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Molecular mechanism and clinical impact of APOBEC3B-catalyzed mutagenesis in breast cancer

Breast cancer research : BCR, 2015-01, Vol.17 (1), p.8-8, Article 8

Harris, Reuben S

2015

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APOBECs and virus restriction

Virology (New York, N.Y.), 2015-05, Vol.479, p.131-145

2015

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APOBEC Enzymes: Mutagenic Fuel for Cancer Evolution and Heterogeneity

Cancer discovery, 2015-07, Vol.5 (7), p.704-712

2015

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Evidence for APOBEC3B mutagenesis in multiple human cancers

Nature genetics, 2013-09, Vol.45 (9), p.977-983

2013

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The Restriction Factors of Human Immunodeficiency Virus

The Journal of biological chemistry, 2012-11, Vol.287 (49), p.40875-40883

2012

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The APOBEC3 family of retroelement restriction factors

Current topics in microbiology and immunology, 2013-01, Vol.371, p.1

2013

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APOBEC Enzymes as Targets for Virus and Cancer Therapy

Cell chemical biology, 2018-01, Vol.25 (1), p.36-49

2018

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Functional Upregulation of the DNA Cytosine Deaminase APOBEC3B by Polyomaviruses

Journal of virology, 2016-07, Vol.90 (14), p.6379-6386

2016

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HIV-1 adaptation studies reveal a novel Env-mediated homeostasis mechanism for evading lethal hypermutation by APOBEC3G

PLoS pathogens, 2018-04, Vol.14 (4), p.e1007010

2018

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Cellular Assays for Dynamic Quantification of Deubiquitinase Activity and Inhibition

Journal of molecular biology, 2023-12, Vol.435 (23), p.168316-168316, Article 168316

2023

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Deaminase deluge yields new opportunities for biotechnology and genome engineering

Molecular cell, 2024-03, Vol.84 (5), p.816-818

2024

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Structural basis for targeted DNA cytosine deamination and mutagenesis by APOBEC3A and APOBEC3B

Nature structural & molecular biology, 2017-02, Vol.24 (2), p.131-139

2017

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A role for gorilla APOBEC3G in shaping lentivirus evolution including transmission to humans

PLoS pathogens, 2020-09, Vol.16 (9), p.e1008812-e1008812

2020

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APOBEC3B is an enzymatic source of mutation in breast cancer

Nature (London), 2013-02, Vol.494 (7437), p.366-370

2013

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Crystal Structure of the DNA Deaminase APOBEC3B Catalytic Domain

The Journal of biological chemistry, 2015-11, Vol.290 (47), p.28120-28130

2015

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APOBEC3 proteins mediate the clearance of foreign DNA from human cells

Nature structural & molecular biology, 2010-02, Vol.17 (2), p.222-229

2010

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Human and Rhesus APOBEC3D, APOBEC3F, APOBEC3G, and APOBEC3H Demonstrate a Conserved Capacity To Restrict Vif-Deficient HIV-1

Journal of Virology, 2011-11, Vol.85 (21), p.11220-11234

2011

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APOBEC3A catalyzes mutation and drives carcinogenesis in vivo

The Journal of experimental medicine, 2020-12, Vol.217 (12)

2020

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Studies on antiviral resistant SARS-CoV-2 Mpro mutants

Biophysical journal, 2023-02, Vol.122 (3), p.39a-39a

2023

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Endogenous origins of HIV-1 G-to-A hypermutation and restriction in the nonpermissive T cell line CEM2n

PLoS pathogens, 2012-07, Vol.8 (7), p.e1002800

2012

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Mapping clustered mutations in cancer reveals APOBEC3 mutagenesis of ecDNA

Nature (London), 2022-02, Vol.602 (7897), p.510-517

2022

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Evolutionary Paradigms from Ancient and Ongoing Conflicts between the Lentiviral Vif Protein and Mammalian APOBEC3 Enzymes

PLoS pathogens, 2016-12, Vol.12 (12), p.e1005958-e1005958

2016

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Dual Functionality of HIV-1 Vif in APOBEC3 Counteraction and Cell Cycle Arrest

Frontiers in microbiology, 2021-01, Vol.11, p.622012-622012

2021

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The DNA cytosine deaminase APOBEC3H haplotype I likely contributes to breast and lung cancer mutagenesis

Nature communications, 2016-09, Vol.7 (1), p.12918-13, Article 12918

2016

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Natural polymorphisms in human APOBEC3H and HIV-1 Vif combine in primary T lymphocytes to affect viral G-to-A mutation levels and infectivity

PLoS genetics, 2014-11, Vol.10 (11), p.e1004761-e1004761

2014

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Molecular mechanism and clinical impact of APOBEC3B-catalyzed mutagenesis in breast cancer

APOBECs and virus restriction

APOBEC Enzymes: Mutagenic Fuel for Cancer Evolution and Heterogeneity

Evidence for APOBEC3B mutagenesis in multiple human cancers

The Restriction Factors of Human Immunodeficiency Virus

The APOBEC3 family of retroelement restriction factors

APOBEC Enzymes as Targets for Virus and Cancer Therapy

Functional Upregulation of the DNA Cytosine Deaminase APOBEC3B by Polyomaviruses

HIV-1 adaptation studies reveal a novel Env-mediated homeostasis mechanism for evading lethal hypermutation by APOBEC3G

Cellular Assays for Dynamic Quantification of Deubiquitinase Activity and Inhibition

Deaminase deluge yields new opportunities for biotechnology and genome engineering

Structural basis for targeted DNA cytosine deamination and mutagenesis by APOBEC3A and APOBEC3B

A role for gorilla APOBEC3G in shaping lentivirus evolution including transmission to humans

APOBEC3B is an enzymatic source of mutation in breast cancer

Crystal Structure of the DNA Deaminase APOBEC3B Catalytic Domain

APOBEC3 proteins mediate the clearance of foreign DNA from human cells

Human and Rhesus APOBEC3D, APOBEC3F, APOBEC3G, and APOBEC3H Demonstrate a Conserved Capacity To Restrict Vif-Deficient HIV-1

APOBEC3A catalyzes mutation and drives carcinogenesis in vivo

Studies on antiviral resistant SARS-CoV-2 Mpro mutants

Endogenous origins of HIV-1 G-to-A hypermutation and restriction in the nonpermissive T cell line CEM2n

Mapping clustered mutations in cancer reveals APOBEC3 mutagenesis of ecDNA

Evolutionary Paradigms from Ancient and Ongoing Conflicts between the Lentiviral Vif Protein and Mammalian APOBEC3 Enzymes

Dual Functionality of HIV-1 Vif in APOBEC3 Counteraction and Cell Cycle Arrest

The DNA cytosine deaminase APOBEC3H haplotype I likely contributes to breast and lung cancer mutagenesis

Natural polymorphisms in human APOBEC3H and HIV-1 Vif combine in primary T lymphocytes to affect viral G-to-A mutation levels and infectivity

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