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A mechanistic framework for a priori pharmacokinetic predictions of orally inhaled drugs

PLoS computational biology, 2020-12, Vol.16 (12), p.e1008466

2020

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Physiology-based toxicokinetic modelling of aluminium in rat and man

Archives of toxicology, 2021-09, Vol.95 (9), p.2977-3000

2021

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Role of renal function in risk assessment of target non-attainment after standard dosing of meropenem in critically ill patients: a prospective observational study

Critical care (London, England), 2017-10, Vol.21 (1), p.263-263, Article 263

2017

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Reinforcement learning and Bayesian data assimilation for model‐informed precision dosing in oncology

CPT: pharmacometrics and systems pharmacology, 2021-03, Vol.10 (3), p.241-254

2021

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Nonparametric goodness‐of‐fit testing for parametric covariate models in pharmacometric analyses

CPT: pharmacometrics and systems pharmacology, 2021-06, Vol.10 (6), p.564-576

2021

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Bayesian Data Assimilation to Support Informed Decision Making in Individualized Chemotherapy

CPT: pharmacometrics and systems pharmacology, 2020-03, Vol.9 (3), p.153-164

2020

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A continued learning approach for model‐informed precision dosing: Updating models in clinical practice

CPT: pharmacometrics and systems pharmacology, 2022-02, Vol.11 (2), p.185-198

2022

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The circadian rhythm of corticosteroid‐binding globulin has little impact on cortisol exposure after hydrocortisone dosing

Clinical endocrinology (Oxford), 2019-07, Vol.91 (1), p.33-40

2019

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C-Reactive Protein as an Early Predictor of Efficacy in Advanced Non-Small-Cell Lung Cancer Patients: A Tumor Dynamics-Biomarker Modeling Framework

Cancers, 2023-11, Vol.15 (22), p.5429

2023

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A prognostic baseline blood biomarker and tumor growth kinetics integrated model in paclitaxel/platinum treated advanced non-small cell lung cancer patients

CPT: pharmacometrics and systems pharmacology, 2023-11, Vol.12 (11), p.1714-1725

2023

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Study of metastatic kinetics in metastatic melanoma treated with B-RAF inhibitors: Introducing mathematical modelling of kinetics into the therapeutic decision

PloS one, 2017-05, Vol.12 (5), p.e0176080-e0176080

2017

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Parameter non-identifiability of the Gyllenberg–Webb ODE model

Journal of mathematical biology, 2014, Vol.68 (1-2), p.41-55

Hartung, Niklas

2014

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Mathematical modeling of tumor growth and metastatic spreading: validation in tumor-bearing mice

Cancer research (Chicago, Ill.), 2014-11, Vol.74 (22), p.6397-6407

2014

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Pharmacokinetic/Pharmacodynamic Evaluation of Hydrocortisone Therapy in Pediatric Patients with Congenital Adrenal Hyperplasia

The journal of clinical endocrinology and metabolism, 2020-04, Vol.105 (4), p.e1729-e1740

2020

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Time-to-Event Analysis of Paclitaxel-Associated Peripheral Neuropathy in Advanced Non-Small-Cell Lung Cancer Highlighting Key Influential Treatment/Patient Factors

The Journal of pharmacology and experimental therapeutics, 2020-12, Vol.375 (3), p.430

2020

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Paracrine and autocrine regulation of gene expression by Wnt-inhibitor Dickkopf in wild-type and mutant hepatocytes

BMC systems biology, 2017-10, Vol.11 (1), p.98-98, Article 98

2017

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Predicting Cortisol Exposure from Paediatric Hydrocortisone Formulation Using a Semi-Mechanistic Pharmacokinetic Model Established in Healthy Adults

Clinical pharmacokinetics, 2018-04, Vol.57 (4), p.515-527

2018

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An Efficient Implementation of a 3D CeVeFE DDFV Scheme on Cartesian Grids and an Application in Image Processing

Finite Volumes for Complex Applications VII-Elliptic, Parabolic and Hyperbolic Problems, p.637-645

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Abstract 402: A new mathematical model for describing metastatic spreading: Validation in tumor-bearing mice, confrontation with clinical data and in silico simulations to optimize treatment modalities

Cancer research (Chicago, Ill.), 2013-04, Vol.73 (8_Supplement), p.402-402

2013

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Model Description Language (MDL): A Standard for Modeling and Simulation

CPT: pharmacometrics and systems pharmacology, 2017-10, Vol.6 (10), p.647-650

2017

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Early alpha-lipoic acid therapy protects from degeneration of the inner retinal layers and vision loss in an experimental autoimmune encephalomyelitis-optic neuritis model

Journal of neuroinflammation, 2018-03, Vol.15 (1), p.71-71, Article 71

2018

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Measuring the photoelectron emission delay in the molecular frame

Nature communications, 2021-11, Vol.12 (1), p.6657-6657, Article 6657

2021

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Eculizumab versus rituximab in generalised myasthenia gravis

Journal of neurology, neurosurgery and psychiatry, 2022-05, Vol.93 (5), p.548

2022

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A Matched-pair Analysis Comparing Systematic Prostate Biopsy by Conventional Transrectal Ultrasound-guidance Versus Software-based Predefined 3D-Guidance

Urology (Ridgewood, N.J.), 2023-07, Vol.177, p.128-133

2023

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A mechanistic framework for a priori pharmacokinetic predictions of orally inhaled drugs

Physiology-based toxicokinetic modelling of aluminium in rat and man

Role of renal function in risk assessment of target non-attainment after standard dosing of meropenem in critically ill patients: a prospective observational study

Reinforcement learning and Bayesian data assimilation for model‐informed precision dosing in oncology

Nonparametric goodness‐of‐fit testing for parametric covariate models in pharmacometric analyses

Bayesian Data Assimilation to Support Informed Decision Making in Individualized Chemotherapy

A continued learning approach for model‐informed precision dosing: Updating models in clinical practice

The circadian rhythm of corticosteroid‐binding globulin has little impact on cortisol exposure after hydrocortisone dosing

C-Reactive Protein as an Early Predictor of Efficacy in Advanced Non-Small-Cell Lung Cancer Patients: A Tumor Dynamics-Biomarker Modeling Framework

A prognostic baseline blood biomarker and tumor growth kinetics integrated model in paclitaxel/platinum treated advanced non-small cell lung cancer patients

Study of metastatic kinetics in metastatic melanoma treated with B-RAF inhibitors: Introducing mathematical modelling of kinetics into the therapeutic decision

Parameter non-identifiability of the Gyllenberg–Webb ODE model

Mathematical modeling of tumor growth and metastatic spreading: validation in tumor-bearing mice

Pharmacokinetic/Pharmacodynamic Evaluation of Hydrocortisone Therapy in Pediatric Patients with Congenital Adrenal Hyperplasia

Time-to-Event Analysis of Paclitaxel-Associated Peripheral Neuropathy in Advanced Non-Small-Cell Lung Cancer Highlighting Key Influential Treatment/Patient Factors

Paracrine and autocrine regulation of gene expression by Wnt-inhibitor Dickkopf in wild-type and mutant hepatocytes

Predicting Cortisol Exposure from Paediatric Hydrocortisone Formulation Using a Semi-Mechanistic Pharmacokinetic Model Established in Healthy Adults

An Efficient Implementation of a 3D CeVeFE DDFV Scheme on Cartesian Grids and an Application in Image Processing

Abstract 402: A new mathematical model for describing metastatic spreading: Validation in tumor-bearing mice, confrontation with clinical data and in silico simulations to optimize treatment modalities

Model Description Language (MDL): A Standard for Modeling and Simulation

Early alpha-lipoic acid therapy protects from degeneration of the inner retinal layers and vision loss in an experimental autoimmune encephalomyelitis-optic neuritis model

Measuring the photoelectron emission delay in the molecular frame

Eculizumab versus rituximab in generalised myasthenia gravis

A Matched-pair Analysis Comparing Systematic Prostate Biopsy by Conventional Transrectal Ultrasound-guidance Versus Software-based Predefined 3D-Guidance

Vaccine-based clinical protection against SARS-CoV-2 infection and the humoral immune response: A 1-year follow-up study of patients with multiple sclerosis receiving ocrelizumab

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