimulated Genes through Cereblon-Mediated Aiolos Destruction in Multiple Myeloma (MM) Cells: Identification of a Novel Mechanism of Action and Pathway for Resistance

Blood, 2014-12, Vol.124 (21), p.3432-3432

2014

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Degradation of Aiolos and Ikaros Followed By Downregulation of c-Myc and then IRF4 Leads to Programmed Cell Death in Myeloma Cells Sensitive to IMiDs® Immunomodulatory Compounds

Blood, 2014-12, Vol.124 (21), p.4700-4700

2014

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CC-122 Has Potent Anti-Lymphoma Activity through Destruction of the Aiolos and Ikaros Transcription Factors and Induction of Interferon Response Pathways

Blood, 2014-12, Vol.124 (21), p.3035-3035

2014

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Ribonucleotide reductase activity is regulated by proliferating cell nuclear antigen (PCNA)

Current biology, 2012-03, Vol.22 (8), p.720-726

2012

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Immunomodulatory agents lenalidomide and pomalidomide co‐stimulate T cells by inducing degradation of T cell repressors I karos and A iolos via modulation of the E 3 ubiquitin ligase complex CRL 4 CRBN

British journal of haematology, 2014-03, Vol.164 (6), p.811-821

2014

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Immunomodulatory agents lenalidomide and pomalidomide co-stimulate T cells by inducing degradation of T cell repressors Ikaros and Aiolos via modulation of the E3 ubiquitin ligase complex CRL4 CRBN

British journal of haematology, 2014, Vol.164 (6), p.811-821

2014

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Single Molecule Studies of Eukaryotic Replisomes in Xenopus Egg Extracts

Biophysical journal, 2010-01, Vol.98 (3), p.437a-437a

2010

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Discovery of CRBN E3 Ligase Modulator CC-92480 for the Treatment of Relapsed and Refractory Multiple Myeloma

A Genome-wide Screen Identifies p97 as an Essential Regulator of DNA Damage-Dependent CDT1 Destruction

CC-122, a pleiotropic pathway modifier, mimics an interferon response and has antitumor activity in DLBCL

Mechanism of CRL4(Cdt2), a PCNA-dependent E3 ubiquitin ligase

Ribonucleotide Reductase Activity Is Coupled to DNA Synthesis via Proliferating Cell Nuclear Antigen

Immunomodulatory agents lenalidomide and pomalidomide co-stimulate T cells by inducing degradation of T cell repressors Ikaros and Aiolos via modulation of the E3 ubiquitin ligase complex CRL4(CRBN.)

Mechanism of CRL4Cdt2, a PCNA-dependent E3 ubiquitin ligase

CRL4(Cdt2)-mediated destruction of the histone methyltransferase Set8 prevents premature chromatin compaction in S phase

Docking of a Specialized PIP Box onto Chromatin-Bound PCNA Creates a Degron for the Ubiquitin Ligase CRL4Cdt2

Direct Role for Proliferating Cell Nuclear Antigen in Substrate Recognition by the E3 Ubiquitin Ligase CRL4Cdt2

Thymine DNA Glycosylase Is a CRL4Cdt2 Substrate

Immunomodulatory agents lenalidomide and pomalidomide co‐stimulate T cells by inducing degradation of T cell repressors Ikaros and Aiolos via modulation of the E3 ubiquitin ligase complex CRL4CRBN

Regulation of Late G1/S Phase Transition and APCCdh1 by Reactive Oxygen Species

Cellular effects of leishmanial tubulin inhibitors on L. donovani

CC-92480, a Novel Cereblon E3 Ligase Modulator, Is Synergistic with Dexamethasone, Bortezomib, and Daratumumab in Multiple Myeloma

CC-92480 Is a Novel Cereblon E3 Ligase Modulator with Enhanced Tumoricidal and Immunomodulatory Activity Against Sensitive and Resistant Multiple Myeloma Cells

Mechanism of CRL4 Cdt2 , a PCNA-dependent E3 ubiquitin ligase

Abstract 6047: Discovery and characterization of PVTX-321, an estrogen receptor heterobifunctional degrader

IMiDs® Immunomodulatory Agents Regulate Interferon-Stimulated Genes through Cereblon-Mediated Aiolos Destruction in Multiple Myeloma (MM) Cells: Identification of a Novel Mechanism of Action and Pathway for Resistance

Degradation of Aiolos and Ikaros Followed By Downregulation of c-Myc and then IRF4 Leads to Programmed Cell Death in Myeloma Cells Sensitive to IMiDs® Immunomodulatory Compounds

CC-122 Has Potent Anti-Lymphoma Activity through Destruction of the Aiolos and Ikaros Transcription Factors and Induction of Interferon Response Pathways

Ribonucleotide reductase activity is regulated by proliferating cell nuclear antigen (PCNA)

Immunomodulatory agents lenalidomide and pomalidomide co‐stimulate T cells by inducing degradation of T cell repressors I karos and A iolos via modulation of the E 3 ubiquitin ligase complex CRL 4 CRBN

Immunomodulatory agents lenalidomide and pomalidomide co-stimulate T cells by inducing degradation of T cell repressors Ikaros and Aiolos via modulation of the E3 ubiquitin ligase complex CRL4 CRBN

Single Molecule Studies of Eukaryotic Replisomes in Xenopus Egg Extracts

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