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Dissecting fibrosis: therapeutic insights from the small-molecule toolbox

Nature reviews. Drug discovery, 2015-10, Vol.14 (10), p.693-720

2015

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An αv‐RGD Integrin Inhibitor Toolbox: Drug Discovery Insight, Challenges and Opportunities

Angewandte Chemie International Edition, 2018-03, Vol.57 (13), p.3298-3321

International ed. in English, 2018

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How Diverse Is Medicinal Chemistry? Insights into Race, Ethnicity, Origin, Gender, and Geography

Journal of medicinal chemistry, 2022-01, Vol.65 (1), p.37-57

2022

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Writing Your Next Medicinal Chemistry Article: Journal Bibliometrics and Guiding Principles for Industrial Authors

Journal of medicinal chemistry, 2020-12, Vol.63 (23), p.14336-14356

2020

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Sprinkling the pixie dust: reflections on innovation and innovators in medicinal chemistry and drug discovery

Drug discovery today, 2020-03, Vol.25 (3), p.599-609

2020

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Synthesis of Rhazinicine by a Metal-Catalyzed CH Bond Functionalization Strategy

Angewandte Chemie International Edition, 2008-04, Vol.47 (16), p.3004-3007

2008

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Synthetic approaches to N- and 4-substituted 1,4-dihydro-3(2H)-isoquinolinone derivatives

Tetrahedron, 2021-11, Vol.100, p.132455, Article 132455

2021

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Core Modifications of GSK3335103 toward Orally Bioavailable α v β 6 Inhibitors with Improved Synthetic Tractability

Journal of medicinal chemistry, 2024-10

2024

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Mild Aerobic Oxidative Palladium (II) Catalyzed C−H Bond Functionalization: Regioselective and Switchable C−H Alkenylation and Annulation of Pyrroles

Journal of the American Chemical Society, 2006-03, Vol.128 (8), p.2528-2529

2006

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Discovery and Development of Highly Potent and Orally Bioavailable Nonpeptidic α v β 6 Integrin Inhibitors

Journal of medicinal chemistry, 2024-10, Vol.67 (19), p.17497-17519

2024

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Discovery and Development of Highly Potent and Orally Bioavailable Nonpeptidic αvβ6 Integrin Inhibitors

Journal of medicinal chemistry, 2024-10, Vol.67 (19), p.17497-17519

2024

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The Design of Potent, Selective and Drug‐Like RGD αvβ1 Small‐Molecule Inhibitors Derived from non‐RGD α4β1 Antagonists

ChemMedChem, 2019-07, Vol.14 (14), p.1315-1320

2019

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Pharmacological characterisation of GSK3335103, an oral αvβ6 integrin small molecule RGD-mimetic inhibitor for the treatment of fibrotic disease

European journal of pharmacology, 2021-12, Vol.913, p.174618, Article 174618

2021

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Ein Instrumentarium von αv‐RGD‐Integrin‐Inhibitoren: Wirkstoffsuche, Herausforderungen und Möglichkeiten

Angewandte Chemie, 2018-03, Vol.130 (13), p.3354-3379

2018

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Determination of the absolute configuration of (+)- and (−)-N-CBZ-3-fluoropyrrolidine-3-methanol using vibrational circular dichroism and confirmation of stereochemistry by conversion to (R)-tert-butyl 3-fluoro-3-(((R)-1-phenylethyl)carbamoyl)pyrrolidine-1-carboxylate

Tetrahedron: asymmetry, 2016-12, Vol.27 (24), p.1222-1230

2016

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2,5-Diketopiperazines as Potent, Selective, and Orally Bioavailable Oxytocin Antagonists. 3. Synthesis, Pharmacokinetics, and in Vivo Potency

Journal of medicinal chemistry, 2006-07, Vol.49 (14), p.4159-4170

2006

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2,5-Diketopiperazines as potent and selective oxytocin antagonists 1: identification, stereochemistry and initial SAR

Bioorganic & medicinal chemistry letters, 2005-05, Vol.15 (10), p.2579-2582

2005

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Formal synthesis of roseophilin

Chemical communications (Cambridge, England), 1999-08 (16), p.1455-1456

1999

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Core Modifications of GSK3335103 toward Orally Bioavailable αvβ6 Inhibitors with Improved Synthetic Tractability

Journal of medicinal chemistry, 2024-10

2024

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Latonduine Analogs Restore F508del-Cystic Fibrosis Transmembrane Conductance Regulator Trafficking through the Modulation of Poly-ADP Ribose Polymerase 3 and Poly-ADP Ribose Polymerase 16 Activity

Molecular pharmacology, 2016-08, Vol.90 (2), p.65-79

2016

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Synthesis of Rhazinicine by a Metal-Catalyzed CH Bond Functionalization Strategy

Angewandte Chemie, 2008-04, Vol.120 (16), p.3046-3049

2008

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Preparation of the tricyclic ketopyrrole core of roseophilin by radical macrocyclisation and Paal–Knorr condensation

Perkin 1 : an international journal of organic and bio-organic chemistry, 2000-01 (20), p.3389-3396

2000

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Ein Instrumentarium von αv‐RGD‐Integrin‐Inhibitoren: Wirkstoffsuche, Herausforderungen und Möglichkeiten

Angewandte Chemie, 2018-03, Vol.130 (13), p.3354-3379

2018

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Synthesis of Rhazinicine by a Metal‐Catalyzed CH Bond Functionalization Strategy

Angewandte Chemie, 2008-04, Vol.120 (16), p.3046-3049

2008

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Educational Change— Promises, Pitfalls, and Promises

NASSP bulletin, 1979-03, Vol.63 (425), p.1-8

Hatley, Richard V.

1979

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Dissecting fibrosis: therapeutic insights from the small-molecule toolbox

An αv‐RGD Integrin Inhibitor Toolbox: Drug Discovery Insight, Challenges and Opportunities

How Diverse Is Medicinal Chemistry? Insights into Race, Ethnicity, Origin, Gender, and Geography

Writing Your Next Medicinal Chemistry Article: Journal Bibliometrics and Guiding Principles for Industrial Authors

Sprinkling the pixie dust: reflections on innovation and innovators in medicinal chemistry and drug discovery

Synthesis of Rhazinicine by a Metal-Catalyzed CH Bond Functionalization Strategy

Synthetic approaches to N- and 4-substituted 1,4-dihydro-3(2H)-isoquinolinone derivatives

Core Modifications of GSK3335103 toward Orally Bioavailable α v β 6 Inhibitors with Improved Synthetic Tractability

Mild Aerobic Oxidative Palladium (II) Catalyzed C−H Bond Functionalization: Regioselective and Switchable C−H Alkenylation and Annulation of Pyrroles

Discovery and Development of Highly Potent and Orally Bioavailable Nonpeptidic α v β 6 Integrin Inhibitors

Discovery and Development of Highly Potent and Orally Bioavailable Nonpeptidic αvβ6 Integrin Inhibitors

The Design of Potent, Selective and Drug‐Like RGD αvβ1 Small‐Molecule Inhibitors Derived from non‐RGD α4β1 Antagonists

Pharmacological characterisation of GSK3335103, an oral αvβ6 integrin small molecule RGD-mimetic inhibitor for the treatment of fibrotic disease

Ein Instrumentarium von αv‐RGD‐Integrin‐Inhibitoren: Wirkstoffsuche, Herausforderungen und Möglichkeiten

Determination of the absolute configuration of (+)- and (−)-N-CBZ-3-fluoropyrrolidine-3-methanol using vibrational circular dichroism and confirmation of stereochemistry by conversion to (R)-tert-butyl 3-fluoro-3-(((R)-1-phenylethyl)carbamoyl)pyrrolidine-1-carboxylate

2,5-Diketopiperazines as Potent, Selective, and Orally Bioavailable Oxytocin Antagonists. 3. Synthesis, Pharmacokinetics, and in Vivo Potency

2,5-Diketopiperazines as potent and selective oxytocin antagonists 1: identification, stereochemistry and initial SAR

Formal synthesis of roseophilin

Core Modifications of GSK3335103 toward Orally Bioavailable αvβ6 Inhibitors with Improved Synthetic Tractability

Latonduine Analogs Restore F508del-Cystic Fibrosis Transmembrane Conductance Regulator Trafficking through the Modulation of Poly-ADP Ribose Polymerase 3 and Poly-ADP Ribose Polymerase 16 Activity

Synthesis of Rhazinicine by a Metal-Catalyzed CH Bond Functionalization Strategy

Preparation of the tricyclic ketopyrrole core of roseophilin by radical macrocyclisation and Paal–Knorr condensation

Ein Instrumentarium von αv‐RGD‐Integrin‐Inhibitoren: Wirkstoffsuche, Herausforderungen und Möglichkeiten

Synthesis of Rhazinicine by a Metal‐Catalyzed CH Bond Functionalization Strategy

Educational Change— Promises, Pitfalls, and Promises

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